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Tucatinib versus placebo added to trastuzumab and capecitabine for patients with previously treated HER2+ metastatic breast cancer with brain metastases (HER2CLIMB). |
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Consulting or Advisory Role - Daiichi Sankyo; Genentech/Roche; Novartis; Puma Biotechnology; Seagen |
Research Funding - Genentech; Merck; Pfizer; Seagen |
Patents, Royalties, Other Intellectual Property - Royalties for chapter in Up-to-Date regarding management of breast cancer brain metastases; Royalties, Jones & Bartlett |
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Honoraria - Daiichi Sankyo; Genentech; Puma Biotechnology; Puma Biotechnology; Seagen |
Consulting or Advisory Role - Daiichi Sankyo; Genentech/Roche; Puma Biotechnology; Puma Biotechnology; Seagen |
Research Funding - Daiichi Sankyo (Inst); EMD Serono (Inst); Genentech/Roche (Inst); Pfizer (Inst); Seagen (Inst) |
Travel, Accommodations, Expenses - Daiichi Sankyo; Genentech; Puma Biotechnology; Puma Biotechnology; Seagen |
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Honoraria - Eisai; Genentech/Roche; IPSEN; Puma Biotechnology; Seagen |
Consulting or Advisory Role - Eisai; Genentech/Roche; Ipsen; Puma Biotechnology; Seagen |
Research Funding - G1 Therapeutics (Inst); Lilly (Inst); Merck (Inst); Nektar (Inst); Puma Biotechnology (Inst); Seagen (Inst); Tesaro (Inst) |
Patents, Royalties, Other Intellectual Property - Jones and Bartlett; Up to Date.com |
Travel, Accommodations, Expenses - Eisai |
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Consulting or Advisory Role - Seagen |
Research Funding - Abbott/AbbVie (Inst); Millennium (Inst); Seagen (Inst) |
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Research Funding - Ambryx (Inst); Amgen (Inst); Arvinas (Inst); Bayer (Inst); Biomarin (Inst); Cascadian Therapeutics (Inst); Daiichi Sankyo (Inst); Dignitana (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); Immunomedics (Inst); Lilly (Inst); Macrogenics (Inst); Merrimack (Inst); Novartis (Inst); OBI Pharma (Inst); Pfizer (Inst); Pieris Pharmaceuticals (Inst); Puma Biotechnology (Inst); Radius Health (Inst); sanofi (Inst); Seagen (Inst) |
Other Relationship - Pfizer; Roche |
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Consulting or Advisory Role - Aduro Biotech (Inst); AstraZeneca/MedImmune (Inst); Bristol-Myers Squibb (Inst); G1 Therapeutics (Inst); Merck Sharp & Dohme (Inst); Novartis (Inst); Pfizer (Inst); Roche/Genentech (Inst); Seagen (Inst) |
Research Funding - Bristol-Myers Squibb (Inst); Lilly (Inst); Merck (Inst); Novartis (Inst); Puma Biotechnology (Inst); Roche/Genentech (Inst); Seagen (Inst) |
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Employment - HCA Healthcare (I) |
Consulting or Advisory Role - Abbvie; Daiichi Sankyo; Eisai |
Research Funding - Astellas Pharma; Genentech/Roche; Lilly |
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Research Funding - AstraZeneca (Inst); Bristol-Myers Squibb (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); Immunomedics (Inst); Lilly (Inst); Merck (Inst); Mersana (Inst); Nektar (Inst); Novartis (Inst); PTC Therapeutics (Inst); Sanofi (Inst); Seagen (Inst); SERVIER (Inst); SignalChem (Inst) |
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Honoraria - Novartis; Roche; Seagen |
Consulting or Advisory Role - AstraZeneca; GlaxoSmithKline; Puma Biotechnology; Roche/Genentech; Seagen |
Research Funding - AstraZeneca (Inst); Bayer (Inst); Boehringer Ingelheim (Inst); Cascadian Therapeutics (Inst); Celldex (Inst); GlaxoSmithKline (Inst); Immunomedics (Inst); Novartis (Inst); Philips Healthcare (Inst); Piqur (Inst); Puma Biotechnology (Inst); Roche/Genentech (Inst); Sanofi (Inst); Seagen (Inst); Zenith Epigenetics (Inst) |
Travel, Accommodations, Expenses - Eisai; GP Pharm; Grunenthal; Novartis; Pierre Fabre; Roche |
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Consulting or Advisory Role - Novartis; Pfizer |
Travel, Accommodations, Expenses - Immunomedics |
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Research Funding - Cascadian Therapeutics (Inst); Genentech (Inst); Seagen (Inst) |
Patents, Royalties, Other Intellectual Property - DAKO - Royalties; NeoMarkers - Royalties |
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Consulting or Advisory Role - AstraZeneca; MSD Oncology; Novartis; Pfizer; Roche; Seagen |
Research Funding - AstraZeneca (Inst); Novartis (Inst); Roche (Inst) |
Travel, Accommodations, Expenses - AstraZeneca; pfizer; Roche |
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Research Funding - Amgen (Inst); Astellas Pharma (Inst); Merck (Inst); Puma Biotechnology (Inst); Seagen (Inst) |
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Honoraria - bioTheranostics; Genentech; Genomic Health; Immunomedics; Lilly; Macrogenics; Novartis; Pfizer; Puma Biotechnology |
Consulting or Advisory Role - bioTheranostics; Genentech; Genomic Health; ImmunogenX; Lilly; Macrogenics; Novartis; Puma Biotechnology |
Research Funding - Cascadian Therapeutics (Inst); Eisai (Inst); Novartis (Inst); Pfizer (Inst); Puma Biotechnology (Inst) |
Travel, Accommodations, Expenses - Genomic Health; Immunomedics; Lilly; Macrogenics; Puma Biotechnology |
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Stock and Other Ownership Interests - Andrew Wardley Limited; Manchester Cancer Academy |
Honoraria - AstraZeneca; Lilly; Novartis; Pfizer; Roche |
Consulting or Advisory Role - Accord Research; AstraZeneca; AstraZeneca; Athenex; Athenex; Coleman Research; Daiichi Sankyo; Gerson Lehrman Group; Guidepoint Global; Lilly; MSD Oncology; NAPP Pharmaceuticals; Novartis; Pfizer; Roche |
Speakers' Bureau - AstraZeneca; Eisai; Lilly; Novartis; Pfizer; Roche |
Research Funding - Most Cancer Pharma (Inst); Novartis (Inst); Pfizer (Inst); Roche (Inst) |
Travel, Accommodations, Expenses - Daiichi Sankyo; Roche |
Other Relationship - MSD Oncology |
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No Relationships to Disclose |
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Research Funding - Immunomedics (Inst); Innocrin Pharma (Inst); Novartis (Inst); Syndax (Inst) |
Patents, Royalties, Other Intellectual Property - Royalty-sharing agreement, investorship interest in licensed IP to startup company, Falcon Therapeutics, that is designing neural stem cell-based therapy for glioblastoma multiforme. (I) |
(OPTIONAL) Uncompensated Relationships - G1 Therapeutics (Inst); Genentech/Roche (Inst); GlaxoSmithKline (Inst); Novartis (Inst); Sanofi (Inst) |
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Stock and Other Ownership Interests - Seagen |
Consulting or Advisory Role - Abbvie (I) |
Research Funding - Abbvie (I); Janssen (I); Takeda (I) |
Travel, Accommodations, Expenses - Seagen |
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Employment - Novartis; Seagen |
Stock and Other Ownership Interests - Seagen |
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Stock and Other Ownership Interests - Verastem |
Honoraria - Genentech/Roche; Genomic Health |
Consulting or Advisory Role - Carrick Therapeutics; G1 Therapeutics; Genomic Health; GlaxoSmithKline; Jounce Therapeutics; Leap Therapeutics; Lilly; Seagen |
Research Funding - Genentech (Inst); Novartis (Inst) |