Genome-wide cell-free DNA (cfDNA) methylation signatures and effect on tissue of origin (TOO) performance.

Minetta C.  Liu

Research Funding - Eisai (Inst); GRAIL (Inst); Janssen Diagnostics (Inst); Merck (Inst); Novartis (Inst); Roche/Genentech (Inst); Seagen (Inst); Tesaro (Inst)

Travel, Accommodations, Expenses - Agena Bioscience; Celgene; Cynvenio Biosystems; GRAIL; Menarini Silicon Biosystems; Merck; Pfizer

Arash  Jamshidi

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL; Illumina

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

Oliver  Venn

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

Alexander P.  Fields

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

M. Cyrus  Maher

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

Gordon  Cann

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

Hamed  Amini

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL; Illumina

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

Samuel  Gross

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

Joerg  Bredno

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

Meredith  Miller

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Jan  Schellenberger

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Patents, Royalties, Other Intellectual Property - GRAIL (Inst)

Kathryn N.  Kurtzman

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL; Illumina

Eric T.  Fung

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Tara  Maddala

No Relationships to Disclose

Geoffrey R.  Oxnard

Honoraria - Bio-Rad; Chugai Pharma; Guardant Health; Sysmex

Consulting or Advisory Role - AstraZeneca; DropWorks; GRAIL; Ignyta; Inivata; LOXO; Takeda

Patents, Royalties, Other Intellectual Property - DFCI has a patent pending titled "Non-invasive blood-based monitoring of genomic alterations in cancer", on which I am a co-author. (Inst)

Eric A.  Klein

Consulting or Advisory Role - GenomeDx; Genomic Health

Speakers' Bureau - Genomic Health

David R.  Spigel

Leadership - TriStar Centennial Medical Center

Consulting or Advisory Role - Abbvie (Inst); Amgen (Inst); AstraZeneca (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Celgene (Inst); Evelo Therapeutics (Inst); Foundation Medicine (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); Illumina (Inst); Lilly (Inst); Merck (Inst); Moderna Therapeutics (Inst); Nektar (Inst); Novartis (Inst); Pfizer (Inst); PharmaMar (Inst); Precision Oncology (Inst); Takeda (Inst); TRM Oncology (Inst)

Research Funding - Abbvie (Inst); Acerta Pharma (Inst); Aeglea Biotherapeutics (Inst); Amgen (Inst); ARMO BioSciences (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Celgene (Inst); Celldex (Inst); Clovis Oncology (Inst); Daiichi Sankyo (Inst); EMD Serono (Inst); Foundation Medicine (Inst); G1 Therapeutics (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); GRAIL (Inst); Ipsen (Inst); Lilly (Inst); Merck (Inst); Millennium (Inst); Nektar (Inst); Neon Therapeutics (Inst); Novartis (Inst); Oncogenex (Inst); Pfizer (Inst); Takeda (Inst); Tesaro (Inst); Transgene (Inst); University of Texas Southwestern Medical Center - Simmons Cancer Center (Inst)

Travel, Accommodations, Expenses - AstraZeneca; Boehringer Ingelheim; Bristol-Myers Squibb; Celgene; EMD Serono; Genentech; Genzyme; Intuitive Surgical; Lilly; Merck; Pfizer; Purdue Pharma; Spectrum Pharmaceuticals; Sysmex

Anne-Renee  Hartman

Employment - GRAIL; Myriad Genetics

Stock and Other Ownership Interests  - GRAIL; Myriad Genetics

Alex  Aravanis

Employment - GRAIL

Stock and Other Ownership Interests  - GRAIL

Michael  Seiden

Employment - McKesson; Texas Oncology (I)

Leadership - Nemucore Medical Innovations; Next Oncology; US Oncology

Stock and Other Ownership Interests  - Bristol-Myers Squibb; McKesson; Merck; Nemucore Medical Innovations

Honoraria - Bristol-Myers Squibb

Consulting or Advisory Role - Grail

Travel, Accommodations, Expenses - Bristol-Myers Squibb; Grail; McKesson