The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
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Safety and activity of single-agent giredestrant (GDC-9545) from a phase Ia/b study in patients (pts) with estrogen receptor-positive (ER+), HER2-negative locally advanced/metastatic breast cancer (LA/mBC).
Komal L. Jhaveri
Consulting or Advisory Role - Abbvie; ADC Therapeutics; AstraZeneca; BluePrint Medicines; Bristol-Myers Squibb; Genentech; Intellisphere; Jounce therapeutics; Lilly; Novartis; Pfizer; Seattle Genetics; Spectrum Pharmaceuticals; Synthon; Taiho Pharmaceutical
Research Funding - ADC Therapeutics (Inst); Clovis Oncology (Inst); Debiopharm Group (Inst); Genentech (Inst); Immunomedics (Inst); Lilly (Inst); Novartis (Inst); Novita Pharmaceuticals (Inst); Pfizer (Inst); Puma Biotechnology (Inst); Zymeworks (Inst)
Travel, Accommodations, Expenses - AstraZeneca; Intellisphere; Jounce Therapeutics; Pfizer; Taiho Pharmaceutical
Valentina Boni
Honoraria - IDEAYA Biosciences; Loxo
Consulting or Advisory Role - Guidepoint Global; OncoArt
Speakers' Bureau - Solti
Research Funding - Abbvie (Inst); Adaptimmune (Inst); Alkermes (Inst); Amgen (Inst); Array BioPharma (Inst); AstraZeneca (Inst); Bayer (Inst); BioNTech AG (Inst); Boehringer Ingelheim (Inst); Boston Biomedical (Inst); Bristol-Myers Squibb (Inst); CytomX Therapeutics (Inst); Genmab (Inst); Incyte (Inst); Janssen (Inst); Kura Oncology (Inst); Lilly (Inst); Loxo (Inst); Menarini (Inst); Merck (Inst); Merus (Inst); Novartis (Inst); Pfizer (Inst); Puma Biotechnology (Inst); Roche/Genentech (Inst); Sanofi (Inst); Seattle Genetics (Inst); Synthon (Inst); Tesaro (Inst); Zenith Epigenetics (Inst)
Travel, Accommodations, Expenses - START
Other Relationship - Roche
Joohyuk Sohn
Research Funding - AstraZeneca (Inst); Bayer (Inst); Daiichi Sankyo (Inst); GlaxoSmithKline (Inst); Lilly (Inst); MSD (Inst); Novartis (Inst); Pfizer (Inst); Roche (Inst)
Other Relationship - Roche
Rafael Villanueva-Vásquez
Consulting or Advisory Role - Novartis
Speakers' Bureau - Lilly; Novartis
Travel, Accommodations, Expenses - Eisai; Lilly; Novartis; Pfizer
Other Relationship - Roche
Aditya Bardia
Consulting or Advisory Role - bioTheranostics; Daiichi Sankyo/Astra Zeneca; Foundation Medicine; Genentech; Genentech/Roche (Inst); Immunomedics; Immunomedics (Inst); Innocrin Pharma (Inst); Merck; Novartis; Novartis (Inst); Pfizer; Pfizer (Inst); Philips; Puma Biotechnology; Radius Health; Radius Health (Inst); Sanofi; Spectrum Pharmaceuticals
Research Funding - AstraZeneca/Daiichi Sankyo (Inst); Genentech (Inst); Immunomedics (Inst); Merck (Inst); Novartis (Inst); Pfizer (Inst); Radius Health (Inst); Sanofi (Inst)
Peter Schmid
Employment - Roche (I)
Honoraria - AstraZeneca; Bayer; Boehringer Ingelheim; Merck; Novartis; Pfizer; Puma Biotechnology; Roche
Consulting or Advisory Role - AstraZeneca; Bayer; Boehringer Ingelheim; Merck; Novartis; Pfizer; Puma Biotechnology; Roche
Research Funding - Astellas Pharma; AstraZeneca; Genentech; Novartis; OncoGenex; Roche
Other Relationship - Roche
Elgene Lim
Consulting or Advisory Role - Lilly Australia (Inst); Novartis Australia (Inst); Pfizer (Inst); Roche (Inst)
Research Funding - Novartis Australia (Inst)
Patents, Royalties, Other Intellectual Property - Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
Travel, Accommodations, Expenses - Lilly Australia
Jaymin M. Patel
Honoraria - Radius Health
Consulting or Advisory Role - Guidepoint Pharmacy
Other Relationship - Roche
Jose Alejandro Perez-Fidalgo
Consulting or Advisory Role - Ability Pharma; Amgen; AstraZeneca; Clovis Oncology; Roche; Tesaro
Speakers' Bureau - AstraZeneca Spain; GlaxoSmithKline; Ipsen; Novartis; Pfizer; PharmaMar; Roche
Patents, Royalties, Other Intellectual Property - Pending patent
Travel, Accommodations, Expenses - AstraZeneca; Pfizer; Roche
Sherene Loi
Consulting or Advisory Role - Aduro Biotech (Inst); AstraZeneca (Inst); BMS (Inst); G1 Therapeutics (Inst); GlaxoSmithKline (Inst); Novartis (Inst); PUMA Biotechnology (Inst); Roche/Genentech (Inst); Seattle Genetics (Inst); Silverback Therapeutics (Inst)
Research Funding - AstraZeneca (Inst); Bristol-Myers Squibb (Inst); Lilly (Inst); Merck (Inst); Nektar (Inst); Novartis (Inst); Puma Biotechnology (Inst); Roche/Genentech (Inst); Seattle Genetics (Inst)
Other Relationship - Roche Medical writing support
Seock-Ah Im
Consulting or Advisory Role - Amgen; AstraZeneca; Daiichi Sankyo; Eisai; GlaxoSmithKline; Hanmi; Lilly; MSD; Novartis; Pfizer; Roche/Genentech
Research Funding - AstraZeneca (Inst); Daewoong Pharmaceutical (Inst); Eisai (Inst); Pfizer (Inst); Roche/Genentech (Inst)
Other Relationship - Roche
Smita Kshirsagar
Employment - PRO Unlimited
Other Relationship - Roche
Mary R. Gates
Employment - Genentech
Stock and Other Ownership Interests - Genentech
Other Relationship - Roche
John Bond
Employment - Genentech
Stock and Other Ownership Interests - Roche/Genentech
Other Relationship - Roche
Jennifer Eng-Wong
Employment - Genentech
Stock and Other Ownership Interests - Roche/Genentech
Travel, Accommodations, Expenses - Roche/Genentech
Ching-Wei Chang
Employment - Genentech
Stock and Other Ownership Interests - Roche
Other Relationship - Roche
Nicholas C. Turner
Consulting or Advisory Role - AstraZeneca; Bristol-Myers Squibb; Lilly; MSD; Novartis; Pfizer; Repare Therapeutics; Roche; Taiho Pharmaceutical; Zeno Pharmaceuticals
Research Funding - AstraZeneca (Inst); Bio-Rad (Inst); Clovis Oncology (Inst); Guardant Health (Inst); Pfizer (Inst); Roche (Inst)
Other Relationship - Roche
Elena Lopez Miranda
Honoraria - AstraZeneca; Novartis; Pfizer; Roche
Consulting or Advisory Role - AstraZeneca; Novartis; Pfizer; Roche
Speakers' Bureau - AstraZeneca; Eisai; Novartis; Roche
Expert Testimony - AstraZeneca; Eisai; Novartis; Roche
Travel, Accommodations, Expenses - Novartis; Roche
Other Relationship - Roche
Laura García-Estévez
Research Funding - Roche (Inst)
Other Relationship - Roche
Meritxell Bellet
Honoraria - Lilly; Novartis; Pfizer
Consulting or Advisory Role - Lilly; Novartis
Speakers' Bureau - Lilly; Novartis; Pfizer
Travel, Accommodations, Expenses - Pfizer
Other Relationship - Roche