The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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A phase I trial of selective PI3K inhibitor taselisib (tas) plus palbociclib (palb) with and without endocrine therapy incorporating pharmacodynamic (PD) studies in patients (pts) with advanced cancers.
 
Joline Si Jing Lim
No Relationships to Disclose
 
Uzma Saddia Asghar
No Relationships to Disclose
 
Nikolaos Diamantis
No Relationships to Disclose
 
Sarah Emily Ward
No Relationships to Disclose
 
Mona Parmar
No Relationships to Disclose
 
Beth Purchase
No Relationships to Disclose
 
Florence I. Raynaud
Consulting or Advisory Role - Agilent
Patents, Royalties, Other Intellectual Property - Inventor's award from ICR, London
Travel, Accommodations, Expenses - Biocrates
 
Karen E Swales
Research Funding - AstraZeneca (Inst); Boehringer Ingelheim (Inst); GlaxoSmithKline (Inst); Verastem (Inst); Vertex (Inst)
Patents, Royalties, Other Intellectual Property - Employees of The Institute of Cancer Research are subject to a Rewards to Inventors Scheme which may reward contributors to a programme that is subsequently licensed.
 
Sarah Hrebien
No Relationships to Disclose
 
Emma Hall
Research Funding - Accuray; AstraZeneca; Bayer; Cambridge Laboratories; Kyowa Hakko Kirin; Sanofi
 
Holly Tovey
Research Funding - AstraZeneca (Inst); Johnson & Johnson (Inst); Pfizer (Inst)
Patents, Royalties, Other Intellectual Property - Employees of the ICR are subject to a "Rewards to Inventors Scheme" which may reward contributors to a programme that is subsequently licensed.
 
Hannah Bye
No Relationships to Disclose
 
Paula Proszek
No Relationships to Disclose
 
Juanita Suzanne Lopez
No Relationships to Disclose
 
Alison Joanne Turner
No Relationships to Disclose
 
Johann S. De Bono
Honoraria - Astellas Pharma; AstraZeneca; Genentech/Roche; Pfizer; Sanofi
Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Genentech/Roche; Sanofi
Research Funding - AstraZeneca (Inst); Genentech (Inst); Sanofi (Inst)
Patents, Royalties, Other Intellectual Property - Abiraterone Rewards to Inventors (Inst); PARP inhibitors and DNA repair defects (Inst)
Travel, Accommodations, Expenses - Astellas Pharma; AstraZeneca; Genmab; GlaxoSmithKline; Orion; Qiagen; Sanofi; Taiho Pharmaceutical; Vertex
 
Udai Banerji
Employment - Institute of Cancer Research
Consulting or Advisory Role - Astex Pharmaceuticals; Novartis
Research Funding - AstraZeneca (Inst); Chugai Pharma (Inst); Onyx (Inst)
 
Timothy Anthony Yap
Consulting or Advisory Role - Bristol-Myers Squibb; Pfizer
Research Funding - AstraZeneca; Clearbridge Biomedics; Vertex
Patents, Royalties, Other Intellectual Property - Employee of The Institute of Cancer Research, which has a financial interest in the discovery and development of anticancer drugs (Inst)
Travel, Accommodations, Expenses - Bristol-Myers Squibb; Janssen-Cilag; MSD Oncology; Vertex
 
Nicholas C. Turner
Consulting or Advisory Role - ADC Therapeutics; AstraZeneca; Novartis; Pfizer; Puma Biotechnology; Roche; SERVIER; Synthon
Research Funding - AstraZeneca (Inst); Clovis Oncology (Inst); Inivata (Inst); Pfizer (Inst); Roche (Inst)