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Results of a completed phase I study of LAM-002 (apilimod dimesylate), a first-in-class phosphatidylinositol-3-phosphate 5 kinase (PIKfyve) inhibitor, administered as monotherapy or with rituximab or atezolizumab to patients with previously treated follicular lymphoma or other B-cell cancers. |
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Catherine S. Magid Diefenbach |
Stock and Other Ownership Interests - Gilead Sciences |
Consulting or Advisory Role - Bayer; Bristol-Myers Squibb; Celgene; Genentech/Roche; Janssen; Merck; MorphoSys; Seagen |
Research Funding - Bristol-Myers Squibb (Inst); Genentech (Inst); Incyte (Inst); Janssen (Inst); LAM Therapeutics (Inst); MEI Pharma (Inst); Merck (Inst); Millennium (Inst); Roche/Genentech (Inst); Seagen (Inst); Trillium Therapeutics (Inst) |
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Consulting or Advisory Role - Genentech/Roche; Gilead Sciences; Janssen; Seagen |
Research Funding - AI Therapeutics; AstraZeneca; Bristol-Myers Squibb; Genentech/Roche; Hutchison MediPharma; Seagen; Takeda; Unum Therapeutics |
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Research Funding - AI Therapeutics |
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Honoraria - Research to Practice; WebMD |
Research Funding - Affimed Therapeutics (Inst); AI Therapeutics (Inst); Bristol-Myers Squibb (Inst); Pfizer (Inst); Regeneron (Inst); Seagen (Inst); Trillium Therapeutics (Inst) |
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Honoraria - Bayer; Celgene; Gamida Cell; Gilead Sciences; Janssen Oncology; Juno Therapeutics; Novartis; Pfizer; Spectrum Pharmaceuticals; TG Therapeutics |
Research Funding - Celgene; Genentech/Roche; Janssen Biotech; Karus Therapeutics; LAM Therapeutics; TG Therapeutics |
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Consulting or Advisory Role - Abbvie; Alimera Sciences; Alimera Sciences; Bayer; Bristol-Myers Squibb; Celgene; EMD Serono; Genentech; Gilead Sciences; Janssen; Juno Therapeutics; Karyopharm Therapeutics; Kite, a Gilead company; Merck; MorphoSys; Novartis; Verastem |
Research Funding - AI Therapeutics (Inst); Celgene (Inst); Seagen (Inst) |
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Consulting or Advisory Role - Innovent Biologics |
Research Funding - Alexion Pharmaceuticals (Inst); Alexo Therapeutics (Inst); Apexian Pharmaceuticals (Inst); Asana Biosciences (Inst); Ascentage Pharma (Inst); BeiGene (Inst); Cerulean Pharma (Inst); Constellation Pharmaceuticals (Inst); Coordination Therapeutics (Inst); CytomX Therapeutics (Inst); Formation Biologics (Inst); Forty Seven (Inst); Incyte (Inst); InhibRx (Inst); Innovent Biologics (Inst); Jounce Therapeutics (Inst); Livzon (Inst); Loxo (Inst); Macrogenics (Inst); Merck (Inst); Northern Biologics (Inst); Pfizer (Inst); Regeneron (Inst); Symphogen (Inst); TaiRx, Inc. (Inst); Tesaro (Inst) |
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Research Funding - AI Therapeutics |
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Consulting or Advisory Role - Akcea Therapeutics |
Research Funding - AI Therapeutics; Akcea Therapeutics; AstraZeneca |
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Research Funding - Boston Biomedical (Inst); Gilead Sciences (Inst); LAM Therapeutics (Inst); Roche (Inst) |
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Research Funding - AI Therapeutics (Inst) |
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Employment - AI Therapeutics |
Stock and Other Ownership Interests - AI Therapeutics; Alexion Pharmaceuticals; Pfizer |
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No Relationships to Disclose |
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Employment - AI Therapeutics |
Patents, Royalties, Other Intellectual Property - AI Therapeutics |
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Employment - AI Therapeutics |
Stock and Other Ownership Interests - AI Therapeutics; Zenith Epigenetics |
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Employment - Cleveland BioLabs; VelosBio |
Leadership - Cleveland BioLabs; VelosBio |
Stock and Other Ownership Interests - Abbvie; AI Therapeutics; AstraZeneca; Cancer Genetics; Cleveland BioLabs; Epithany; Gilead Sciences; VelosBio |
Consulting or Advisory Role - AI Therapeutics; Incuron |
Patents, Royalties, Other Intellectual Property - Gilead Sciences; PTC Therapeutics; VelosBio |
Travel, Accommodations, Expenses - Cleveland BioLabs; Incuron; VelosBio |
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Employment - AI Therapeutics |
Leadership - AI Therapeutics |
Stock and Other Ownership Interests - AI Therapeutics |
Patents, Royalties, Other Intellectual Property - AI Therapeutics |
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Consulting or Advisory Role - AstraZeneca; BeiGene; Celgene; HERON; Juno Therapeutics; Karyopharm Therapeutics; Seagen; Verastem |
Research Funding - Genentech (Inst); Karyopharm Therapeutics (Inst); LAM Therapeutics (Inst); Regeneron (Inst); Roche/Genentech (Inst) |