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AMEERA-1: Phase 1/2 study of amcenestrant (SAR439859), an oral selective estrogen receptor (ER) degrader (SERD), with palbociclib (palbo) in postmenopausal women with ER+/ human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (mBC). |
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Consulting or Advisory Role - BMS; Lilly; Novartis; Paige.ai; Sanofi; Sermonix Pharmaceuticals; Totus Medicines |
Research Funding - Daiichi Sankyo (Inst); Lilly (Inst); Novartis (Inst); Paige.ai (Inst); Sanofi (Inst) |
Patents, Royalties, Other Intellectual Property - Patents for (1) targeting mutant ER with ER PROTACS and (2) detecting genomic and histologic alterations in breast cancer using machine learning algorithms. (Inst) |
Travel, Accommodations, Expenses - BMS |
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Stock and Other Ownership Interests - Evolent (I) |
Consulting or Advisory Role - AstraZeneca; Context Therapeutics; Eisai; Genomic Health; Syndax |
Research Funding - Eisai; GTx (Inst); Sanofi (Inst) |
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Consulting or Advisory Role - Lilly (Inst); Novartis (Inst); Pfizer (Inst); Radius Health (Inst); Radius Health (Inst); Roche (Inst); Roche (Inst) |
Travel, Accommodations, Expenses - Lilly (Inst); Pfizer (Inst); Roche (Inst) |
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Consulting or Advisory Role - Bristol-Myers Squibb; Lilly; Pfizer; Roche |
Speakers' Bureau - Bristol-Myers Squibb; Lilly; Pfizer; Roche |
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Consulting or Advisory Role - bioTheranostics; Daiichi Sankyo/Astra Zeneca; Foundation Medicine; Genentech; Genentech/Roche (Inst); Immunomedics; Immunomedics (Inst); Innocrin Pharma (Inst); Merck; Novartis; Novartis (Inst); Pfizer; Pfizer (Inst); Philips Healthcare; Puma Biotechnology; Radius Health; Radius Health (Inst); Sanofi; Spectrum Pharmaceuticals |
Research Funding - AstraZeneca/Daiichi Sankyo (Inst); Genentech (Inst); Immunomedics (Inst); Merck (Inst); Novartis (Inst); Pfizer (Inst); Radius Health (Inst); Sanofi (Inst) |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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Honoraria - GT1; Lilly; Novartis |
Consulting or Advisory Role - Abbvie (Inst); Accord Healthcare (Inst); AstraZeneca/MedImmune (Inst); Daiichi Sankyo Europe GmbH; Lilly (Inst); Menarini; Novartis (Inst); Pfizer; Pierre Fabre (Inst); Sandoz-Novartis (Inst); Sanofi (Inst); Seagen (Inst); SERVIER (Inst) |
Speakers' Bureau - Amgen; Novartis |
Research Funding - Novartis (Inst) |
Travel, Accommodations, Expenses - AstraZeneca; Novartis; Pfizer |
Other Relationship - Roche |