The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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A first in human phase I study of AZD8186, a potent and selective inhibitor of PI3K in patients with advanced solid tumours as monotherapy and in combination with the dual mTORC1/2 inhibitor vistusertib (AZD2014) or abiraterone acetate.
 
Aaron Richard Hansen
No Relationships to Disclose
 
Geoffrey Shapiro
Consulting or Advisory Role - G1 Therapeutics; Lilly; Pfizer; Vertex
Research Funding - Aileron Therapeutics (Inst); AstraZeneca (Inst); Bayer (Inst); Cellceutix (Inst); Covidien (Inst); Cyclacel (Inst); Genentech (Inst); GlaxoSmithKline (Inst); Immune Design (Inst); Lilly; Lilly (Inst); Millennium (Inst); Mirati Therapeutics (Inst); Novartis (Inst); Pfizer (Inst); PharmaMar (Inst); PTC Therapeutics (Inst); Puma Biotechnology (Inst); Sanofi (Inst); Tensha Therapeutics (Inst); Vertex (Inst)
 
Khanh T Do
No Relationships to Disclose
 
Rajiv Kumar
No Relationships to Disclose
 
Juan Martin-Liberal
No Relationships to Disclose
 
Celestia S. Higano
Employment - CTI (I)
Leadership - CTI (I)
Stock and Other Ownership Interests - CTI (I)
Consulting or Advisory Role - Asana Biosciences; Astellas Pharma; Bayer; Blue Earth Diagnostics; Churchill Pharmaceuticals; Clovis Oncology; Dendreon; Emergent BioSolutions; Endocyte; Ferring; Medivation; MorphoSys; Orion; Parexel
Research Funding - Algeta/Bayer (Inst); Aragon Pharmaceuticals (Inst); AstraZeneca (Inst); Bayer (Inst); Dendreon (Inst); Emergent BioSolutions (Inst); Genentech (Inst); Medivation (Inst); Pfizer (Inst); Sanofi (Inst)
Travel, Accommodations, Expenses - Asana Biosciences; Astellas Pharma; Astellas Pharma; Bayer; Bayer; Blue Earth Diagnostics; Churchill Pharmaceuticals; Clovis Oncology; Dendreon; Emergent BioSolutions; Emergent BioSolutions; Endocyte; Ferring
 
Kari Braun Wisinski
Research Funding - AstraZeneca (Inst); Daiichi Sankyo (Inst); Eisai; Lilly (Inst); Novartis (Inst)
 
Emma Jane Dean
Consulting or Advisory Role - Aptus Clinical (Inst); Theradex Ltd
Travel, Accommodations, Expenses - AstraZeneca
 
Elisabeth I. Heath
Honoraria - Bayer; Dendreon; Sanofi
Consulting or Advisory Role - Agensys
Speakers' Bureau - Sanofi
Research Funding - Agensys (Inst); Celgene (Inst); Celldex (Inst); Dendreon (Inst); Genentech/Roche (Inst); Inovio Pharmaceuticals (Inst); Millennium (Inst); Seagen (Inst); Tokai Pharmaceuticals (Inst)
 
Dana E. Rathkopf
Consulting or Advisory Role - Janssen Oncology
Research Funding - AstraZeneca (Inst); Celgene (Inst); Ferring (Inst); Genentech/Roche (Inst); Janssen Oncology (Inst); Medivation (Inst); Millennium (Inst); Novartis (Inst); Taiho Pharmaceutical (Inst); Takeda (Inst); TRACON Pharma (Inst)
 
Mark David Linch
Consulting or Advisory Role - Janssen
Research Funding - Io Therapeutics (Inst)
Travel, Accommodations, Expenses - Bayer; Janssen
 
Simon T Barry
Employment - AstraZeneca
Stock and Other Ownership Interests - AstraZeneca
Patents, Royalties, Other Intellectual Property - AstraZeneca (Inst)
 
Wolfram Brugger
Employment - AstraZeneca
Stock and Other Ownership Interests - AstraZeneca
Honoraria - AstraZeneca; Bayer; Boehringer Ingelheim; Bristol-Myers Squibb; Lilly; Mundipharma; Novartis; Pfizer; Roche
Consulting or Advisory Role - AstraZeneca; Mundipharma; Novartis; Roche
Travel, Accommodations, Expenses - AstraZeneca; Boehringer Ingelheim; Celgene; Mundipharma; Roche
 
Elza De Bruin
Employment - AstraZeneca
 
Steve Colebrook
Employment - AstraZeneca
Stock and Other Ownership Interests - AstraZeneca
 
Teresa Klinowska
Employment - AstraZeneca
Stock and Other Ownership Interests - AstraZeneca
 
Patrick D Mitchell
Employment - AstraZeneca
Stock and Other Ownership Interests - AstraZeneca
 
Ganesh Moorthy
Employment - AstraZeneca
 
Johann S. De Bono
Honoraria - Astellas Pharma; AstraZeneca; Genentech/Roche; Pfizer; Sanofi
Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Genentech/Roche; Sanofi
Research Funding - AstraZeneca (Inst); Genentech (Inst); Sanofi (Inst)
Patents, Royalties, Other Intellectual Property - Abiraterone Rewards to Inventors (Inst); PARP inhibitors and DNA repair defects (Inst)
Travel, Accommodations, Expenses - Astellas Pharma; AstraZeneca; Genmab; GlaxoSmithKline; Orion; Qiagen; Sanofi; Taiho Pharmaceutical; Vertex
 
Lillian L. Siu
Leadership - Agios (I)
Consulting or Advisory Role - AstraZeneca/MedImmune; Boehringer Ingelheim; Celgene; Merck; Pfizer
Research Funding - Amgen; AstraZeneca; Bayer; Boehringer Ingelheim; Bristol-Myers Squibb; Genentech/Roche; GlaxoSmithKline; MedImmune; Merck; Novartis; Pfizer