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A multi-modular phase I/II study of UCB6114, a first-in-class, fully human IgG4P anti-Gremlin-1 monoclonal antibody, as monotherapy and in combination with mFOLFOX6 or trifluridine/tipiracil, for patients with advanced gastrointestinal (GI) tumors. |
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Consulting or Advisory Role - AAA HealthCare; Bayer; Eisai; Ipsen; Novartis; Roche; Sirtex Medical; Surface Oncology; UCB (Inst) |
Speakers' Bureau - AstraZeneca; Bayer; Eisai |
Research Funding - UCB (Inst) |
Travel, Accommodations, Expenses - MiNA Therapeutics |
(OPTIONAL) Uncompensated Relationships - Medivir; MINA THERAPEUTICS |
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Employment - Institute of Cancer Research |
Consulting or Advisory Role - Boehringer Ingelheim; Janssen; Phoenix Solutions |
Research Funding - AstraZeneca (Inst); BTG (Inst); Chugai Pharma (Inst); Onyx (Inst); Verastem (Inst) |
Travel, Accommodations, Expenses - Bayer; Sierra Oncology |
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Consulting or Advisory Role - Amphista Therapeutics; Ellipses Pharma; RApport Global; Theolytics; UCB |
Research Funding - Astex Pharmaceuticals (Inst); Incyte (Inst); MSD (Inst); Nucana (Inst); Octimet (Inst); Redx Pharma (Inst); Roche (Inst); Sierra Oncology (Inst); Tesaro (Inst); UCB (Inst) |
Patents, Royalties, Other Intellectual Property - RNA Guardian; RNA Guardian (I) |
Travel, Accommodations, Expenses - Nucana; Tesaro |
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No Relationships to Disclose |
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Honoraria - Ascelia (Inst); AstraZeneca (Inst); Bicycle Therapeutics (Inst); Bristol Myers Squibb (Inst); Eisai (Inst); Merck Sharp & Dohme (Inst); Nucana (Inst); Roche/Genentech (Inst) |
Consulting or Advisory Role - Karus Therapeutics (Inst) |
Speakers' Bureau - AstraZeneca (Inst); Bristol Myers Squibb (Inst); Eisai (Inst); Merck Sharp & Dohme (Inst); Nucana (Inst); Roche/Genentech (Inst); United Medical (Inst) |
Research Funding - Adaptimmune (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Athenex (Inst); Basilea (Inst); Beigene (Inst); Berg Pharma (Inst); Bicycle Therapeutics (Inst); BiolineRx (Inst); Boehringer Ingelheim (Inst); Bristol Myers Squibb (Inst); Celgene (Inst); Clovis Oncology (Inst); CytomX Therapeutics (Inst); Eisai (Inst); GlaxoSmithKline (Inst); Halozyme (Inst); Immunocore (Inst); iOnctura (Inst); Iovance Biotherapeutics (Inst); Janssen (Inst); Johnson & Johnson (Inst); Lilly (Inst); Medivir (Inst); Merck Serono (Inst); Merck Sharp & Dohme (Inst); MiNA Therapeutics (Inst); Modulate Pharma (Inst); Novartis (Inst); Nucana (Inst); Plexxikon (Inst); Roche/Genentech (Inst); Sanofi/Aventis (Inst); Sapience Therapeutics (Inst); Seagen (Inst); Sierra Pharma (Inst); Starpharma (Inst); UCB (Inst); Verastem (Inst); Vertex (Inst) |
Expert Testimony - Medivir (Inst) |
Travel, Accommodations, Expenses - Bristol Myers Squibb; Eisai; Merck Sharp & Dohme; Nucana; Pierre Fabre |
Other Relationship - Genmab (Inst) |
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Honoraria - Amgen (I); AstraZeneca/MedImmune; Bristol-Myers Squibb; Novartis Pharmaceuticals UK Ltd.; Pfizer (I); Tesaro |
Consulting or Advisory Role - Astex Pharmaceuticals; Bayer; Biosceptre; Clovis Oncology; CV6 Therapeutics; Cybrexa Therapeutics; Ellipses Pharma; Karus Therapeutics; Novartis; Octimet; Pierre Fabre; Sanofi/Aventis |
Research Funding - AstraZeneca/MedImmune (Inst) |
Patents, Royalties, Other Intellectual Property - Named on patent of use of PARP inhibitor rucaparib (Inst) |
Travel, Accommodations, Expenses - Bristol-Myers Squibb; MSD Oncology |
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Stock and Other Ownership Interests - UCB |
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Stock and Other Ownership Interests - UCB |
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Stock and Other Ownership Interests - UCB |
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Stock and Other Ownership Interests - GlaxoSmithKline; Lilly; UCB |
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Stock and Other Ownership Interests - UCB |
Patents, Royalties, Other Intellectual Property - UCB |