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First-in-human phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of oral GNS561, a palmitoyl-protein thioesterase 1 (PPT1) inhibitor, in patients with primary and secondary liver malignancies. |
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Consulting or Advisory Role - Adaptimmune; Bristol-Myers Squibb; CytomX Therapeutics; Eisai; Exelixis; Imvax; Lilly; Merck; Zymeworks |
Research Funding - Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Calithera Biosciences (Inst); Debiopharm Group (Inst); Incyte (Inst); Lilly (Inst); Novartis (Inst); Pfizer (Inst); Polaris (Inst); Yiviva (Inst); Zymeworks (Inst) |
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Consulting or Advisory Role - Amgen; AstraZeneca; Bayer; Bristol-Myers Squibb; Daiichi Sankyo/Lilly; Daiichi Sankyo/Lilly; Eisai; Genomic Health; Ipsen; LEO Pharma; Lilly; Merck Serono; MSD; Novartis; Pfizer; Roche |
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No Relationships to Disclose |
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No Relationships to Disclose |
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Consulting or Advisory Role - AstraZeneca; Bayer; Eisai; Ipsen; Lilly; MSD; Roche |
Travel, Accommodations, Expenses - AstraZeneca; Bayer; Roche |
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No Relationships to Disclose |
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No Relationships to Disclose |
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Employment - GenoScience Pharma |
Stock and Other Ownership Interests - GenoScience Pharma |
Consulting or Advisory Role - Gilead Sciences |
Travel, Accommodations, Expenses - Abbvie; Gilead Sciences |
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Employment - GenoScience Pharma |
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Employment - GenoScience Pharma |
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Employment - GenoScience Pharma |
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Employment - GenoScience Pharma |
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No Relationships to Disclose |
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Employment - GenoScience Pharma |
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No Relationships to Disclose |
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Consulting or Advisory Role - Agios; AstraZeneca; Autem Medical; Bayer; BeiGene; Berry Genomics; Celgene; CytomX Therapeutics (I); Eisai; Flatiron Health; Genoscience Pharma; Gilead Sciences; Gilead Sciences; Incyte; Ipsen; LAM Therapeutics; Lilly; Loxo (I); Merck Serono; Minapharma; QED Therapeutics; RedHill Biopharma; Roche/Genentech; Silenseed (I); Sillajen; SOBI (I); TheraBionic; twoXAR; Vector Health; Yiviva |
Research Funding - Agios (Inst); AstraZeneca (Inst); Bayer (Inst); Bristol-Myers Squibb (Inst); CASI Pharmaceuticals (Inst); Exelixis (Inst); Incyte (Inst); Polaris (Inst); Puma Biotechnology (Inst); QED Therapeutics (Inst) |
Travel, Accommodations, Expenses - Polaris |