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Gene-specific features (MLH1, MSH2, MSH6, PMS2) of mismatch repair (MMR) protein expression and somatic mutations (muts), microsatellite instability (MSI) and tumor mutational burden (TMB) in MSI-H and MMR-mutated tumor genomic profiles (TGPs). |
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Patents, Royalties, Other Intellectual Property - I share a patent with several Fox Chase investigators for a novel method to investigate hereditary CRC genes (Inst) |
Travel, Accommodations, Expenses - Foundation Medicine |
Other Relationship - Caris Life Sciences; Foundation Medicine; Invitae; Myriad Genetics |
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No Relationships to Disclose |
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Employment - Caris Life Sciences |
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Employment - Caris Life Sciences |
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Consulting or Advisory Role - Amgen (Inst); Array BioPharma (Inst); Bayer (Inst); Boston Biomedical (Inst); Bristol-Myers Squibb (Inst); Genentech/Roche (Inst); Guardant Health (Inst); Lilly (Inst) |
Research Funding - Bayer (Inst); Boehringer Ingelheim (Inst); Boston Biomedical (Inst); Eisai (Inst); Genentech/Roche (Inst); Lilly (Inst); Pfizer (Inst); Sanofi (Inst) |
Travel, Accommodations, Expenses - Amgen; Bayer; Boehringer Ingelheim; Boston Biomedical; Bristol-Myers Squibb; Genentech/Roche; Merck Sharp & Dohme |
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Consulting or Advisory Role - Merck; Merck KGaA; Taiho Pharmaceutical |
Research Funding - Bristol-Myers Squibb |
Travel, Accommodations, Expenses - Merck; Merck KGaA |
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No Relationships to Disclose |
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Consulting or Advisory Role - Amgen; Bayer; Boehringer Ingelheim; Bristol-Myers Squibb; Genentech/Roche; Ipsen; Lilly; Taiho Pharmaceutical |
Speakers' Bureau - Amgen; Bristol-Myers Squibb; Celgene; Genentech/Roche; Ipsen |
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Honoraria - AstraZeneca; Boehringer Ingelheim; Celgene; Lilly; Merck; Pfizer |
Consulting or Advisory Role - AstraZeneca; Boehringer Ingelheim; Celgene; Lilly; Merck; Pfizer |
Research Funding - Boehringer Ingelheim; Genentech/Roche; Ignyta; Lilly; Merck |
Travel, Accommodations, Expenses - AstraZeneca; Boehringer Ingelheim; Celgene; Lilly |
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Honoraria - Bayer; Boehringer Ingelheim; Merck Serono; Roche |
Consulting or Advisory Role - Bayer; Merck Serono; Pfizer; Roche |
Travel, Accommodations, Expenses - Bayer; Merck Serono; Roche |
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Consulting or Advisory Role - Caris Life Sciences (Inst); Gerson Lehrman Group |
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Employment - Benchling (I) |
Stock and Other Ownership Interests - Benchling (I) |
Consulting or Advisory Role - Bayer; Bristol-Myers Squibb; Endocyte; GE Healthcare; Merck; Merrimack; Personal Genome Diagnostics; Siemens Healthcare Diagnostics; Taiho Pharmaceutical |
Speakers' Bureau - GE Healthcare |
Research Funding - Bayer; Boehringer Ingelheim; Bristol-Myers Squibb; Caris Life Sciences; Eisai; H3 Biomedicine; Inovio Pharmaceuticals; Karyopharm Therapeutics; Merrimack; Novartis; OncoMed; Plexxikon; Taiho Pharmaceutical |
Travel, Accommodations, Expenses - Caris Life Sciences; Endocyte; GE Healthcare; Merrimack |
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Employment - Caris Life Sciences |
Honoraria - Amgen; Bayer/Onyx; Caris Life Sciences; Celgene; Genentech/Roche; Taiho Pharmaceutical |
Consulting or Advisory Role - Amgen; Bayer/Onyx; Caris Life Sciences; Celgene; Genentech/Roche; Taiho Pharmaceutical |
Speakers' Bureau - Amgen; Bayer/Onyx; Celgene; Genentech/Roche; Taiho Pharmaceutical |
Research Funding - Amgen (Inst); Bayer/Onyx (Inst); Boehringer Ingelheim (Inst); Genentech/Roche (Inst); MedImmune (Inst); Pfizer (Inst) |
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No Relationships to Disclose |
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Consulting or Advisory Role - Genentech/Roche; Taiho Pharmaceutical |
Speakers' Bureau - Genentech/Roche; Taiho Pharmaceutical |
Research Funding - Bayer (Inst); Taiho Pharmaceutical (Inst) |