The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Talazoparib (TALA), an oral poly (ADP-ribose) polymerase (PARP) inhibitor for men with metastatic castration-resistant prostate cancer (mCRPC) and DNA damage response (DDR) alterations: Detailed safety analyses from TALAPRO-1 trial.
 
Niven Mehra
Consulting or Advisory Role - Astellas Pharma; Bristol-Myers Squibb; Genzyme; Janssen-Cilag; Merck Sharp & Dohme; Roche
Research Funding - Astellas Pharma; Genentech/Roche; Janssen-Cilag; Pfizer; Sanofi
Travel, Accommodations, Expenses - Astellas Pharma; Bristol-Myers Squibb; MSD Oncology; Roche
 
Karim Fizazi
Honoraria - Astellas Pharma (Inst); Bayer; Janssen (Inst); Sanofi (Inst)
Consulting or Advisory Role - Amgen (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Bayer; Bristol-Myers Squibb; Clovis Oncology; Curevac; ESSA (Inst); Janssen Oncology (Inst); Orion; Sanofi (Inst)
Travel, Accommodations, Expenses - Janssen; MSD
 
Johann S. De Bono
Employment - Institute of Cancer Research
Honoraria - Amgen; Astellas Pharma; Astex Pharmaceuticals; AstraZeneca; Bayer; BioExcel; Boehringer Ingelheim; Celgene; CellCentric; Daiichi Sankyo; Eisai; Genentech/Roche; Genmab; GlaxoSmithKline; Harpoon; Janssen Oncology; Medivation; Menarini Silicon Biosystems; Merck Serono; Merck Sharp & Dohme; Orion; Pfizer; Qiagen; Sanofi; Sierra Oncology; Taiho Pharmaceutical; Terumo; Vertex
Consulting or Advisory Role - Amgen; Astellas Pharma; Astellas Pharma; AstraZeneca; Bayer; BioXCel therapeutics; Boehringer Ingelheim; CellCentric; Daiichi Sankyo; Eisai; Genentech/Roche; Genmab; GlaxoSmithKline; Harpoon; Janssen Oncology; Menarini Silicon Biosystems; Merck Serono; Merck Sharp & Dohme; Orion; Pfizer; Qiagen; Sanofi; Sanofi Aventis GmbH; Sierra Oncology; Taiho Pharmaceutical; Terumo; Vertex
Research Funding - Amgen; Astellas Pharma; Astex Pharmaceuticals; AstraZeneca; Bayer; CellCentric; Daiichi Sankyo; Genentech/Roche; Genmab; GlaxoSmithKline; Harpoon; Janssen; Menarini Silicon Biosystems; Merck Serono; Merck Sharp & Dohme; Orion; Pfizer; Sanofi; Sanofi Aventis GmbH; Sierra Oncology; Taiho Pharmaceutical; Vertex
Patents, Royalties, Other Intellectual Property - Abiraterone Rewards to Inventors (Inst); CHK1 inhibitor (Inst); PARP inhibitors and DNA repair defects (Inst); Targeting of IL23 in prostate cancer (Inst)
Travel, Accommodations, Expenses - Amgen; Astellas Pharma; AstraZeneca; Bayer; BioXCel therapeutics; Boehringer Ingelheim; Cellcentric; Daiichi Sankyo; Eisai; Genentech/Roche; Genmab; GlaxoSmithKline; Harpoon; Janssen; Menarini Silicon Biosystems; Merck Serono; Merck Sharp & Dohme; Orion; Pfizer; Qiagen; Qiagen; Sanofi; Sierra Oncology; Taiho Pharmaceutical; Terumo; Vertex
 
Philippe Barthélémy
Honoraria - Astellas Pharma; BMS; IPSEN; Janssen-Cilag; Merck KGaA; MSD; Pfizer
Consulting or Advisory Role - Amgen; AstraZeneca; BMS; ipsen; Janssen-Cilag; MSD Oncology; Pfizer
Travel, Accommodations, Expenses - Astellas Pharma; BMS; IPSEN; Janssen-Cilag; MSD; Pfizer
 
Tanya B. Dorff
Consulting or Advisory Role - Abbvie; Advanced Accelerator Applications; Bayer; Bristol-Myers Squibb; Dendreon; Exelixis; Janssen Oncology; Noxopharm; Seagen
Speakers' Bureau - Exelixis
Research Funding - Pfizer (Inst)
 
Adam Patrick Stirling
Honoraria - AstraZeneca; Pfizer
 
Jean-Pascal H. Machiels
Consulting or Advisory Role - ALX Oncology; AstraZeneca; Bayer; Boehringer Ingelheim; Bristol-Myers Squibb; CUE Biopharma; Debiopharm Group; Incyte; Innate Pharma; Janssen; Merck Serono; Merck Sharp & Dohme; Nanobiotix; Novartis; Pfizer; Roche
Research Funding - Bayer; Janssen; Novartis; Sanofi
Travel, Accommodations, Expenses - Amgen; Bristol-Myers Squibb; MSD; Pfizer
 
Davide Bimbatti
No Relationships to Disclose
 
Deepak Kilari
Honoraria - Exelixis
Consulting or Advisory Role - Exelixis; Merck Sharp & Dohme; Myovant Sciences; Sanofi
Speakers' Bureau - Astellas Pharma; Exelixis; Genzyme; Genzyme (Inst); Janssen
Research Funding - Astellas Pharma (Inst); Exelixis (Inst); Genentech (Inst)
Travel, Accommodations, Expenses - Bayer; Clovis Oncology; Exelixis; Janssen; Sanofi
 
Herlinde Dumez
Travel, Accommodations, Expenses - Astellas Pharma (Inst); AstraZeneca (Inst); Bayer (Inst); Ipsen (Inst); Janssen Cilag (Inst); MSD (Inst); Novartis (Inst); Pfizer (Inst); Roche (Inst); Sanofi (Inst)
 
Consuelo Buttigliero
Consulting or Advisory Role - Janssen-Cilag
Speakers' Bureau - Ipsen
 
Inge M. van Oort
Consulting or Advisory Role - Astellas Pharma; Bayer; Janssen; MSD/AstraZeneca; Roche; Sanofi
Research Funding - Astellas Pharma (Inst); Bayer (Inst); Janssen (Inst)
 
Elena Castro
Honoraria - Astellas Pharma; AstraZeneca; Bayer; Clovis Oncology; Janssen-Cilag; Pfizer; Roche
Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Bayer; Janssen; Merck; MSD Oncology; Pfizer
Research Funding - AstraZeneca (Inst); Bayer (Inst); Janssen (Inst)
Travel, Accommodations, Expenses - Astellas Pharma; AstraZeneca; Bayer; Janssen; Roche
 
Hsiang-Chun Chen
Employment - Pfizer
Stock and Other Ownership Interests - Pfizer
 
Nicola Di Santo
Employment - Pfizer
Leadership - Large Urology Group Practice Association
Stock and Other Ownership Interests - Pfizer
Consulting or Advisory Role - Amgen; AstraZeneca; Bayer; Dendreon; Ferring; Genentech/Roche; Janssen Scientific Affairs; Medivation/Astellas; Myovant Sciences; Pfizer; Sanofi; Tolmar
 
Liza L DeAnnuntis
Employment - Pfizer
Stock and Other Ownership Interests - Pfizer
 
Cynthia G. Healy
Employment - Pfizer
Stock and Other Ownership Interests - Pfizer
 
Giorgio V. Scagliotti
Honoraria - AstraZeneca; Johnson & Johnson/Janssen; Lilly; MSD Oncology; Pfizer; Roche; Takeda
Consulting or Advisory Role - AstraZeneca; BeiGene; Lilly
Speakers' Bureau - AstraZeneca; beigene; Roche
Travel, Accommodations, Expenses - Bayer