The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers.
 
David Michael Hyman
Consulting or Advisory Role - Atara Biotherapeutics; Chugai Pharma; CytomX Therapeutics
Research Funding - AstraZeneca; Puma Biotechnology
 
Theodore Willis Laetsch
Consulting or Advisory Role - Loxo; Novartis
Research Funding - Amgen; Lilly; Merck
Travel, Accommodations, Expenses - Celgene
 
Shivaani Kummar
Consulting or Advisory Role - Corvus Pharmaceuticals; MedTree (I)
Research Funding - Bristol-Myers Squibb (Inst); Corvus Pharmaceuticals (Inst); Dynavax Technologies (Inst); Loxo (Inst); Pfizer (Inst)
 
Steven G. DuBois
Honoraria - Loxo
Consulting or Advisory Role - Loxo
Research Funding - Curis (Inst); Lilly (Inst); Merck (Inst); Millennium (Inst); Novartis (Inst); Roche/Genentech (Inst)
Travel, Accommodations, Expenses - Loxo
 
Anna F. Farago
No Relationships to Disclose
 
Alberto S. Pappo
No Relationships to Disclose
 
George D. Demetri
Leadership - Blueprint Medicines
Stock and Other Ownership Interests - Bessor Pharma; Blueprint Medicines; Caris Life Sciences; Champions Oncology; G1 Therapeutics; N-of-One
Consulting or Advisory Role - Adaptimmune; Bayer; Blueprint Medicines; Caris Life Sciences; Daiichi Sankyo; Eisai; EMD Serono; G1 Therapeutics; Genocea Biosciences; Janssen Oncology; Kolltan Pharmaceuticals; Kyocera; Lilly; Nektar; Novartis; Pfizer; PharmaMar; Polaris; Sanofi; WIRB-Copernicus Group; ZIOPHARM Oncology
Research Funding - Abbvie (Inst); Janssen Oncology (Inst)
Patents, Royalties, Other Intellectual Property - Patent on use of imatinib for GIST, receive minor royalty payment from Dana-Farber after license between Dana-Farber and Novartis
 
Wafik S. El-Deiry
Stock and Other Ownership Interests - Oncoceutics; p53-Therapeutics
Research Funding - Morphotek
Patents, Royalties, Other Intellectual Property - I hold patents and have submitted patents relevant to my academic laboratory research. However, these patent have no relationship with my GI ASCO presentation.
Other Relationship - Caris Life Sciences
 
Ulrik Niels Lassen
No Relationships to Disclose
 
Afshin Dowlati
No Relationships to Disclose
 
Marcia S. Brose
Honoraria - Bayer; Exelixis; Onyx
Consulting or Advisory Role - AstraZeneca; Bayer; Bristol-Myers Squibb; Eisai; Exelixis; Onyx; Oxigene
Research Funding - Bayer (Inst); Eisai (Inst); Exelixis (Inst); Novartis (Inst); Roche/Genentech (Inst)
Travel, Accommodations, Expenses - Bayer; Eisai; Onyx
 
Valentina Boni
No Relationships to Disclose
 
Brian Turpin
No Relationships to Disclose
 
Ramamoorthy Nagasubramanian
Travel, Accommodations, Expenses - Loxo
 
Scott Cruickshank
Consulting or Advisory Role - Loxo
 
Michael Craig Cox
Employment - Amgen; Bayer; Loxo; Merck KGaA
Stock and Other Ownership Interests - Amgen; Bayer; Loxo; Merck KGaA
 
Nora C. Ku
Employment - Loxo
Stock and Other Ownership Interests - Loxo
 
Douglas S. Hawkins
No Relationships to Disclose
 
David S. Hong
Stock and Other Ownership Interests - MolecularMatch; Oncorena
Honoraria - Adaptimmune; Baxter; Bayer; Merrimack
Consulting or Advisory Role - Baxter; Bayer
Research Funding - Amgen; AstraZeneca; Daiichi Sankyo; Eisai; Genentech; Lilly; Merck; Mirati Therapeutics; miRNA Therapeutics; Novartis; Pfizer
Travel, Accommodations, Expenses - Loxo; miRNA Therapeutics
Other Relationship - Oncorena
 
Alexander E. Drilon
Honoraria - AstraZeneca; Blueprint Medicines; Exelixis; Genentech/Roche; Ignyta; Loxo
Consulting or Advisory Role - ARIAD
Research Funding - Foundation Medicine