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Evaluation of pharmacodynamic (PD) and biologic activity in a preoperative window-of-opportunity (WOO) study of giredestrant (GDC-9545) in postmenopausal patients (pts) with estrogen receptor-positive, HER2-negative (ER+/HER2–) operable breast cancer (BC). |
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Employment - Genentech; Pfizer (I) |
Stock and Other Ownership Interests - Roche |
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No Relationships to Disclose |
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Honoraria - Lilly; Novartis; Pfizer |
Consulting or Advisory Role - Lilly; Novartis |
Speakers' Bureau - Lilly; Novartis; Pfizer |
Travel, Accommodations, Expenses - Pfizer |
Other Relationship - Roche |
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Begoña Bermejo De Las Heras |
Consulting or Advisory Role - MSD; Roche |
Speakers' Bureau - MSD; Novartis; Pfizer; Roche |
Travel, Accommodations, Expenses - Pfizer; Roche |
Other Relationship - Roche |
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No Relationships to Disclose |
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Other Relationship - Roche |
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Honoraria - AstraZeneca; Bayer; Boehringer Ingelheim; Merck; Novartis; Pfizer; Puma Biotechnology; Roche |
Consulting or Advisory Role - AstraZeneca; Bayer; Boehringer Ingelheim; Merck; Novartis; Pfizer; Puma Biotechnology; Roche |
Research Funding - Astellas Pharma (Inst); AstraZeneca (Inst); Genentech (Inst); Novartis (Inst); Oncogenex (Inst); Roche (Inst) |
Other Relationship - Roche |
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Other Relationship - Roche |
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Honoraria - AstraZeneca; Lilly; Novartis; Pfizer; Roche |
Consulting or Advisory Role - AstraZeneca; Lilly; Novartis; Pfizer; Roche |
Speakers' Bureau - AstraZeneca; Lilly; Novartis; Pfizer; Roche |
Travel, Accommodations, Expenses - Roche |
Other Relationship - Roche |
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Consulting or Advisory Role - Abbvie; ADC Therapeutics; AstraZeneca; BluePrint Medicines; Bristol-Myers Squibb; Genentech; Intellisphere; Jounce therapeutics; Lilly; Novartis; Pfizer; Seagen; Spectrum Pharmaceuticals; Synthon; Taiho Pharmaceutical |
Research Funding - ADC Therapeutics (Inst); Clovis Oncology (Inst); Debiopharm Group (Inst); Genentech (Inst); Immunomedics (Inst); Lilly (Inst); Novartis (Inst); Novita Pharmaceuticals (Inst); Pfizer (Inst); Puma Biotechnology (Inst); Zymeworks (Inst) |
Travel, Accommodations, Expenses - AstraZeneca; Intellisphere; Jounce Therapeutics; Pfizer; Taiho Pharmaceutical |
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No Relationships to Disclose |
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Consulting or Advisory Role - Lilly (Inst); Novartis (Inst); Pfizer (Inst); Roche (Inst) |
Research Funding - Novartis (Inst) |
Patents, Royalties, Other Intellectual Property - Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 |
Travel, Accommodations, Expenses - Lilly |
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Other Relationship - Roche |
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Stock and Other Ownership Interests - Genentech |
Patents, Royalties, Other Intellectual Property - Genentech |
Other Relationship - Roche |
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Stock and Other Ownership Interests - Genentech |
Other Relationship - Roche |
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Stock and Other Ownership Interests - Roche |
Other Relationship - Roche |
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Stock and Other Ownership Interests - Roche/Genentech |
Other Relationship - Roche |
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Employment - Genentech; Merck (I) |
Stock and Other Ownership Interests - Merck (I); Roche |
Patents, Royalties, Other Intellectual Property - Genentech |
Other Relationship - Roche |
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Stock and Other Ownership Interests - Genentech |
Patents, Royalties, Other Intellectual Property - Genentech; Genentech (Inst) |
Other Relationship - Roche |
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Consulting or Advisory Role - bioTheranostics; Daiichi Sankyo/Astra Zeneca; Foundation Medicine; Genentech; Genentech/Roche (Inst); Immunomedics; Immunomedics (Inst); Innocrin Pharma (Inst); Merck; Novartis; Novartis (Inst); Pfizer; Pfizer (Inst); Philips Healthcare; Puma Biotechnology; Radius Health; Radius Health (Inst); Sanofi; Spectrum Pharmaceuticals |
Research Funding - AstraZeneca/Daiichi Sankyo (Inst); Genentech (Inst); Immunomedics (Inst); Merck (Inst); Novartis (Inst); Pfizer (Inst); Radius Health (Inst); Sanofi (Inst) |