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Clinical activity of avapritinib in ≥ fourth-line (4L+) and PDGFRA Exon 18 gastrointestinal stromal tumors (GIST). |
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Stock and Other Ownership Interests - MolecularMD; MolecularMD; MolecularMD; MolecularMD |
Honoraria - Novartis; Novartis; Novartis; Novartis |
Consulting or Advisory Role - Bayer; Bayer; Bayer; Bayer; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Deciphera; Deciphera; Deciphera; Deciphera; MolecularMD; MolecularMD; MolecularMD; MolecularMD; Novartis; Novartis; Novartis; Novartis; Pfizer; Pfizer; Pfizer; Pfizer |
Research Funding - Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst) |
Patents, Royalties, Other Intellectual Property - Patent on treatment of GIST-licensed to Novartis (Inst); Patent on treatment of GIST-licensed to Novartis (Inst); Patent on treatment of GIST-licensed to Novartis (Inst); Patent on treatment of GIST-licensed to Novartis (Inst) |
Expert Testimony - Novartis; Novartis; Novartis; Novartis |
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No Relationships to Disclose |
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Honoraria - Pfizer; Pfizer; Pfizer; Pfizer |
Consulting or Advisory Role - deciphera; deciphera; deciphera; deciphera |
Research Funding - Arog (Inst); Arog (Inst); Arog (Inst); Arog (Inst); ArQule; ArQule; ArQule; ArQule; Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Genmab (Inst); Genmab (Inst); Genmab (Inst); Genmab (Inst); Gradalis (Inst); Gradalis (Inst); Gradalis (Inst); Gradalis (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Springworks Therapeutics (Inst); Springworks Therapeutics (Inst); Springworks Therapeutics (Inst); Springworks Therapeutics (Inst) |
Travel, Accommodations, Expenses - Deciphera; Deciphera; Deciphera; Deciphera |
Other Relationship - NCCN; NCCN; NCCN; NCCN |
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Honoraria - Bayer; Bayer; Bayer; Bayer; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; Novartis; Novartis; Novartis; Novartis; Pfizer; Pfizer; Pfizer; Pfizer; Pharmamar; Pharmamar; Pharmamar; Pharmamar |
Consulting or Advisory Role - ADC Therapeutics; ADC Therapeutics; ADC Therapeutics; ADC Therapeutics; Bayer; Bayer; Bayer; Bayer; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Deciphera; Deciphera; Deciphera; Deciphera; Exelixis; Exelixis; Exelixis; Exelixis; Janssen-Cilag; Janssen-Cilag; Janssen-Cilag; Janssen-Cilag; Janssen-Cilag; Janssen-Cilag; Janssen-Cilag; Janssen-Cilag; Lilly; Lilly; Lilly; Lilly; Nanobiotix; Nanobiotix; Nanobiotix; Nanobiotix |
Research Funding - Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Incyte (Inst); Incyte (Inst); Incyte (Inst); Incyte (Inst); Novartis; Novartis; Novartis; Novartis |
Travel, Accommodations, Expenses - Pharmamar; Pharmamar; Pharmamar; Pharmamar |
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No Relationships to Disclose |
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Consulting or Advisory Role - Adaptimmune (Inst); Adaptimmune (Inst); Adaptimmune (Inst); Adaptimmune (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Deciphera; Deciphera; Deciphera; Deciphera; Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Eisai (Inst); Eisai (Inst); Eisai (Inst); Eisai (Inst); Ellipses Pharma (Inst); Ellipses Pharma (Inst); Ellipses Pharma (Inst); Ellipses Pharma (Inst); Exelixis; Exelixis; Exelixis; Exelixis; Genmab (Inst); Genmab (Inst); Genmab (Inst); Genmab (Inst); Intellisphere (Inst); Intellisphere (Inst); Intellisphere (Inst); Intellisphere (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Loxo (Inst); Loxo (Inst); Loxo (Inst); Loxo (Inst); Merck (Inst); Merck (Inst); Merck (Inst); Merck (Inst); Plexxikon (Inst); Plexxikon (Inst); Plexxikon (Inst); Plexxikon (Inst); SERVIER (Inst); SERVIER (Inst); SERVIER (Inst); SERVIER (Inst); Transgene (Inst); Transgene (Inst); Transgene (Inst); Transgene (Inst) |
Research Funding - Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); CoBioRes NV (Inst); CoBioRes NV (Inst); CoBioRes NV (Inst); CoBioRes NV (Inst); Eisai (Inst); Eisai (Inst); Eisai (Inst); Eisai (Inst); Exelixis (Inst); Exelixis (Inst); Exelixis (Inst); Exelixis (Inst); G1 Therapeutics (Inst); G1 Therapeutics (Inst); G1 Therapeutics (Inst); G1 Therapeutics (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); PharmaMar (Inst); PharmaMar (Inst); PharmaMar (Inst); PharmaMar (Inst); Plexxikon (Inst); Plexxikon (Inst); Plexxikon (Inst); Plexxikon (Inst) |
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Consulting or Advisory Role - Eisai; Eisai; Eisai; Eisai; Ipsen; Ipsen; Ipsen; Ipsen; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Roche; Roche; Roche; Roche |
Travel, Accommodations, Expenses - Pfizer; Pfizer; Pfizer; Pfizer |
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Stock and Other Ownership Interests - Transgene; Transgene; Transgene; Transgene |
Honoraria - Roche; Roche; Roche; Roche |
Consulting or Advisory Role - Amgen; Amgen; Amgen; Amgen; AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Bayer; Bayer; Bayer; Bayer; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; Lilly; Lilly; Lilly; Lilly; Novartis; Novartis; Novartis; Novartis; Pfizer; Pfizer; Pfizer; Pfizer; Roche; Roche; Roche; Roche; SERVIER; SERVIER; SERVIER; SERVIER; Vifor Pharma; Vifor Pharma; Vifor Pharma; Vifor Pharma |
Speakers' Bureau - Lilly; Lilly; Lilly; Lilly; Roche; Roche; Roche; Roche |
Travel, Accommodations, Expenses - Pfizer; Pfizer; Pfizer; Pfizer; PharmaMar; PharmaMar; PharmaMar; PharmaMar; Roche; Roche; Roche; Roche |
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No Relationships to Disclose |
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Honoraria - Bayer; Bayer; Bayer; Bayer |
Consulting or Advisory Role - Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Deciphera; Deciphera; Deciphera; Deciphera |
Research Funding - Bayer; Bayer; Bayer; Bayer; Deciphera; Deciphera; Deciphera; Deciphera; Pfizer; Pfizer; Pfizer; Pfizer |
Travel, Accommodations, Expenses - Bayer; Bayer; Bayer; Bayer; Lilly; Lilly; Lilly; Lilly; Novartis; Novartis; Novartis; Novartis; Pfizer; Pfizer; Pfizer; Pfizer; PharmaMar; PharmaMar; PharmaMar; PharmaMar |
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Leadership - Atropos; Atropos; Atropos; Atropos; Certis Oncology Solutions; Certis Oncology Solutions; Certis Oncology Solutions; Certis Oncology Solutions |
Stock and Other Ownership Interests - Atropos; Atropos; Atropos; Atropos; Certis Oncology Solutions; Certis Oncology Solutions; Certis Oncology Solutions; Certis Oncology Solutions |
Consulting or Advisory Role - Agios; Agios; Agios; Agios; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Eisai; Eisai; Eisai; Eisai; EMD Serono; EMD Serono; EMD Serono; EMD Serono; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; Immune Design; Immune Design; Immune Design; Immune Design; Janssen; Janssen; Janssen; Janssen; Lilly; Lilly; Lilly; Lilly; Loxo; Loxo; Loxo; Loxo; Nanocell Therapy; Nanocell Therapy; Nanocell Therapy; Nanocell Therapy; Novartis; Novartis; Novartis; Novartis |
Research Funding - BioAtla; BioAtla; BioAtla; BioAtla; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Deciphera; Deciphera; Deciphera; Deciphera; Immune Design; Immune Design; Immune Design; Immune Design; Lilly; Lilly; Lilly; Lilly; Novartis; Novartis; Novartis; Novartis; Plexxikon; Plexxikon; Plexxikon; Plexxikon; TRACON Pharma; TRACON Pharma; TRACON Pharma; TRACON Pharma |
Patents, Royalties, Other Intellectual Property - Companion Diagnostic for CDK4 inhibitors - 14/854,329; Companion Diagnostic for CDK4 inhibitors - 14/854,329; Companion Diagnostic for CDK4 inhibitors - 14/854,329; Companion Diagnostic for CDK4 inhibitors - 14/854,329 |
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Honoraria - GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline |
Consulting or Advisory Role - Janssen; Janssen; Janssen; Janssen; Lilly; Lilly; Lilly; Lilly; Novartis; Novartis; Novartis; Novartis |
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Honoraria - Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Lilly; Lilly; Lilly; Lilly; MSD; MSD; MSD; MSD; Novartis; Novartis; Novartis; Novartis; Pfizer; Pfizer; Pfizer; Pfizer; Roche; Roche; Roche; Roche |
Consulting or Advisory Role - Amgen; Amgen; Amgen; Amgen; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; MSD; MSD; MSD; MSD; Novartis; Novartis; Novartis; Novartis; Pierre Fabre; Pierre Fabre; Pierre Fabre; Pierre Fabre |
Speakers' Bureau - Lilly; Lilly; Lilly; Lilly; Novartis; Novartis; Novartis; Novartis; Pfizer; Pfizer; Pfizer; Pfizer |
Research Funding - Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Roche (Inst); Roche (Inst); Roche (Inst); Roche (Inst) |
Travel, Accommodations, Expenses - Orphan Europe; Orphan Europe; Orphan Europe; Orphan Europe; Pierre Fabre; Pierre Fabre; Pierre Fabre; Pierre Fabre |
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Consulting or Advisory Role - Bayer; Bayer; Bayer; Bayer; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Daiichi Sankyo; Epizyme; Epizyme; Epizyme; Epizyme; Immune Design; Immune Design; Immune Design; Immune Design; Janssen; Janssen; Janssen; Janssen; Lilly; Lilly; Lilly; Lilly; MaxiVax ; MaxiVax ; MaxiVax ; MaxiVax ; Novartis; Novartis; Novartis; Novartis |
Research Funding - Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst) |
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Honoraria - Amgen; Amgen; Amgen; Amgen; CytRx Corporation; CytRx Corporation; CytRx Corporation; CytRx Corporation; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; Ignyta; Ignyta; Ignyta; Ignyta; Immune Design; Immune Design; Immune Design; Immune Design; Janssen; Janssen; Janssen; Janssen; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Roche; Roche; Roche; Roche; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; Threshold Pharmaceuticals; Threshold Pharmaceuticals; Threshold Pharmaceuticals; Threshold Pharmaceuticals; TRACON Pharma; TRACON Pharma; TRACON Pharma; TRACON Pharma |
Consulting or Advisory Role - Amgen; Amgen; Amgen; Amgen; CytRx Corporation; CytRx Corporation; CytRx Corporation; CytRx Corporation; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; Ignyta; Ignyta; Ignyta; Ignyta; Immune Design; Immune Design; Immune Design; Immune Design; Janssen; Janssen; Janssen; Janssen; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Roche; Roche; Roche; Roche; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; Threshold Pharmaceuticals; Threshold Pharmaceuticals; Threshold Pharmaceuticals; Threshold Pharmaceuticals; TRACON Pharma; TRACON Pharma; TRACON Pharma; TRACON Pharma |
Speakers' Bureau - Amgen; Amgen; Amgen; Amgen; CytRx Corporation; CytRx Corporation; CytRx Corporation; CytRx Corporation; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; Ignyta; Ignyta; Ignyta; Ignyta; Immune Design; Immune Design; Immune Design; Immune Design; Janssen; Janssen; Janssen; Janssen; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Roche; Roche; Roche; Roche; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; Threshold Pharmaceuticals; Threshold Pharmaceuticals; Threshold Pharmaceuticals; Threshold Pharmaceuticals; TRACON Pharma; TRACON Pharma; TRACON Pharma; TRACON Pharma |
Research Funding - Amgen; Amgen; Amgen; Amgen; CytRx Corporation; CytRx Corporation; CytRx Corporation; CytRx Corporation; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; Ignyta; Ignyta; Ignyta; Ignyta; Immune Design; Immune Design; Immune Design; Immune Design; Janssen; Janssen; Janssen; Janssen; Janssen; Janssen; Janssen; Janssen; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Roche; Roche; Roche; Roche; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; SARC: Sarcoma Alliance for Research though Collaboration; Threshold Pharmaceuticals; Threshold Pharmaceuticals; Threshold Pharmaceuticals; Threshold Pharmaceuticals; TRACON Pharma; TRACON Pharma; TRACON Pharma; TRACON Pharma |
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Employment - Cancer Treament Centers of America; Cancer Treament Centers of America; Cancer Treament Centers of America; Cancer Treament Centers of America; Cancer Treament Centers of America (I); Cancer Treament Centers of America (I); Cancer Treament Centers of America (I); Cancer Treament Centers of America (I) |
Consulting or Advisory Role - Amgen; Amgen; Amgen; Amgen |
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Employment - Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines |
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Employment - Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines |
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Stock and Other Ownership Interests - Abbott Laboratories; Abbott Laboratories; Abbott Laboratories; Abbott Laboratories; Abbvie (I); Abbvie (I); Abbvie (I); Abbvie (I); Allergan (I); Allergan (I); Allergan (I); Allergan (I) |
Consulting or Advisory Role - Bayer; Bayer; Bayer; Bayer; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Blueprint Medicines; Deciphera; Deciphera; Deciphera; Deciphera; Lilly; Lilly; Lilly; Lilly; MORE Health; MORE Health; MORE Health; MORE Health; Research to Practice; Research to Practice; Research to Practice; Research to Practice; UpToDate; UpToDate; UpToDate; UpToDate |
Research Funding - ARIAD (Inst); ARIAD (Inst); ARIAD (Inst); ARIAD (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst) |
Expert Testimony - Bayer; Bayer; Bayer; Bayer |