|
A randomized, double-blinded, controlled study of tucatinib (ONT-380) vs. placebo in combination with capecitabine (C) and trastuzumab (Tz) in patients with pretreated HER2+ unresectable locally advanced or metastatic breast carcinoma (mBC) (HER2CLIMB). |
|
|
Consulting or Advisory Role - Angiochem; Genentech/Roche; GERON; Kadmon; Lilly; Merrimack; Nektar; Novartis; Sanofi; to-BBB technologies BV |
Research Funding - Angiochem (Inst); Cascadian Therapeutics (Inst); Geron (Inst); Lilly (Inst); Merck (Inst); Merrimack (Inst); Nektar (Inst); Novartis (Inst); Oncothyreon (Inst); Puma Biotechnology (Inst); Sanofi (Inst); Tesaro (Inst); to-BBB technologies BV (Inst) |
Patents, Royalties, Other Intellectual Property - Jones and Bartlell; Up to Date.com |
|
|
Consulting or Advisory Role - Daiichi Sankyo; Genentech |
Research Funding - Merrimack (Inst); Oncothyreon (Inst) |
Travel, Accommodations, Expenses - Genentech/Roche; Oncothyreon |
|
|
Consulting or Advisory Role - Cascadian Therapeutics (Inst); Flatiron Health; Genentech/Roche (Inst); Pfizer (Inst) |
Research Funding - AstraZeneca (Inst); BerGenBio (Inst); Cascadian Therapeutics (Inst); Curis (Inst); Genentech/Roche (Inst); Hutchison MediPharma (Inst); Kadmon (Inst); Lilly (Inst); Lycera (Inst); MedImmune (Inst); Medivation (Inst); Mersana (Inst); Millennium (Inst); Novartis (Inst); OncoMed (Inst); Pfizer (Inst); Rgenix (Inst); Stem CentRx (Inst); Syndax (Inst); TapImmune Inc. (Inst); Tesaro (Inst); Verastem (Inst); Zymeworks (Inst) |
|
|
Research Funding - Abbott/AbbVie (Inst); Advaxis (Inst); Galena Biopharma (Inst); Incyte (Inst); Merrimack (Inst); Oncothyreon (Inst) |
|
|
Research Funding - Novartis (Inst); Roche (Inst) |
Travel, Accommodations, Expenses - Novartis |
|
|
Research Funding - Genentech/Roche (Inst); GlaxoSmithKline (Inst) |
|
|
No Relationships to Disclose |
|
|
Consulting or Advisory Role - Pfizer; Roche/Genentech |
Speakers' Bureau - Novartis; Roche/Genentech |
Travel, Accommodations, Expenses - Roche/Genentech |
|
|
Consulting or Advisory Role - AstraZeneca; Merck; NanoString Technologies; Novartis; Pfizer |
|
|
Consulting or Advisory Role - Agendia; Bayer; Celgene; Lilly; Merck; Metastat; Novartis; Peregrine Pharmaceuticals; Roche |
Research Funding - Novartis (Inst) |
Travel, Accommodations, Expenses - Novartis |
|
|
Employment - AMAG Pharmaceuticals (I) |
Leadership - AMAG Pharmaceuticals (I) |
Stock and Other Ownership Interests - AMAG Pharmaceuticals (I) |
Research Funding - Genentech |
|
|
No Relationships to Disclose |
|
|
No Relationships to Disclose |
|
|
Employment - Dava Oncology (I) |
Consulting or Advisory Role - AstraZeneca; Genentech; Novartis; Pfizer |
Expert Testimony - Novartis |
Travel, Accommodations, Expenses - Genentech; Novartis; Pfizer |
Other Relationship - AstraZeneca; Genentech; Novartis; Pfizer |
|
|
No Relationships to Disclose |
|
|
Research Funding - Amgen (Inst); Bayer (Inst); Biomarin (Inst); Boehringer Ingelheim (Inst); Cascadian Therapeutics (Inst); Dignitana (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); Lilly (Inst); Medivation (Inst); Merrimack (Inst); Novartis (Inst); OBI Pharma (Inst); Pfizer (Inst); Puma Biotechnology (Inst); sanofi (Inst) |
Travel, Accommodations, Expenses - Bayer; Lilly; Novartis; OBI Pharma |
|
|
No Relationships to Disclose |
|
|
Consulting or Advisory Role - Genentech/Roche; Leap Therapeutics; Novartis; Verastem |
Research Funding - Genentech/Roche (Inst); Novartis (Inst) |
Travel, Accommodations, Expenses - Genentech/Roche |