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Ramucirumab (RAM) or merestinib (MER) or placebo (PL) plus gemcitabine (GEM) and cisplatin (CIS) as first-line treatment for advanced or metastatic biliary tract cancer (BTC): A randomized, double-blind, phase II study. |
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Honoraria - Ipsen; Ipsen; Ipsen; Ipsen |
Consulting or Advisory Role - Agios; Agios; Agios; Agios; AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Debiopharm Group; Debiopharm Group; Debiopharm Group; Debiopharm Group; Delcath Systems; Delcath Systems; Delcath Systems; Delcath Systems; Genoscience Pharma; Genoscience Pharma; Genoscience Pharma; Genoscience Pharma; Incyte; Incyte; Incyte; Incyte; Ipsen; Ipsen; Ipsen; Ipsen; Keocyt; Keocyt; Keocyt; Keocyt; Merck; Merck; Merck; Merck; Mundipharma; Mundipharma; Mundipharma; Mundipharma; Novartis; Novartis; Novartis; Novartis; Nucana; Nucana; Nucana; Nucana; PCI Biotech; PCI Biotech; PCI Biotech; PCI Biotech; Pfizer; Pfizer; Pfizer; Pfizer; Pieris Pharmaceuticals; Pieris Pharmaceuticals; Pieris Pharmaceuticals; Pieris Pharmaceuticals; QED Therapeutics; QED Therapeutics; QED Therapeutics; QED Therapeutics; SERVIER; SERVIER; SERVIER; SERVIER; Wren Laboratories; Wren Laboratories; Wren Laboratories; Wren Laboratories |
Speakers' Bureau - Imaging Equipment Limited; Imaging Equipment Limited; Imaging Equipment Limited; Imaging Equipment Limited; Ipsen; Ipsen; Ipsen; Ipsen; Novartis; Novartis; Novartis; Novartis; Nucana; Nucana; Nucana; Nucana |
Research Funding - Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst) |
Travel, Accommodations, Expenses - Celgene; Celgene; Celgene; Celgene; Nucana; Nucana; Nucana; Nucana; Pfizer; Pfizer; Pfizer; Pfizer |
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Honoraria - Lilly; Lilly; Lilly; Lilly; MSD; MSD; MSD; MSD; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; Pfizer; Pfizer; Pfizer; Pfizer; SynCoreBio; SynCoreBio; SynCoreBio; SynCoreBio |
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No Relationships to Disclose |
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Consulting or Advisory Role - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Bayer; Bayer; Bayer; Bayer; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Celgene; Celgene; Celgene; Celgene; Halozyme; Halozyme; Halozyme; Halozyme; Lilly; Lilly; Lilly; Lilly; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; Merck Sharp & Dohme; Merck Sharp & Dohme; Merck Sharp & Dohme; Merck Sharp & Dohme; Novartis; Novartis; Novartis; Novartis; Roche; Roche; Roche; Roche; SERVIER; SERVIER; SERVIER; SERVIER |
Research Funding - amgen (Inst); amgen (Inst); amgen (Inst); amgen (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Celgene (Inst); Celgene (Inst); Celgene (Inst); Celgene (Inst); Ipsen (Inst); Ipsen (Inst); Ipsen (Inst); Ipsen (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Merck (Inst); Merck (Inst); Merck (Inst); Merck (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Roche (Inst); Roche (Inst); Roche (Inst); Roche (Inst); SERVIER (Inst); SERVIER (Inst); SERVIER (Inst); SERVIER (Inst) |
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Consulting or Advisory Role - Bayer; Bayer; Bayer; Bayer; Celgene; Celgene; Celgene; Celgene |
Research Funding - Agios; Agios; Agios; Agios; ASLAN Pharmaceuticals; ASLAN Pharmaceuticals; ASLAN Pharmaceuticals; ASLAN Pharmaceuticals; Lilly; Lilly; Lilly; Lilly |
Travel, Accommodations, Expenses - Acraf; Acraf; Acraf; Acraf; Merck Serono; Merck Serono; Merck Serono; Merck Serono |
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Honoraria - AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Lilly; Lilly; Lilly; Lilly; MSD; MSD; MSD; MSD; Novartis; Novartis; Novartis; Novartis; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; PharmaEngine; PharmaEngine; PharmaEngine; PharmaEngine; TTY Biopharm; TTY Biopharm; TTY Biopharm; TTY Biopharm |
Consulting or Advisory Role - AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Five Prime Therapeutics; Five Prime Therapeutics; Five Prime Therapeutics; Five Prime Therapeutics; Lilly; Lilly; Lilly; Lilly; MSD; MSD; MSD; MSD; Novartis; Novartis; Novartis; Novartis; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; PharmaEngine; PharmaEngine; PharmaEngine; PharmaEngine; SynCoreBio; SynCoreBio; SynCoreBio; SynCoreBio; TTY Biopharm; TTY Biopharm; TTY Biopharm; TTY Biopharm |
Research Funding - Celgene (Inst); Celgene (Inst); Celgene (Inst); Celgene (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); Merck Serono (Inst); Merck Serono (Inst); Merck Serono (Inst); Merck Serono (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Polaris (Inst); Polaris (Inst); Polaris (Inst); Polaris (Inst); SynCoreBio (Inst); SynCoreBio (Inst); SynCoreBio (Inst); SynCoreBio (Inst); TTY Biopharm (Inst); TTY Biopharm (Inst); TTY Biopharm (Inst); TTY Biopharm (Inst) |
Patents, Royalties, Other Intellectual Property - anti-alpha-enolase (ENO-1) monoclonal antibody to HuniLife Technology, Taiwan; anti-alpha-enolase (ENO-1) monoclonal antibody to HuniLife Technology, Taiwan; anti-alpha-enolase (ENO-1) monoclonal antibody to HuniLife Technology, Taiwan; anti-alpha-enolase (ENO-1) monoclonal antibody to HuniLife Technology, Taiwan |
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Consulting or Advisory Role - Lilly; Lilly; Lilly; Lilly; Merck; Merck; Merck; Merck; SERVIER; SERVIER; SERVIER; SERVIER |
Speakers' Bureau - Amgen; Amgen; Amgen; Amgen; Lilly; Lilly; Lilly; Lilly; Merck; Merck; Merck; Merck; SERVIER; SERVIER; SERVIER; SERVIER |
Research Funding - Merck; Merck; Merck; Merck |
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Consulting or Advisory Role - Bayer; Bayer; Bayer; Bayer; Bayer; Bayer; Bayer; Bayer; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Lilly; Lilly; Lilly; Lilly; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Novartis; Novartis; Novartis; Novartis; Novartis; Novartis; Novartis; Novartis; Pfizer; Pfizer; Pfizer; Pfizer; Roche; Roche; Roche; Roche; Roche; Roche; Roche; Roche; Sanofi; Sanofi; Sanofi; Sanofi; Sanofi; Sanofi; Sanofi; Sanofi |
Speakers' Bureau - Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Celgene; Celgene; Celgene; Celgene; Celgene; Celgene; Celgene; Celgene; Sanofi; Sanofi; Sanofi; Sanofi |
Research Funding - Baxalta/Shire; Baxalta/Shire; Baxalta/Shire; Baxalta/Shire |
Travel, Accommodations, Expenses - Ipsen; Ipsen; Ipsen; Ipsen; Ipsen; Ipsen; Ipsen; Ipsen |
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Consulting or Advisory Role - Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical |
Research Funding - AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Lilly; Lilly; Lilly; Lilly; MedImmune; MedImmune; MedImmune; MedImmune; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; MSD Oncology; MSD Oncology; MSD Oncology; MSD Oncology; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; Ono Pharmaceutical; Roche; Roche; Roche; Roche; TTY Biopharm; TTY Biopharm; TTY Biopharm; TTY Biopharm |
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Honoraria - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; Celgene; Celgene; Celgene; Celgene; ERYTECH Pharma; ERYTECH Pharma; ERYTECH Pharma; ERYTECH Pharma; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; Roche/Genentech; Roche/Genentech; Roche/Genentech; Roche/Genentech; Servier; Servier; Servier; Servier; Shire; Shire; Shire; Shire; Sirtex Medical; Sirtex Medical; Sirtex Medical; Sirtex Medical |
Consulting or Advisory Role - ERYTECH Pharma; ERYTECH Pharma; ERYTECH Pharma; ERYTECH Pharma; Incyte; Incyte; Incyte; Incyte; Pierre Fabre; Pierre Fabre; Pierre Fabre; Pierre Fabre; Roche Pharma AG; Roche Pharma AG; Roche Pharma AG; Roche Pharma AG; Shire; Shire; Shire; Shire; Sirtex medical; Sirtex medical; Sirtex medical; Sirtex medical |
Speakers' Bureau - Celgene; Celgene; Celgene; Celgene; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; SERVIER; SERVIER; SERVIER; SERVIER; Sirtex Medical; Sirtex Medical; Sirtex Medical; Sirtex Medical |
Research Funding - Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Sirtex Medical (Inst); Sirtex Medical (Inst); Sirtex Medical (Inst); Sirtex Medical (Inst) |
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Consulting or Advisory Role - Astellas Pharma; Astellas Pharma; Astellas Pharma; Astellas Pharma; Bayer; Bayer; Bayer; Bayer; BeiGene; BeiGene; BeiGene; BeiGene; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Exelixis; Exelixis; Exelixis; Exelixis; Merck; Merck; Merck; Merck |
Research Funding - Advaxis (Inst); Advaxis (Inst); Advaxis (Inst); Advaxis (Inst); Agios (Inst); Agios (Inst); Agios (Inst); Agios (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Array BioPharma (Inst); AstraZeneca (Inst); AstraZeneca (Inst); AstraZeneca (Inst); AstraZeneca (Inst); BeiGene (Inst); BeiGene (Inst); BeiGene (Inst); BeiGene (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Exelixis (Inst); Exelixis (Inst); Exelixis (Inst); Exelixis (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lycera (Inst); Lycera (Inst); Lycera (Inst); Lycera (Inst); Macrogenics (Inst); Macrogenics (Inst); Macrogenics (Inst); Macrogenics (Inst); MedImmune (Inst); MedImmune (Inst); MedImmune (Inst); MedImmune (Inst); Merrimack (Inst); Merrimack (Inst); Merrimack (Inst); Merrimack (Inst); Sanofi (Inst); Sanofi (Inst); Sanofi (Inst); Sanofi (Inst); Zymeworks (Inst); Zymeworks (Inst); Zymeworks (Inst); Zymeworks (Inst) |
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Honoraria - Amgen; Amgen; Amgen; Amgen; Bayer; Bayer; Bayer; Bayer; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Delcath Systems; Delcath Systems; Delcath Systems; Delcath Systems; Lilly; Lilly; Lilly; Lilly; MSD; MSD; MSD; MSD; Novartis; Novartis; Novartis; Novartis; Roche; Roche; Roche; Roche; Sanofi; Sanofi; Sanofi; Sanofi |
Consulting or Advisory Role - Amgen; Amgen; Amgen; Amgen; Baxalta; Baxalta; Baxalta; Baxalta; Bayer; Bayer; Bayer; Bayer; Delcath Systems; Delcath Systems; Delcath Systems; Delcath Systems; Lilly; Lilly; Lilly; Lilly; Novartis; Novartis; Novartis; Novartis; Roche; Roche; Roche; Roche |
Research Funding - Novartis; Novartis; Novartis; Novartis |
Travel, Accommodations, Expenses - Bayer; Bayer; Bayer; Bayer; Ipsen; Ipsen; Ipsen; Ipsen; Roche; Roche; Roche; Roche |
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Consulting or Advisory Role - Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Genentech; Genentech; Genentech; Genentech; Merck; Merck; Merck; Merck |
Speakers' Bureau - Bayer; Bayer; Bayer; Bayer; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Eisai; Eisai; Eisai; Eisai; Exelis; Exelis; Exelis; Exelis |
Research Funding - Genentech; Genentech; Genentech; Genentech; Merck; Merck; Merck; Merck |
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Employment - Lilly; Lilly; Lilly; Lilly |
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Employment - Lilly; Lilly; Lilly; Lilly |
Stock and Other Ownership Interests - Lilly; Lilly; Lilly; Lilly |
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Employment - Lilly; Lilly; Lilly; Lilly |
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Employment - Lilly; Lilly; Lilly; Lilly |
Stock and Other Ownership Interests - Lilly; Lilly; Lilly; Lilly |
Patents, Royalties, Other Intellectual Property - Patent applicant/holder, without royalties, for therapeutic applications related to ramucirumab and merestinib. (Inst); Patent applicant/holder, without royalties, for therapeutic applications related to ramucirumab and merestinib. (Inst); Patent applicant/holder, without royalties, for therapeutic applications related to ramucirumab and merestinib. (Inst); Patent applicant/holder, without royalties, for therapeutic applications related to ramucirumab and merestinib. (Inst) |
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No Relationships to Disclose |
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Consulting or Advisory Role - ASLAN Pharmaceuticals; ASLAN Pharmaceuticals; ASLAN Pharmaceuticals; ASLAN Pharmaceuticals; AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Bayer; Bayer; Bayer; Bayer; Genentech/Roche; Genentech/Roche; Genentech/Roche; Genentech/Roche; Halozyme; Halozyme; Halozyme; Halozyme; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Novartis; Novartis; Novartis; Novartis; Taiho Pharmaceutical; Taiho Pharmaceutical; Taiho Pharmaceutical; Taiho Pharmaceutical; Zymeworks; Zymeworks; Zymeworks; Zymeworks |
Research Funding - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Lilly; Lilly; Lilly; Lilly |