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A phase Ib dose-escalation and cohort-expansion study of safety and activity of the transforming growth factor (TGF) β receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer. |
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Consulting or Advisory Role - Baxter; Evotec; Incyte; Lilly; Shire |
Research Funding - Celgene; Evotec; Incyte; Shire |
Travel, Accommodations, Expenses - Celgene |
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Consulting or Advisory Role - Amgen; AstraZeneca/MedImmune (Inst); Gritstone Bio; Incyte (Inst); Lilly (Inst); Spectrum Pharmaceuticals (Inst) |
Travel, Accommodations, Expenses - Amgen; AstraZeneca/MedImmune; Lilly; SERVIER |
Other Relationship - Abbvie; Agios; Amgen; argenx; Arno Therapeutics; Astex Pharmaceuticals; AstraZeneca; AVEO; Bayer; Blueprint Medicines; Boehringer Ingelheim; Bristol-Myers Squibb; Celgene; Chugai Pharma; Clovis Oncology; Daiichi Sankyo; Debiopharm Group; Eisai; Exelixis; FORMA Therapeutics; GamaMabs Pharma; Genentech; GlaxoSmithKline; H3 Biomedicine; Innate Pharma; Janssen-Cilag; Kyowa Hakko Kirin; Lilly; Loxo; Lytix Biopharma; MedImmune; Menarini; Merck Sharp & Dohme; Merrimack; Merus; Millenium Pharamceuticals; Nanobiotix; Nektar; Novartis; Octimet; Oncoethix; Onyx; Orion; Oryzon Genomics; Pfizer; Pierre Fabre; Roche; Roche/Genentech; Sanofi/Aventis; SERVIER; Taiho Pharmaceutical; Tesaro; Xencor |
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Consulting or Advisory Role - ASLAN Pharmaceuticals; AstraZeneca; Bayer; Genentech/Roche; Merck Serono; Novartis; Taiho Pharmaceutical |
Research Funding - Array BioPharma; AstraZeneca; Green Cross; Lilly; Novartis |
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Employment - HM Hospitales; START |
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Stock and Other Ownership Interests - International Cancer Consultants; Oncoart Associated; START |
Honoraria - HM Hospitales |
Consulting or Advisory Role - Abbvie; Amcure; AstraZeneca; Celgene; EUSA Pharma; Gerson Lehrman Group; Guidepoint Global; Janssen-Cilag; Nanobiotix; Novartis; Pfizer; PsiOxus Therapeutics; Roche/Genentech; Seagen; SERVIER |
Speakers' Bureau - Novartis |
Research Funding - AstraZeneca; BeiGene; Novartis; START |
Travel, Accommodations, Expenses - Roche/Genentech |
Other Relationship - Investigational Therapeutics in Oncological Sciences |
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Consulting or Advisory Role - Roche (I) |
Research Funding - BioMed Valley Discoveries; Bristol-Myers Squibb; Illumina (I); Lilly; Silenseed; Verastem |
Travel, Accommodations, Expenses - Roche (I) |
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Consulting or Advisory Role - Biogen (I); Corcep; Fujifilm; Genzyme (I); Ipsen; Novartis (I); Teva (I) |
Speakers' Bureau - Biogen (I); Genentech (I); Genzyme (I); Ipsen; Novartis (I); Taiho Pharmaceutical; Teva (I) |
Research Funding - Ambry Genetics (Inst); Bristol-Myers Squibb (Inst); Daiichi Sankyo (Inst); Idera (Inst); Lilly (Inst); MabVax (Inst); Minneamrita Therapeutics (Inst); Pharmacyclics (Inst); Samumed (Inst) |
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No Relationships to Disclose |
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No Relationships to Disclose |
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Consulting or Advisory Role - Celgene; Merck Serono; Shire |
Speakers' Bureau - Celgene |
Research Funding - Celgene |
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Consulting or Advisory Role - Amgen (Inst); Apexigen (Inst); Arch Oncology (Inst); ARMO BioSciences (Inst); Array BioPharma (Inst); AstraZeneca (Inst); Bayer (Inst); Beigene (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Celgene (Inst); Cerulean Pharma (Inst); Continuum Clinical (Inst); Cyteir (Inst); Daiichi Sankyo (Inst); EMD Serono (Inst); Five Prime Therapeutics (Inst); FORMA Therapeutics (Inst); Genentech/Roche (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); Incyte (Inst); Innate Pharma (Inst); Ipsen (Inst); Janssen (Inst); Leap Therapeutics (Inst); Lilly (Inst); Macrogenics (Inst); MedImmune (Inst); Merck (Inst); Merrimack (Inst); Moderna Therapeutics (Inst); Molecular Partners (Inst); Novartis (Inst); Oncogenex (Inst); OncoMed (Inst); Phoenix Biotech (Inst); Prelude Therapeutics (Inst); Sanofi (Inst); Seagen (Inst); Taiho Pharmaceutical (Inst); Tanabe Research (Inst); TD2 (Inst); TG Therapeutics (Inst); Tizona Therapeutics, Inc. (Inst); Tolero Pharmaceuticals (Inst); Torque (Inst) |
Research Funding - Abbott/AbbVie (Inst); Acerta Pharma (Inst); ADC Therapeutics (Inst); Agios (Inst); Amgen (Inst); Apexigen (Inst); Arch Oncology (Inst); ARMO BioSciences (Inst); Array BioPharma (Inst); Arrys Therapeutics (Inst); AstraZeneca/MedImmune (Inst); Bayer (Inst); BeiGene (Inst); Blueprint Medicines (Inst); Boehringer Ingelheim (Inst); Boston Biomedical (Inst); Bristol-Myers Squibb (Inst); Calithera Biosciences (Inst); Celgene (Inst); Celldex (Inst); cyteir (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); eFFECTOR Therapeutics (Inst); Eisai (Inst); EMD Serono (Inst); EMD Serono (Inst); Evelo Therapeutics (Inst); Five Prime Therapeutics (Inst); FORMA Therapeutics (Inst); Forty Seven (Inst); Forty Seven (Inst); Genentech/Roche (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); Gritstone Bio (Inst); Harpoon therapeutics (Inst); Harpoon therapeutics (Inst); ImClone Systems (Inst); Incyte (Inst); Innate Pharma (Inst); Innate Pharma (Inst); Ipsen (Inst); Jacobio (Inst); Janssen (Inst); Kolltan Pharmaceuticals (Inst); Leap Therapeutics (Inst); Lilly (Inst); Macrogenics (Inst); Marshall Edwards (Inst); Merck (Inst); Merrimack (Inst); Mersana (Inst); Merus (Inst); Millenium Pharamceuticals (Inst); Molecular Partners (Inst); Nektar (Inst); Novartis (Inst); Novocure (Inst); Oncogenex (Inst); OncoMed (Inst); Onyx (Inst); Pfizer (Inst); Phoenix Biotech (Inst); Pieris Pharmaceuticals (Inst); Prelude Therapeutics (Inst); Rgenix (Inst); Sanofi (Inst); Sierra Oncology (Inst); Sorrento Therapeutics (Inst); Stem CentRx (Inst); SynDevRx (Inst); Taiho Pharmaceutical (Inst); Takeda (Inst); Tarveda Therapeutics (Inst); TG Therapeutics (Inst); Tizona Therapeutics, Inc. (Inst); Torque (Inst); TRACON Pharma (Inst); Tyrogenex (Inst); Unum Therapeutics (Inst); Vyriad (Inst) |
Travel, Accommodations, Expenses - ARMO BioSciences; Boehringer Ingelheim; Bristol-Myers Squibb; Celgene; Daiichi Sankyo; FORMA Therapeutics; Gilead Sciences; Ipsen; Lilly; MedImmune; Merck; Novartis; OncoMed; Roche/Genentech; Taiho Pharmaceutical |
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Honoraria - Bayer; Blueprint Medicines; Bristol-Myers Squibb; Ipsen; Lilly; Merck Serono; MSD; Novartis |
Consulting or Advisory Role - Bayer; Blueprint Medicines; Bristol-Myers Squibb; Ipsen; Lilly; Merck Serono; MSD; Novartis |
Research Funding - Bayer; Blueprint Medicines; Bristol-Myers Squibb; Ipsen; Lilly; Merck Serono; MSD; Novartis |
Travel, Accommodations, Expenses - Bayer; Blueprint Medicines; Bristol-Myers Squibb; Ipsen; Lilly; Merck Serono; MSD; Novartis |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Lilly |
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Stock and Other Ownership Interests - Lilly; Pfizer |
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Stock and Other Ownership Interests - Lilly |
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Employment - Lilly; Taiho Pharmaceutical |
Stock and Other Ownership Interests - Lilly |
Patents, Royalties, Other Intellectual Property - Lilly |
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Employment - AstraZeneca; Immunocore |
Stock and Other Ownership Interests - AstraZeneca |
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Stock and Other Ownership Interests - Lilly |
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Travel, Accommodations, Expenses - Lilly |
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Honoraria - Advanced Accelerator Applications; AstraZeneca (I); Boehringer Ingelheim (I); Bristol-Myers Squibb; Bristol-Myers Squibb (I); Gilead Sciences (I); Ipsen; Lilly (I); Merck; Merck (I); Novartis; Pfizer; PharmaMar; PharmaMar (I); Roche; Roche (I); Sanofi; SERVIER; SERVIER (I); Sysmex (I) |
Consulting or Advisory Role - Advanced Accelerator Applications; Ipsen; Novartis; Pfizer |
Speakers' Bureau - Ipsen; Pfizer |
Research Funding - AstraZeneca; Bristol-Myers Squibb; MSD; Pfizer |
Travel, Accommodations, Expenses - Merck; Roche |