The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Efficacy results of a phase 1b study of ont-380, a CNS-penetrant TKI, in combination with T-DM1 in HER2+ metastatic breast cancer (MBC), including patients (pts) with brain metastases.
 
Virginia F. Borges
No Relationships to Disclose
 
Cristiano Ferrario
Honoraria - Amgen; Bayer
Consulting or Advisory Role - Novartis; Roche; Sanofi
Research Funding - Abbvie; Alethia Biotherapeutics; Astellas Pharma; AstraZeneca; Celldex; Lilly; Merck; Novartis; Oncothyreon; Roche; Sanofi
Expert Testimony - Astellas Pharma
Travel, Accommodations, Expenses - Bayer; Roche
 
Nathalie Aucoin
No Relationships to Disclose
 
Carla Isadora Falkson
No Relationships to Disclose
 
Qamar J. Khan
Consulting or Advisory Role - NanoString Technologies; Roche/Genentech
Research Funding - Celgene; Novartis
 
Ian E. Krop
Employment - Vertex (I)
Leadership - Vertex (I)
Stock and Other Ownership Interests - Vertex (I)
Consulting or Advisory Role - Amgen
Research Funding - Genentech
Travel, Accommodations, Expenses - Bayer
 
Stephen Welch
Honoraria - Amgen; Celgene; Roche; Sanofi
Consulting or Advisory Role - Amgen; Roche
Research Funding - Amgen (Inst); Sanofi (Inst)
Travel, Accommodations, Expenses - Roche
 
Philippe L. Bedard
Consulting or Advisory Role - Genentech/Roche (Inst); Pfizer (Inst); Sanofi (Inst)
Research Funding - AstraZeneca (Inst); Bristol-Myers Squibb (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); Novartis (Inst); Oncothyreon (Inst); PTC Therapeutics (Inst); Sanofi (Inst); SERVIER (Inst); SignalChem (Inst)
 
Alison Katherine Conlin
Consulting or Advisory Role - Celgene
 
Jorge Chaves
No Relationships to Disclose
 
Luke N. Walker
Employment - Oncothyreon
Stock and Other Ownership Interests - Oncothyreon
 
Erika Paige Hamilton
No Relationships to Disclose