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TALAPRO-1: Phase II study of talazoparib (TALA) in patients (pts) with DNA damage repair alterations (DDRm) and metastatic castration-resistant prostate cancer (mCRPC) – updated interim analysis (IA). |
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Honoraria - Astellas Pharma; AstraZeneca; BioExcel; Daiichi Sankyo; Genentech/Roche; Janssen Oncology; Menarini Silicon Biosystems; Pfizer; Sanofi; Sierra Oncology |
Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Bayer; BioXCel therapeutics; Boehringer Ingelheim; Celgene; Daiichi Sankyo; Eisai; Genentech/Roche; Genmab; GlaxoSmithKline; Janssen Oncology; Menarini Silicon Biosystems; Merck Serono; Merck Sharp & Dohme; Orion; Pfizer; Sanofi; Sierra Oncology; Taiho Pharmaceutical |
Research Funding - Astex Pharmaceuticals (Inst); AstraZeneca (Inst); Bayer (Inst); Celgene (Inst); CellCentric (Inst); Daiichi Sankyo (Inst); Genentech (Inst); GlaxoSmithKline (Inst); MedImmune (Inst); Medivation (Inst); Merck Serono (Inst); Merck Sharp & Dohme (Inst); Orion (Inst); Sanofi (Inst); Sierra Oncology (Inst); Taiho Pharmaceutical (Inst) |
Patents, Royalties, Other Intellectual Property - Abiraterone Rewards to Inventors (Inst); CHK1 inhibitor (Inst); PARP inhibitors and DNA repair defects (Inst); Targeting of IL23 in prostate cancer (Inst) |
Travel, Accommodations, Expenses - Astellas Pharma; AstraZeneca; Genmab; GlaxoSmithKline; Orion; Qiagen; Sanofi; Taiho Pharmaceutical; Vertex |
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No Relationships to Disclose |
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Honoraria - Astellas Pharma |
Consulting or Advisory Role - AstraZeneca; Bayer; Bayer; Blue Earth Diagnostics; Blue Earth Diagnostics; Carrick Therapeutics; Clovis Oncology; Clovis Oncology; Ferring; Ferring; Hinova Pharmaceuticals; Hinova Pharmaceuticals; Janssen; Merck Sharp & Dohme; Novartis; Pfizer |
Research Funding - Aragon Pharmaceuticals (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Bayer (Inst); Clovis Oncology (Inst); eFFECTOR Therapeutics (Inst); Emergent BioSolutions (Inst); Ferring (Inst); Medivation (Inst); Pfizer (Inst); Roche (Inst) |
Travel, Accommodations, Expenses - Bayer; Blue Earth Diagnostics; Blue Earth Diagnostics; Carrick Therapeutics; Clovis Oncology; Ferring; Hinova Pharmaceuticals; Janssen Oncology; Merck Sharp & Dohme; Novartis; Pfizer |
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Honoraria - Abbvie; Amgen; Astellas Pharma; AstraZeneca; Bayer; Janssen; Sanofi |
Consulting or Advisory Role - Astellas Pharma; AstraZeneca/MedImmune; Bayer; Janssen; Sanofi |
Research Funding - Astellas Pharma (Inst); AstraZeneca (Inst); Bayer (Inst); Bristol-Myers Squibb (Inst); Janssen (Inst); Pfizer (Inst); Sanofi (Inst) |
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Consulting or Advisory Role - Janssen-Cilag |
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Consulting or Advisory Role - Astellas Pharma; Bayer; Janssen; Sanofi |
Research Funding - Astellas Pharma (Inst); Bayer (Inst) |
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Stock and Other Ownership Interests - Pfizer |
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Stock and Other Ownership Interests - Pfizer |
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Stock and Other Ownership Interests - Pfizer |
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Stock and Other Ownership Interests - Pfizer |
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Stock and Other Ownership Interests - Pfizer |
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Honoraria - Astellas Pharma; Bayer; Janssen; Sanofi |
Consulting or Advisory Role - Amgen (Inst); Astellas Pharma; AstraZeneca (Inst); Bayer; Curevac (Inst); ESSA (Inst); Janssen Oncology; Orion; Sanofi |
Travel, Accommodations, Expenses - Amgen; Janssen |