The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Encorafenib plus cetuximab with or without binimetinib for BRAF V600E-mutant metastatic colorectal cancer: Quality-of-life results from a randomized, three-arm, phase III study versus the choice of either irinotecan or FOLFIRI plus cetuximab (BEACON CRC).
 
Scott Kopetz
Stock and Other Ownership Interests - MolecularMatch; MolecularMatch; MolecularMatch; MolecularMatch; Navire; Navire; Navire; Navire
Consulting or Advisory Role - Amal Therapeutics; Amal Therapeutics; Amal Therapeutics; Amal Therapeutics; Amgen; Amgen; Amgen; Amgen; AstraZeneca/MedImmune; AstraZeneca/MedImmune; AstraZeneca/MedImmune; AstraZeneca/MedImmune; Bayer Health; Bayer Health; Bayer Health; Bayer Health; Biocartis; Biocartis; Biocartis; Biocartis; Boehringer Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim; Boston Biomedical; Boston Biomedical; Boston Biomedical; Boston Biomedical; EMD Serono; EMD Serono; EMD Serono; EMD Serono; EMD Serono; EMD Serono; EMD Serono; EMD Serono; Genentech; Genentech; Genentech; Genentech; Holy Stone; Holy Stone; Holy Stone; Holy Stone; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Karyopharm Therapeutics; Lilly; Lilly; Lilly; Lilly; Merck; Merck; Merck; Merck; Navire Pharma; Navire Pharma; Navire Pharma; Navire Pharma; Novartis; Novartis; Novartis; Novartis; Pierre Fabre; Pierre Fabre; Pierre Fabre; Pierre Fabre; Redx Pharma; Redx Pharma; Redx Pharma; Redx Pharma; Roche; Roche; Roche; Roche; Symphogen; Symphogen; Symphogen; Symphogen
Research Funding - Amgen (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Biocartis (Inst); Biocartis (Inst); Biocartis (Inst); Biocartis (Inst); EMD Serono (Inst); EMD Serono (Inst); EMD Serono (Inst); EMD Serono (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Guardant Health (Inst); Guardant Health (Inst); Guardant Health (Inst); Guardant Health (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); MedImmune (Inst); MedImmune (Inst); MedImmune (Inst); MedImmune (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Sanofi (Inst); Sanofi (Inst); Sanofi (Inst); Sanofi (Inst)
 
Axel Grothey
Honoraria - Aptitude Health; Aptitude Health; Aptitude Health; Aptitude Health; Elsevier; Elsevier; Elsevier; Elsevier; IMEDEX; IMEDEX; IMEDEX; IMEDEX
Consulting or Advisory Role - Amgen (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Boston Biomedical (Inst); Boston Biomedical (Inst); Boston Biomedical (Inst); Boston Biomedical (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Guardant Health (Inst); Guardant Health (Inst); Guardant Health (Inst); Guardant Health (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst)
Research Funding - Array BioPharma (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Array BioPharma (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Boston Biomedical (Inst); Boston Biomedical (Inst); Boston Biomedical (Inst); Boston Biomedical (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); Eisai (Inst); Eisai (Inst); Eisai (Inst); Eisai (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst)
Travel, Accommodations, Expenses - Amgen; Amgen; Amgen; Amgen; Bayer; Bayer; Bayer; Bayer; Boehringer Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim; Boston Biomedical; Boston Biomedical; Boston Biomedical; Boston Biomedical; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Genentech/Roche; Genentech/Roche; Genentech/Roche; Genentech/Roche; Merck Sharp & Dohme; Merck Sharp & Dohme; Merck Sharp & Dohme; Merck Sharp & Dohme
 
Eric Van Cutsem
Consulting or Advisory Role - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Bayer; Bayer; Bayer; Bayer; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb; Celgene; Celgene; Celgene; Celgene; Halozyme; Halozyme; Halozyme; Halozyme; Lilly; Lilly; Lilly; Lilly; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; Merck Sharp & Dohme; Merck Sharp & Dohme; Merck Sharp & Dohme; Merck Sharp & Dohme; Novartis; Novartis; Novartis; Novartis; Roche; Roche; Roche; Roche; SERVIER; SERVIER; SERVIER; SERVIER
Research Funding - amgen (Inst); amgen (Inst); amgen (Inst); amgen (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Celgene (Inst); Celgene (Inst); Celgene (Inst); Celgene (Inst); Ipsen (Inst); Ipsen (Inst); Ipsen (Inst); Ipsen (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Merck (Inst); Merck (Inst); Merck (Inst); Merck (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Roche (Inst); Roche (Inst); Roche (Inst); Roche (Inst); SERVIER (Inst); SERVIER (Inst); SERVIER (Inst); SERVIER (Inst)
 
Rona Yaeger
Research Funding - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; Boehringer Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; Novartis; Novartis; Novartis; Novartis
Travel, Accommodations, Expenses - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma
 
Harpreet Singh Wasan
Honoraria - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; Celgene; Celgene; Celgene; Celgene; ERYTECH Pharma; ERYTECH Pharma; ERYTECH Pharma; ERYTECH Pharma; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; Roche/Genentech; Roche/Genentech; Roche/Genentech; Roche/Genentech; Servier; Servier; Servier; Servier; Shire; Shire; Shire; Shire; Sirtex Medical; Sirtex Medical; Sirtex Medical; Sirtex Medical
Consulting or Advisory Role - ERYTECH Pharma; ERYTECH Pharma; ERYTECH Pharma; ERYTECH Pharma; Incyte; Incyte; Incyte; Incyte; Pierre Fabre; Pierre Fabre; Pierre Fabre; Pierre Fabre; Roche Pharma AG; Roche Pharma AG; Roche Pharma AG; Roche Pharma AG; Shire; Shire; Shire; Shire; Sirtex medical; Sirtex medical; Sirtex medical; Sirtex medical
Speakers' Bureau - Celgene; Celgene; Celgene; Celgene; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; SERVIER; SERVIER; SERVIER; SERVIER; Sirtex Medical; Sirtex Medical; Sirtex Medical; Sirtex Medical
Research Funding - Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Sirtex Medical (Inst); Sirtex Medical (Inst); Sirtex Medical (Inst); Sirtex Medical (Inst)
 
Takayuki Yoshino
Research Funding - Chugai Pharma (Inst); Chugai Pharma (Inst); Chugai Pharma (Inst); Chugai Pharma (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); Daiichi Sankyo (Inst); GlaxoSmithKline plc (Inst); GlaxoSmithKline plc (Inst); GlaxoSmithKline plc (Inst); GlaxoSmithKline plc (Inst); MSD.K.K. (Inst); MSD.K.K. (Inst); MSD.K.K. (Inst); MSD.K.K. (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Ono Pharmaceutical (Inst); Ono Pharmaceutical (Inst); Ono Pharmaceutical (Inst); Ono Pharmaceutical (Inst); PAREXEL International Inc. (Inst); PAREXEL International Inc. (Inst); PAREXEL International Inc. (Inst); PAREXEL International Inc. (Inst); Sanofi (Inst); Sanofi (Inst); Sanofi (Inst); Sanofi (Inst); Sumitomo Dainippon (Inst); Sumitomo Dainippon (Inst); Sumitomo Dainippon (Inst); Sumitomo Dainippon (Inst)
 
Jayesh Desai
Consulting or Advisory Role - Amgen (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); BeiGene; BeiGene; BeiGene; BeiGene; Biocon; Biocon; Biocon; Biocon; Eisai; Eisai; Eisai; Eisai; Lilly; Lilly; Lilly; Lilly
Research Funding - AstraZeneca/MedImmune (Inst); AstraZeneca/MedImmune (Inst); AstraZeneca/MedImmune (Inst); AstraZeneca/MedImmune (Inst); BeiGene (Inst); BeiGene (Inst); BeiGene (Inst); BeiGene (Inst); Bionomics (Inst); Bionomics (Inst); Bionomics (Inst); Bionomics (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Roche (Inst); Roche (Inst); Roche (Inst); Roche (Inst)
 
Fortunato Ciardiello
Consulting or Advisory Role - Amgen; Amgen; Amgen; Amgen; Bayer; Bayer; Bayer; Bayer; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; Pfizer; Pfizer; Pfizer; Pfizer; Roche/Genentech; Roche/Genentech; Roche/Genentech; Roche/Genentech
Research Funding - Amgen (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Ipsen (Inst); Ipsen (Inst); Ipsen (Inst); Ipsen (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck KGaA (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Roche/Genentech (Inst); Roche/Genentech (Inst); Roche/Genentech (Inst); Roche/Genentech (Inst); SERVIER (Inst); SERVIER (Inst); SERVIER (Inst); SERVIER (Inst); Symphogen (Inst); Symphogen (Inst); Symphogen (Inst); Symphogen (Inst)
 
Fotios Loupakis
Consulting or Advisory Role - Amgen; Amgen; Amgen; Amgen; Bayer; Bayer; Bayer; Bayer; Sanofi; Sanofi; Sanofi; Sanofi
Speakers' Bureau - Amgen; Amgen; Amgen; Amgen; Bayer; Bayer; Bayer; Bayer; Roche; Roche; Roche; Roche; Sanofi; Sanofi; Sanofi; Sanofi
Research Funding - Amgen (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Merck Serono (Inst); Merck Serono (Inst); Merck Serono (Inst); Merck Serono (Inst); Roche (Inst); Roche (Inst); Roche (Inst); Roche (Inst)
Travel, Accommodations, Expenses - Amgen; Amgen; Amgen; Amgen; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Roche; Roche; Roche; Roche
 
Yong Sang Hong
Research Funding - Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst)
 
Neeltje Steeghs
Research Funding - AB Science (Inst); AB Science (Inst); AB Science (Inst); AB Science (Inst); Abbvie (Inst); Abbvie (Inst); Abbvie (Inst); Abbvie (Inst); Actuate Therapeutics (Inst); Actuate Therapeutics (Inst); Actuate Therapeutics (Inst); Actuate Therapeutics (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); Amgen (Inst); AstraZeneca/MedImmune (Inst); AstraZeneca/MedImmune (Inst); AstraZeneca/MedImmune (Inst); AstraZeneca/MedImmune (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Bayer (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Blueprint Medicines (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Cytovation (Inst); Cytovation (Inst); Cytovation (Inst); Cytovation (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Deciphera (Inst); Genentech (Inst); Genentech (Inst); Genentech (Inst); Genentech (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); GlaxoSmithKline (Inst); Incyte (Inst); Incyte (Inst); Incyte (Inst); Incyte (Inst); InteRNA (Inst); InteRNA (Inst); InteRNA (Inst); InteRNA (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Lilly (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merck Sharp & Dohme (Inst); Merus (Inst); Merus (Inst); Merus (Inst); Merus (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Pfizer (Inst); Pierre Fabre (Inst); Pierre Fabre (Inst); Pierre Fabre (Inst); Pierre Fabre (Inst); Roche (Inst); Roche (Inst); Roche (Inst); Roche (Inst); Sanofi (Inst); Sanofi (Inst); Sanofi (Inst); Sanofi (Inst)
 
Tormod Kyrre Guren
No Relationships to Disclose
 
Hendrik-Tobias Arkenau
Employment - Hospital Corporation of America; Hospital Corporation of America; Hospital Corporation of America; Hospital Corporation of America
Honoraria - BeiGene; BeiGene; BeiGene; BeiGene; Bicycle Therapeutics; Bicycle Therapeutics; Bicycle Therapeutics; Bicycle Therapeutics; Guardant Health; Guardant Health; Guardant Health; Guardant Health; Merck KGaA; Merck KGaA; Merck KGaA; Merck KGaA; Roche; Roche; Roche; Roche; SERVIER; SERVIER; SERVIER; SERVIER
 
Pilar Garcia-Alfonso
Consulting or Advisory Role - Amgen; Amgen; Amgen; Amgen; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Roche; Roche; Roche; Roche; Sanofi; Sanofi; Sanofi; Sanofi; SERVIER; SERVIER; SERVIER; SERVIER
Speakers' Bureau - Amgen; Amgen; Amgen; Amgen; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Roche; Roche; Roche; Roche; Sanofi; Sanofi; Sanofi; Sanofi; SERVIER; SERVIER; SERVIER; SERVIER
Travel, Accommodations, Expenses - Merck Serono; Merck Serono; Merck Serono; Merck Serono; Roche; Roche; Roche; Roche
 
Ashwin Gollerkeri
Employment - Alnylam (I); Alnylam (I); Alnylam (I); Alnylam (I); Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; Bluebird Bio (I); Bluebird Bio (I); Bluebird Bio (I); Bluebird Bio (I)
Stock and Other Ownership Interests - Alnylam (I); Alnylam (I); Alnylam (I); Alnylam (I); Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; Bluebird Bio (I); Bluebird Bio (I); Bluebird Bio (I); Bluebird Bio (I)
Patents, Royalties, Other Intellectual Property - Receives royalties from Yale University on an antibody used in nephrology basic research. (I); Receives royalties from Yale University on an antibody used in nephrology basic research. (I); Receives royalties from Yale University on an antibody used in nephrology basic research. (I); Receives royalties from Yale University on an antibody used in nephrology basic research. (I)
 
Kati Maharry
Employment - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma
Stock and Other Ownership Interests - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma
Travel, Accommodations, Expenses - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma
 
Janna Christy-Bittel
Employment - Array Biopharma; Array Biopharma; Array Biopharma; Array Biopharma
Stock and Other Ownership Interests - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; Gilead Sciences; Gilead Sciences; Gilead Sciences; Gilead Sciences
 
Christopher Hunt Keir
Employment - Pfizer; Pfizer; Pfizer; Pfizer
Stock and Other Ownership Interests - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma
 
Michael D Pickard
Employment - Pfizer; Pfizer; Pfizer; Pfizer
Stock and Other Ownership Interests - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma
 
Josep Tabernero
Consulting or Advisory Role - Array BioPharma; Array BioPharma; Array BioPharma; Array BioPharma; AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca; Bayer; Bayer; Bayer; Bayer; BeiGene; BeiGene; BeiGene; BeiGene; Biocartis; Biocartis; Biocartis; Biocartis; Boehringer Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim; Chugai Pharma; Chugai Pharma; Chugai Pharma; Chugai Pharma; Foundation Medicine; Foundation Medicine; Foundation Medicine; Foundation Medicine; Genentech; Genentech; Genentech; Genentech; Genmab; Genmab; Genmab; Genmab; HalioDX SAS; HalioDX SAS; HalioDX SAS; HalioDX SAS; Halozyme; Halozyme; Halozyme; Halozyme; Imugene Limited; Imugene Limited; Imugene Limited; Imugene Limited; Inflection Biosciences Limited; Inflection Biosciences Limited; Inflection Biosciences Limited; Inflection Biosciences Limited; Ipsen; Ipsen; Ipsen; Ipsen; Kura; Kura; Kura; Kura; Lilly; Lilly; Lilly; Lilly; Menarini; Menarini; Menarini; Menarini; Merck Serono; Merck Serono; Merck Serono; Merck Serono; Merrimack; Merrimack; Merrimack; Merrimack; Merus; Merus; Merus; Merus; Molecular Partners; Molecular Partners; Molecular Partners; Molecular Partners; MSD; MSD; MSD; MSD; Novartis; Novartis; Novartis; Novartis; Peptomyc; Peptomyc; Peptomyc; Peptomyc; Pfizer; Pfizer; Pfizer; Pfizer; Pharmacyclics; Pharmacyclics; Pharmacyclics; Pharmacyclics; ProteoDesign SL; ProteoDesign SL; ProteoDesign SL; ProteoDesign SL; Rafael Pharmaceuticals; Rafael Pharmaceuticals; Rafael Pharmaceuticals; Rafael Pharmaceuticals; Roche; Roche; Roche; Roche; Roche Diagnostics; Roche Diagnostics; Roche Diagnostics; Roche Diagnostics; Sanofi; Sanofi; Sanofi; Sanofi; Seattle Genetics; Seattle Genetics; Seattle Genetics; Seattle Genetics; Seattle Genetics; Seattle Genetics; Seattle Genetics; Seattle Genetics; Servier; Servier; Servier; Servier; Symphogen; Symphogen; Symphogen; Symphogen; Taiho Pharmaceutical; Taiho Pharmaceutical; Taiho Pharmaceutical; Taiho Pharmaceutical; VCN Biosciences; VCN Biosciences; VCN Biosciences; VCN Biosciences