The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Phase I dose escalation of H3B-6545, a first-in-class highly Selective ERα Covalent Antagonist (SERCA), in women with ER-positive, HER2-negative breast cancer (HR+ BC).
 
Erika Paige Hamilton
Consulting or Advisory Role - Boehringer Ingelheim (Inst); Cascadian Therapeutics (Inst); Daiichi Sankyo (Inst); Eisai (Inst); Flatiron Health; Genentech/Roche (Inst); Lilly (Inst); Mersana (Inst); Pfizer (Inst); Puma Biotechnology (Inst)
Research Funding - Abbvie (Inst); Acerta Pharma (Inst); ArQule (Inst); AstraZeneca (Inst); BerGenBio (Inst); Boehringer Ingelheim (Inst); Cascadian Therapeutics (Inst); Clovis Oncology (Inst); Curis (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); Deciphera (Inst); eFFECTOR Therapeutics (Inst); Eisai (Inst); EMD Serono (Inst); Fujifilm (Inst); Genentech/Roche (Inst); H3 Biomedicine (Inst); Hutchison MediPharma (Inst); Immunomedics (Inst); InventisBio (Inst); Kadmon (Inst); Leap Therapeutics (Inst); Lilly (Inst); Lycera (Inst); Macrogenics (Inst); Mallinckrodt (Inst); MedImmune (Inst); Medivation (Inst); Mersana (Inst); Merus (Inst); Millennium (Inst); Novartis (Inst); Nucana (Inst); OncoMed (Inst); Oncothyreon (Inst); Pfizer (Inst); PharmaMar (Inst); Radius Health (Inst); Regeneron (Inst); Rgenix (Inst); Stem CentRx (Inst); Syndax (Inst); Syros Pharmaceuticals (Inst); Taiho Pharmaceutical (Inst); Takeda (Inst); TapImmune Inc. (Inst); Tesaro (Inst); TetraLogic Pharmaceuticals (Inst); Verastem (Inst); Zymeworks (Inst)
Travel, Accommodations, Expenses - Amgen; AstraZeneca; Bayer; Bristol-Myers Squibb; Clovis Oncology; Eisai; EMD Serono; Foundation Medicine; Genentech; Genentech/Roche; Genzyme; Guardant Health; Helsinn Therapeutics; HERON; Lexicon; Lilly; Lilly; Medivation; Merck; Novartis; Pfizer; Roche; Sysmex; Tesaro
 
Elizabeth Claire Dees
Consulting or Advisory Role - Novartis (I)
Research Funding - Bayer; Cerulean Pharma; Genentech/Roche; H3 Biomedicine; Lilly; Merck; Meryx Pharmaceuticals; Novartis; Pfizer
 
Judy Sing-Zan Wang
Speakers' Bureau - AstraZeneca/MedImmune
 
Amy Kim
Employment - H3 Biomedicine
 
Manav Korpal
Employment - H3 Biomedicine
 
Vicki Rimkunas
Employment - H3 Biomedicine
 
Nathalie Rioux
Employment - H3 Biomedicine
 
Joanne Schindler
Employment - H3 Biomedicine
Leadership - H3 Biomedicine
 
Dejan Juric
Consulting or Advisory Role - Eisai; EMD Serono; Genentech; Ipsen; Novartis
Research Funding - Eisai; EMD Serono; Genentech; Novartis; Placon; Takeda