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Clinical activity of MCLA-128 (zenocutuzumab), trastuzumab, and vinorelbine in HER2 amplified metastatic breast cancer (MBC) patients (pts) who had progressed on anti-HER2 ADCs. |
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Consulting or Advisory Role - AstraZeneca (Inst); Black Diamond Therapeutics (Inst); Boehringer Ingelheim (Inst); Daiichi Sankyo (Inst); Genentech/Roche (Inst); Lilly (Inst); Mersana (Inst); Novartis (Inst); Pfizer (Inst); Puma Biotechnology (Inst); Silverback Therapeutics (Inst) |
Research Funding - Abbvie (Inst); Acerta Pharma (Inst); Aravive (Inst); ArQule (Inst); Arvinas (Inst); AstraZeneca (Inst); BerGenBio (Inst); Black Diamond Therapeutics (Inst); Boehringer Ingelheim (Inst); Clovis Oncology (Inst); Compugen (Inst); Curis (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); Deciphera (Inst); eFFECTOR Therapeutics (Inst); Eisai (Inst); EMD Serono (Inst); Fochon Pharmaceuticals (Inst); Fujifilm (Inst); G1 Therapeutics (Inst); Genentech/Roche (Inst); H3 Biomedicine (Inst); Harpoon (Inst); Hutchison MediPharma (Inst); Immunomedics (Inst); InventisBio (Inst); Karyopharm Therapeutics (Inst); Leap Therapeutics (Inst); Lilly (Inst); Lycera (Inst); Macrogenics (Inst); MedImmune (Inst); Medivation (Inst); Mersana (Inst); Merus (Inst); Millennium (Inst); Molecular Templates (Inst); Novartis (Inst); Nucana (Inst); OncoMed (Inst); Orinove (Inst); Pfizer (Inst); Puma Biotechnology (Inst); Radius Health (Inst); Regeneron (Inst); Rgenix (Inst); Seagen (Inst); Sermonix Pharmaceuticals (Inst); Silverback Therapeutics (Inst); Stem CentRx (Inst); Sutter Medical Group (Inst); Syndax (Inst); Syros Pharmaceuticals (Inst); Taiho Pharmaceutical (Inst); Takeda (Inst); TapImmune Inc. (Inst); Tesaro (Inst); Torque (Inst); Torque (Inst); Unum Therapeutics (Inst); Verastem (Inst); Zenith Epigenetics (Inst); Zymeworks (Inst) |
Travel, Accommodations, Expenses - Amgen; AstraZeneca; Bayer; Bristol-Myers Squibb; Clovis Oncology; Eisai; EMD Serono; Foundation Medicine; Genentech; Genentech/Roche; Genzyme; Guardant Health; Helsinn Therapeutics; HERON; Lexicon; Lilly; Lilly; Medivation; Merck; Novartis; Pfizer; Roche; Sysmex; Tesaro |
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Consulting or Advisory Role - Ipsen; Lilly; Novartis; Pfizer |
Travel, Accommodations, Expenses - Novartis; Novartis; Pfizer |
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Consulting or Advisory Role - Myriad Genetics; Novartis; Pierre Fabre; Puma Biotechnology |
Research Funding - Merus (Inst); Pfizer (Inst); Puma Biotechnology (Inst) |
Travel, Accommodations, Expenses - AstraZeneca; MSD Oncology; Novartis; Pfizer |
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Research Funding - Abbvie (Inst); AstraZeneca (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Cascadian Therapeutics (Inst); Lilly (Inst); Merus (Inst); MSD (Inst); Nektar (Inst); Novartis (Inst); Roche (Inst); Roche/Genentech (Inst); Sanofi/Aventis (Inst); Seagen (Inst) |
Travel, Accommodations, Expenses - AstraZeneca; Novartis; Pfizer; Roche/Genentech |
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No Relationships to Disclose |
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Travel, Accommodations, Expenses - Pfizer; Roche |
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Consulting or Advisory Role - Amgen; Astellas Pharma; AstraZeneca; Celgene; Daiichi Sankyo; Eisai; GE Healthcare; Genentech; GlaxoSmithKline; Macrogenics; Medscape; Merck Sharp & Dohme; Merus; Mundipharma; Mylan; Novartis; Pfizer; Pierre Fabre; Prime Oncology; Roche; Samsung Bioepis; Sanofi; Seagen; Teva |
Travel, Accommodations, Expenses - AstraZeneca; Pfizer; Roche |
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Research Funding - Seagen (Inst) |
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No Relationships to Disclose |
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No Relationships to Disclose |
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Speakers' Bureau - OncLive |
Research Funding - Boehringer Ingelheim (Inst); Celldex (Inst); Dana Farber Cancer Hospital (Inst); Genentech (Inst); GRAIL (Inst); Immunomedics (Inst); Innocrin Pharma (Inst); Lilly (Inst); Merus NV (Inst); Novartis (Inst); Odonate Therapeutics (Inst); TapImmune Inc. (Inst) |
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Consulting or Advisory Role - AstraZeneca; Lilly; Pfizer |
Speakers' Bureau - Amgen; Amgen; AstraZeneca; Novartis; Pfizer |
Research Funding - Menarini Silicon Biosystems (Inst); Novartis (Inst); Pfizer (Inst); Roche (Inst) |
Patents, Royalties, Other Intellectual Property - MSI and ESR1 detection by ddPCR (patents pending) (Inst) |
Travel, Accommodations, Expenses - Amgen; AstraZeneca; Menarini Silicon Biosystems; Pfizer; Roche |
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Honoraria - Roche; Synthon |
Consulting or Advisory Role - Amcure; Amgen; Boehringer Ingelheim; G1 Therapeutics; Macrogenics; Novartis; Novartis; Radius Health; Roche; Servier |
Travel, Accommodations, Expenses - Amgen; MSD Oncology; Pfizer; Roche Belgium |
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Consulting or Advisory Role - Pierre Fabre; Roche |
Speakers' Bureau - Eisai; Pierre Fabre; Roche |
Research Funding - Roche (Inst); Synthon (Inst) |
Travel, Accommodations, Expenses - Daiichi Sankyo; Pierre Fabre; Roche |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Merus NV |
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Consulting or Advisory Role - AstraZeneca; MSD Oncology; Novartis; Pfizer; Roche; Seagen |
Research Funding - AstraZeneca (Inst); Novartis (Inst); Roche (Inst) |
Travel, Accommodations, Expenses - AstraZeneca; pfizer; Roche |