The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Population pharmacokinetic (PK) and exposure-response analyses from the pivotal ALTA-1L study: Model-based analyses supporting the brigatinib dose in patients with anaplastic lymphoma kinase (ALK)–positive non–small cell lung cancer (NSCLC).
 
Neeraj Gupta
Employment - Takeda
 
Karen L. Reckamp
Consulting or Advisory Role - Amgen; ARIAD; Astellas Pharma; AstraZeneca; Boehringer Ingelheim; Calithera Biosciences; Euclises; Exelixis; Genentech; Guardant Health; Loxo; Precision Health Economics; Seagen; Takeda; Tesaro
Research Funding - Abbvie (Inst); ACEA Biosciences (Inst); Adaptimmune (Inst); ARIAD (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); Guardant Health (Inst); Janssen Oncology (Inst); Loxo (Inst); Molecular Partners (Inst); Pfizer (Inst); Seagen (Inst); Xcovery (Inst); Zeno Pharmaceuticals (Inst)
 
D. Ross Camidge
Honoraria - Abbvie; Achilles Therapeutics; Apollomics; Archer; Arrys/Kyn; AstraZeneca; BeyondSpring Pharmaceuticals; bio-thera; Blueprint Medicines; Bristol-Myers Squibb; CBT pharmaceuticals; Daiichi Sankyo; Elevation Oncology; EMD Serono; G1 therapeutics; Hansoh; Helsinn Therapeutics; Hengrui Pharmaceutical; Inivata; Lilly; medtronic; regeneron; Ribon Therapeutics; Roche; takeda
Research Funding - Takeda
 
Huub Jan Kleijn
Employment - Certara Inc; Certara Inc
 
Aziz Ouerdani
Employment - Certara Inc
Consulting or Advisory Role - Certara Inc
Research Funding - Certara Inc
 
Francesco Bellanti
Employment - Certara Inc
Consulting or Advisory Role - Certara Inc
Research Funding - Certara Inc
 
John Maringwa
Employment - Certara Inc
Consulting or Advisory Role - Certara Inc
Research Funding - Certara Inc
 
Michael J. Hanley
Employment - Takeda
 
Shining Wang
Employment - Takeda
Stock and Other Ownership Interests - Sanofi
Travel, Accommodations, Expenses - Takeda
 
Pingkuan Zhang
Employment - Takeda
 
Karthik Venkatakrishnan
Employment - Takeda