The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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First-in-human study of lisaftoclax (APG-2575), a novel BCL-2 inhibitor (BCL-2i), in patients (pts) with relapsed/refractory (R/R) CLL and other hematologic malignancies (HMs).
 
Sikander Ailawadhi
Honoraria - Amgen (Inst); Amgen (Inst); AstraZeneca (Inst); BMS (Inst); Janssen (Inst)
Consulting or Advisory Role - Beigene; Celgene; GlaxoSmithKline; Oncopeptides; Sanofi; Takeda
Research Funding - Amgen (Inst); BMS (Inst); Cellectar (Inst); Janssen Biotech (Inst); MedImmune (Inst); Pharmacyclics (Inst); Phosplatin Therapeutics (Inst); Xencor (Inst)
 
Asher Alban Akmal Chanan-Khan
Stock and Other Ownership Interests - Matthew & Asher Inc.; NanoDev Therapeutics
Honoraria - BeiGene
Research Funding - Ascentage Pharma
Patents, Royalties, Other Intellectual Property - Patent on PSMB9 biomarker
 
Zi Chen
Employment - Ascentage Pharma
Stock and Other Ownership Interests - Ascentage Pharma
 
Bo Huang
Employment - Ascentage Pharma
Stock and Other Ownership Interests - Ascentage Pharma Group
 
Marina Konopleva
Honoraria - Abbvie; Amgen; Amgen; Genentech; KisoJi Biotechnology; Roche; Stemline Therapeutics
Consulting or Advisory Role - AbbVie; Amgen; Forty Seven; Genentech/Roche; Janssen; KisoJi Biotechnology; KisoJi Biotechnology; Roche; Stemline Therapeutics
Research Funding - Abbvie (Inst); Ablynx (Inst); Agios (Inst); Ascentage Pharma (Inst); AstraZeneca (Inst); Calithera Biosciences (Inst); Cellectis (Inst); Genentech (Inst); Lilly (Inst); Roche (Inst); Sanofi (Inst)
Patents, Royalties, Other Intellectual Property - Eli LIlly- Research Funding; Issued/ Licensed; Novartis- PENDING; Reata pharmaceutical - Research Funding- (Issued, Licensed, Royalities); Reata pharmaceutical - Research Funding- (Issued, Licensed, Royalities)
 
Danielle M. Brander
Honoraria - Genentech; TG Therapeutics; Verastem
Consulting or Advisory Role - Abbvie; Genentech/Abbvie; Novartis; Pfizer; Pharmacyclics; TG Therapeutics
Research Funding - Abbvie (Inst); ArQule (Inst); Ascentage Pharma (Inst); AstraZeneca (Inst); AstraZeneca (Inst); BeiGene (Inst); Bristol-Myers Squibb (Inst); DTRM (Inst); Genentech (Inst); LOXO (Inst); MEI Pharma (Inst); Novartis (Inst); Pharmacyclics (Inst); TG Therapeutics (Inst)
Travel, Accommodations, Expenses - Abbvie; Teva; TG Therapeutics
Other Relationship - Novartis
 
David Rizzieri
Honoraria - MorphoSys
Consulting or Advisory Role - Abbvie; ACRO; Agios; Amgen; Arog; Bayer; Celgene; Celltrion/Teva; Chimerix; Gilead Sciences; Incyte; Jazz Pharmaceuticals; Kadmon; Kite, a Gilead Company; MustangBio; Novartis; Pfizer; Pharmacyclics; Sanofi; Seagen; Stemline Therapeutics; UCART
Speakers' Bureau - Gilead Sciences; Seagen; Stemline Therapeutics
Research Funding - Stemline Therapeutics
 
Masa Lasica
No Relationships to Disclose
 
Constantine Si Lun Tam
Honoraria - Abbvie; Beigene; Janssen-Cilag; Novartis; Pharmacyclics
Consulting or Advisory Role - Abbvie; BeiGene; Janssen; Loxo; Roche
Research Funding - Abbvie (Inst); Janssen-Cilag (Inst)
 
Costas K. Yannakou
No Relationships to Disclose
 
H. Miles Prince
No Relationships to Disclose
 
Matthew Steven Davids
Honoraria - Research to Practice
Consulting or Advisory Role - Abbvie; Adaptive Biotechnologies; Ascentage Pharma; AstraZeneca; BeiGene; Bristol-Myers Squibb; Celgene; Genentech; Janssen; Lilly; MEI Pharma; Novartis; Pharmacyclics; Takeda; TG Therapeutics; Verastem
Research Funding - Ascentage Pharma (Inst); AstraZeneca (Inst); Genentech (Inst); MEI Pharma (Inst); Novartis (Inst); Pharmacyclics (Inst); Surface Oncology (Inst); TG Therapeutics (Inst); Verastem (Inst)
Travel, Accommodations, Expenses - Abbvie; BeiGene; Genentech; Janssen; TG Therapeutics
 
Zhicong He
Employment - Ascentage Pharma
 
Ming Lu
Employment - Ascentage Pharma Group
Stock and Other Ownership Interests - Ascentage Pharma Group
 
Mohammad Ahmad
Employment - Ascentage Pharma
Stock and Other Ownership Interests - Ascentage Pharma
 
Mingyu Li
Employment - Ascentage Pharma
Stock and Other Ownership Interests - Bristol-Myers Squibb
 
ZHIYAN LIANG
Employment - Ascentage Pharma
Stock and Other Ownership Interests - Ascentage Pharma Group
 
Boyd Mudenda
Employment - Ascentage Pharma Group
Stock and Other Ownership Interests - Ascentage Pharma Group
 
Dajun Yang
Employment - Ascentage Pharma; Ascentage Pharma (I); HealthQuest Pharma; HealthQuest Pharma (I)
Leadership - Ascentage Pharma; Ascentage Pharma (I); HealthQuest Pharma; HealthQuest Pharma (I)
Stock and Other Ownership Interests - Ascentage Pharma; Ascentage Pharma (I)
Research Funding - Sun Yat-sen University; Sun Yat-sen University (Inst)
Patents, Royalties, Other Intellectual Property - Ascentage Pharma; Ascentage Pharma (I)
Travel, Accommodations, Expenses - Ascentage Pharma; Ascentage Pharma (I); HealthQuest Pharma; HealthQuest Pharma (I)
 
Yifan Zhai
Employment - Ascentage Pharma
Leadership - Ascentage Pharma; Ascentage Pharma (I)
Stock and Other Ownership Interests - Ascentage Pharma; Ascentage Pharma (I)
Research Funding - Ascentage Pharma (Inst)
Patents, Royalties, Other Intellectual Property - Ascentage Pharma; Ascentage Pharma (I); Ascentage Pharma (Inst)