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Targeting IGF-1/2 with xentuzumab (Xe) plus enzalutamide (En) in metastatic castration-resistant prostate cancer (mCRPC) after progression on docetaxel chemotherapy (DCt) and abiraterone (Abi): Randomized phase II trial results. |
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Consulting or Advisory Role - AstraZeneca; Bayer; Bristol-Myers Squibb; Janssen Oncology; Merck; Pfizer; Pierre Fabre; Roche; Sotio |
Research Funding - Boehringer Ingelheim; Janssen-Cilag; Pierre Fabre |
Travel, Accommodations, Expenses - Bayer; Boehringer Ingelheim; Janssen-Cilag; MSD Oncology; Pfizer; Pierre Fabre; Roche |
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No Relationships to Disclose |
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Honoraria - Astellas Pharma; Bayer; Bristol-Myers Squibb; Ipsen; Janssen; Merck; Novartis; Pfizer; Pierre Fabre; Roche; Sanofi |
Consulting or Advisory Role - Bayer; Bayer; Bristol-Myers Squibb; Celgene; Eisai; Janssen-Cilag; Merck; Pfizer; Roche/Genentech; Sanofi |
Travel, Accommodations, Expenses - Ipsen; Janssen; Merck; Pfizer; Roche |
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Travel, Accommodations, Expenses - Janssen |
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Travel, Accommodations, Expenses - Merck |
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Honoraria - Daiichi Sankyo; Novartis; Roche |
Consulting or Advisory Role - Blueprint Medicines; Boehringer Ingelheim; Novartis |
Travel, Accommodations, Expenses - BeiGene; Daiichi Sankyo; Lilly; Novartis |
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No Relationships to Disclose |
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Employment - AstraZeneca/MedImmune |
Stock and Other Ownership Interests - AstraZeneca/MedImmune |
Consulting or Advisory Role - Aptus Clinical (Inst); Theradex Ltd |
Travel, Accommodations, Expenses - AstraZeneca |
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Employment - Boehringer Ingelheim |
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Employment - Boehringer Ingelheim; Staburo GmbH |
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Employment - Boehringer Ingelheim |
Patents, Royalties, Other Intellectual Property - Boehringer Ingelheim |
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Honoraria - Astellas Pharma; AstraZeneca; BioExcel; Daiichi Sankyo; Genentech/Roche; Janssen Oncology; Menarini Silicon Biosystems; Pfizer; Sanofi; Sierra Oncology |
Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Bayer; BioXCel therapeutics; Boehringer Ingelheim; Celgene; Daiichi Sankyo; Eisai; Genentech/Roche; Genmab; GlaxoSmithKline; Janssen Oncology; Menarini Silicon Biosystems; Merck Serono; Merck Sharp & Dohme; Orion; Pfizer; Sanofi; Sierra Oncology; Taiho Pharmaceutical |
Research Funding - Astex Pharmaceuticals (Inst); AstraZeneca (Inst); Bayer (Inst); Celgene (Inst); CellCentric (Inst); Daiichi Sankyo (Inst); Genentech (Inst); GlaxoSmithKline (Inst); MedImmune (Inst); Medivation (Inst); Merck Serono (Inst); Merck Sharp & Dohme (Inst); Orion (Inst); Sanofi (Inst); Sierra Oncology (Inst); Taiho Pharmaceutical (Inst) |
Patents, Royalties, Other Intellectual Property - Abiraterone Rewards to Inventors (Inst); CHK1 inhibitor (Inst); PARP inhibitors and DNA repair defects (Inst); Targeting of IL23 in prostate cancer (Inst) |
Travel, Accommodations, Expenses - Astellas Pharma; AstraZeneca; Genmab; GlaxoSmithKline; Orion; Qiagen; Sanofi; Taiho Pharmaceutical; Vertex |