The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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A phase 1/2 trial of ORIN1001, a first-in-class IRE1 inhibitor, in patients with advanced solid tumors.
 
Nashat Y. Gabrail
Consulting or Advisory Role - Celgene; Chemiocare
Speakers' Bureau - Janssen Oncology; Janssen Oncology; Janssen Oncology; Karyopharm Therapeutics; Taiho Pharmaceutical; Taiho Pharmaceutical; Tesaro/GSK
Research Funding - Amgen (Inst); Bayer (Inst); Chemiocare (Inst); Chemiocare (Inst); Kartos Therapeutics (Inst); Seagen (Inst)
Travel, Accommodations, Expenses - Oncology Supply
 
Erika P. Hamilton
Consulting or Advisory Role - Arvinas (Inst); AstraZeneca (Inst); Black Diamond Therapeutics (Inst); Boehringer Ingelheim (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); Dantari (Inst); Deciphera (Inst); Eisai (Inst); Genentech/Roche (Inst); H3 Biomedicine (Inst); Lilly (Inst); Merck (Inst); Mersana (Inst); Novartis (Inst); Pfizer (Inst); Puma Biotechnology (Inst); Seagen (Inst); Silverback Therapeutics (Inst)
Research Funding - Abbvie (Inst); Acerta Pharma (Inst); Akeso Biopharma (Inst); Amgen (Inst); ArQule (Inst); Arvinas (Inst); AstraZeneca (Inst); Black Diamond Therapeutics (Inst); Boehringer Ingelheim (Inst); Clovis Oncology (Inst); Compugen (Inst); Curis (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); Dana Farber Cancer Hospital (Inst); Deciphera (Inst); eFFECTOR Therapeutics (Inst); EMD Serono (Inst); Fochon Pharmaceuticals (Inst); Fujifilm (Inst); G1 Therapeutics (Inst); Genentech/Roche (Inst); H3 Biomedicine (Inst); Harpoon (Inst); Hutchison MediPharma (Inst); Immunogen (Inst); Immunomedics (Inst); Infinity Pharmaceuticals (Inst); InventisBio (Inst); Karyopharm Therapeutics (Inst); Leap Therapeutics (Inst); Lilly (Inst); Lycera (Inst); Macrogenics (Inst); MedImmune (Inst); Merck (Inst); Mersana (Inst); Merus (Inst); Millennium (Inst); Molecular Templates (Inst); Novartis (Inst); Nucana (Inst); Olema Pharmaceuticals (Inst); OncoMed (Inst); Onconova Therapeutics (Inst); Orinove (Inst); Pfizer (Inst); PharmaMar (Inst); Plexxikon (Inst); Polyphor (Inst); Puma Biotechnology (Inst); Radius Health (Inst); Regeneron (Inst); Rgenix (Inst); Seagen (Inst); Sermonix Pharmaceuticals (Inst); Shattuck Labs (Inst); Silverback Therapeutics (Inst); Stem CentRx (Inst); Sutro Biopharma (Inst); Syndax (Inst); Syros Pharmaceuticals (Inst); Taiho Pharmaceutical (Inst); Takeda (Inst); TapImmune Inc. (Inst); Tesaro (Inst); Torque (Inst); Torque (Inst); Verastem (Inst); Zenith Epigenetics (Inst); Zymeworks (Inst)
 
Anthony D. Elias
Stock and Other Ownership Interests - Abbott Laboratories; Abbvie; Agilent; Alexion Pharmaceuticals; Align Oncology; Allergan; Amgen; Biogenerix; Bristol-Myers Squibb; Cigna; Exact Sciences; Gilead Sciences; Illumina; Lilly; Merck; Pfizer; United Health Group
Consulting or Advisory Role - Ayala Pharmaceuticals
Research Funding - Astellas Pharma (Inst); BioAtla (Inst); Deciphera (Inst); Genentech (Inst); Infinity Pharmaceuticals (Inst); Karyopharm Therapeutics (Inst); Medivation (Inst); Orinove (Inst); TopAlliance BioSciences Inc (Inst); xencor (Inst)
(OPTIONAL) Uncompensated Relationships - Seiyax
 
Mothaffar F. Rimawi
Consulting or Advisory Role - Daiichi Sankyo; Genentech; Macrogenics; Seagen
Research Funding - Pfizer (Inst)
 
Chao Li
Employment - Fosun Pharma
Stock and Other Ownership Interests - GlaxoSmithKline
 
Maria Margarita Corvez
Employment - Fosun Pharma
 
Wei Li
Employment - Fosun Pharma
 
Ying Feng
Employment - Fosun Pharma
 
Jiao Wei
Employment - Fosun Pharma
 
Stephanie Greene
Employment - Orinove
Stock and Other Ownership Interests - Amgen (I)
Consulting or Advisory Role - NDA Partners
Patents, Royalties, Other Intellectual Property - Orinove
 
John Patterson
Employment - Orinove
Leadership - Orinove
Stock and Other Ownership Interests - Orinove
Patents, Royalties, Other Intellectual Property - Orinove
Travel, Accommodations, Expenses - Orinove
 
Qingping Zeng
Employment - Orinove
Leadership - Orinove
Stock and Other Ownership Interests - Orinove
Honoraria - Orinove
 
Ai-Min Hui
Employment - Fosun Pharma
Leadership - Fosun Pharma
Consulting or Advisory Role - Fuchon; Henlius; Orinove
Travel, Accommodations, Expenses - Fosun Pharma