The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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First-in-human, phase I, dose-escalation study of selective PI3Kα isoform inhibitor MLN1117 in patients (pts) with advanced solid malignancies.
 
Dejan Juric
Consulting or Advisory Role - BIND Therapeutics; Eisai; Novartis
 
Johann Sebastian De Bono
Honoraria - Astellas Pharma; AstraZeneca; Genentech/Roche; Pfizer; Sanofi
Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Genentech/Roche; Sanofi
Research Funding - Arno Therapeutics (Inst); AstraZeneca (Inst); Genentech (Inst); Sanofi (Inst); Tokai Pharmaceuticals (Inst)
 
Patricia LoRusso
Consulting or Advisory Role - Astellas Pharma; Astex Pharmaceuticals; Genentech; Novartis
Speakers' Bureau - Genentech
Research Funding - Genentech (Inst); Immunogen (Inst); Merrimack (Inst); Novartis (Inst); Taiho Pharmaceutical (Inst); Tensha Therapeutics (Inst)
 
John J. Nemunaitis
Stock and Other Ownership Interests - Gradalis
Patents, Royalties, Other Intellectual Property - Gradalis
 
Elisabeth I. Heath
Honoraria - Bayer; Dendreon
Research Funding - Agensys (Inst); Dendreon (Inst); Genentech/Roche (Inst); Millennium (Inst); Seagen (Inst); Tokai Pharmaceuticals (Inst)
 
Eunice Lee Kwak
Research Funding - Millennium
Travel, Accommodations, Expenses - Amgen; Pfizer
 
Teresa Macarulla
No Relationships to Disclose
 
Elena Geuna
No Relationships to Disclose
 
Maria Jose de Miguel Luken
No Relationships to Disclose
 
Chirag Patel
Employment - Millennium
Stock and Other Ownership Interests - Millennium
Research Funding - Millennium
 
Keisuke Kuida
Employment - Millennium
Stock and Other Ownership Interests - Vertex
 
Serap Sankoh
Employment - Millennium
Stock and Other Ownership Interests - Vertex
 
Fabian Zohren
Employment - Millennium
Stock and Other Ownership Interests - Millennium
Travel, Accommodations, Expenses - Millennium
 
Yaping Shou
Employment - Millennium
Stock and Other Ownership Interests - Millennium
Patents, Royalties, Other Intellectual Property - GlaxoSmithKline; Millennium; Novartis
Travel, Accommodations, Expenses - Millennium
 
Josep Tabernero
Consulting or Advisory Role - Amgen; Celgene; Chugai Pharma; ImClone Systems; Lilly; Merck KGaA; Millennium; Novartis; Roche/Genentech; Sanofi; Symphony Evolution; Taiho Pharmaceutical