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Phase 1 combination therapy with pexidartinib (PEX) and sirolimus (S) to target tumor-associated macrophages in pigmented villonodular synovitis, malignant peripheral nerve sheath tumors, and other soft tissue sarcomas. |
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Honoraria - Celgene; Exelixis; Roche/Genentech |
Consulting or Advisory Role - Exelixis; Roche/Genentech |
Research Funding - Merck (Inst); Plexxikon (Inst); Roche/Genentech (Inst) |
Travel, Accommodations, Expenses - Celgene; Exelixis; Roche/Genentech |
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Consulting or Advisory Role - Caris Life Sciences; CytRx Corporation; EMD Serono; Johnson & Johnson; Lilly/ImClone; Novartis; Plexxikon; Threshold Pharmaceuticals |
Speakers' Bureau - Caris Life Sciences; Johnson & Johnson; Lilly; Novartis |
Research Funding - Merck; Pfizer |
Expert Testimony - Me1 Patient |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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Employment - Driver Group |
Consulting or Advisory Role - Immunocore |
Travel, Accommodations, Expenses - Immunocore |
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Consulting or Advisory Role - Jackson Laboratory for Genomic Medicine; Seagen |
Research Funding - Lilly (Inst) |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Many |
Patents, Royalties, Other Intellectual Property - Multiple patents (Inst) |
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Stock and Other Ownership Interests - Abbott; Abbvie; Becton Dickinson; Bristol-Myers Squibb; GlaxoSmithKline; Johnson & Johnson; Merck; Pfizer |
Honoraria - Array BioPharma; Bayer; Daiichi Sankyo; DarwinHealth; Ellipses Pharma; Fortress Biotech; Human Longevity, Inc; Iovance Biotherapeutics; Pfizer; PTC Therapeutics; PureTech |
Consulting or Advisory Role - Array BioPharma; Bayer; Bionaut Labs; Daiichi Sankyo; DarwinHealth; Ellipses Pharma; Fortress Biotech; Gencirq; Human Longevity, Inc; Iovance Biotherapeutics; Pfizer; PTC Therapeutics; PureTech |
Research Funding - Astex Pharmaceuticals; Calithera Biosciences (Inst); Daiichi Sankyo (Inst); Fortress Biotech (Inst); Incyte (Inst); Karyopharm Therapeutics (Inst); Lilly (Inst); Merck (Inst); Novartis (Inst) |
Patents, Royalties, Other Intellectual Property - Companion diagnostics for CD4 inhibitors (Inst); patent granted to develop a new technology called PNAs for cancer therapy |
Travel, Accommodations, Expenses - Array BioPharma; Daiichi Sankyo; Iovance Biotherapeutics; PTC Therapeutics; PureTech |