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Effects of baseline lactate dehydrogenase (LDH), interferon gamma (IFN-g) expression, and tumor mutational burden (TMB) on treatment response to first-line atezolizumab (A) + vemurafenib (V) and cobimetinib (C) in BRAFV600 mutation–positive advanced melanoma. |
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Consulting or Advisory Role - Amgen; AstraZeneca; Bristol-Myers Squibb; MSD; Novartis; Pfizer; Pierre Fabre; Roche; Sanofi |
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Honoraria - Array BioPharma; Iovance Biotherapeutics |
Consulting or Advisory Role - Array BioPharma; Iovance Biotherapeutics; Merck; Regeneron; Roche; Sanofi |
Research Funding - alkermes (Inst); Amgen (Inst); Array BioPharma (Inst); Bristol-Myers Squibb (Inst); Incyte (Inst); Iovance Biotherapeutics (Inst); Kartos Therapeutics (Inst); Merck (Inst); Nektar (Inst); Neon Therapeutics (Inst); OncoSec (Inst); Regeneron (Inst); Replimune (Inst); Roche/Genentech (Inst); Senhwa Biosciences (Inst); Ultimovacs (Inst) |
Travel, Accommodations, Expenses - alkermes; Merck; Neon Therapeutics; Regeneron; Roche/Genentech |
(OPTIONAL) Uncompensated Relationships - Regeneron; Roche/Genentech |
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Stock and Other Ownership Interests - PrimeVax |
Consulting or Advisory Role - 4SC; Alkermes; Array BioPharma; AstraZeneca; Boehringer Ingelheim; Bristol-Myers Squibb; Daiichi Sankyo; Eisai; Idera; Immunocore; Incyte; Italfarmaco; Lunaphore Technologies; MedImmune; Merck Serono; Merck Sharp & Dohme; Nektar; Nouscom; Novartis; OncoSec; Pfizer; Pierre Fabre; Regeneron; Roche/Genentech; Sandoz; Sanofi; Seagen; Sun Pharma; Takis Biotech; Ultimovacs |
Research Funding - Array BioPharma (Inst); Bristol-Myers Squibb (Inst); Roche/Genentech (Inst); Sanofi (Inst) |
Travel, Accommodations, Expenses - Merck Sharp & Dohme |
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Honoraria - BMS; Merck Serono; Merck Serono; MSD; Novartis; Roche; Sanofi |
Consulting or Advisory Role - BMS; Merck Serono; Roche; Sanofi |
Speakers' Bureau - Bristol-Myers Squibb; MSD; Novartis; Roche |
Research Funding - Bristol-Myers Squibb; Lilly; MSD; Novartis; Roche |
Travel, Accommodations, Expenses - Bristol-Myers Squibb; MSD; Roche; Sanofi |
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Honoraria - Amicus Therapeutics; Boehringer Ingelheim; Bristol-Myers Squibb; Merck Sharp & Dohme; Novartis; Roche |
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Consulting or Advisory Role - Bristol-Myers Squibb; MSD Oncology; Novartis; Roche |
Research Funding - Celgene (Inst); Celgene (Inst); Roche (Inst) |
Travel, Accommodations, Expenses - Roche |
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No Relationships to Disclose |
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Leadership - Associated Medical Professionals of New York; Italian Melanoma Intergroup |
Honoraria - Bristol-Myers Squibb; MSD; Novartis; Pierre Fabre; Roche; Sanofi |
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Consulting or Advisory Role - Bristol-Myers Squibb; MSD |
Speakers' Bureau - Bristol-Myers Squibb; MSD; Novartis; Pierre Fabre |
Travel, Accommodations, Expenses - Bristol-Myers Squibb; MSD; Pierre Fabre |
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Stock and Other Ownership Interests - Roche |
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Stock and Other Ownership Interests - Roche |
Travel, Accommodations, Expenses - Genentech |
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Stock and Other Ownership Interests - Roche |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Genentech |
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Honoraria - Almirall Hermal GmbH; Amgen; Bayer; Bristol-Myers Squibb; Immunocore; Merck Serono; Merck Sharp & Dohme; Novartis; Pierre Fabre; Roche/Genentech; Sanofi/Regeneron; Sun Pharma |
Consulting or Advisory Role - 4SC; Almirall Hermal GmbH; Amgen; Bristol-Myers Squibb; Immunocore; Merck Serono; Merck Sharp & Dohme; Novartis; Pierre Fabre; Roche/Genentech; Sanofi; Sun Pharma |
Research Funding - Amgen (Inst); Johnson & Johnson (Inst); Merck Serono (Inst); Novartis (Inst); Pfizer (Inst); Sanofi (Inst); Sun Pharma (Inst) |
Travel, Accommodations, Expenses - Bristol-Myers Squibb; Merck Serono; Pierre Fabre; Roche; Sun Pharma |
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Research Funding - Array BioPharma (Inst); Genentech/Roche (Inst) |