The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Phase I trial of the RAF/MEK clamp VS-6766 in combination with everolimus using an intermittent schedule with expansion in NSCLC across multiple KRAS variants.
 
Anna Rachel Minchom
Honoraria - Bayer; Chugai Pharma; Faron Pharmaceuticals; Janssen; Novartis Pharmaceuticals UK Ltd.
Consulting or Advisory Role - Genmab; Janssen Oncology; Merck; Takeda
Research Funding - Seagen
Travel, Accommodations, Expenses - Amgen; Loxo
 
Vicky Sanchez Perez
No Relationships to Disclose
 
Cienne Morton
No Relationships to Disclose
 
Thubeena Manickavasagar
No Relationships to Disclose
 
George Nintos
No Relationships to Disclose
 
Julia Elizabeth Lai-Kwon
No Relationships to Disclose
 
Christina Guo
No Relationships to Disclose
 
Nina Tunariu
No Relationships to Disclose
 
Tom Parker
No Relationships to Disclose
 
Toby Prout
No Relationships to Disclose
 
Mona Parmar
No Relationships to Disclose
 
Alison Joanne Turner
No Relationships to Disclose
 
Laura Finneran
Research Funding - AstraZeneca
 
Emma Hall
Research Funding - Accuray (Inst); Alliance Pharma (Inst); AstraZeneca (Inst); Aventis Pharma (Inst); Bayer (Inst); Janssen-Cilag (Inst); Merck Sharpe & Dohme (Inst); Roche (Inst); Varian Medical Systems (Inst)
 
Jonathan A. Pachter
Employment - Verastem
Leadership - Verastem
Stock and Other Ownership Interests - Verastem
Patents, Royalties, Other Intellectual Property - Verastem
 
Louis J. Denis
Employment - Verastem
Leadership - Verastem
Stock and Other Ownership Interests - Verastem
Honoraria - Verastem
Consulting or Advisory Role - Verastem
Travel, Accommodations, Expenses - Verastem
 
James F. Spicer
Stock and Other Ownership Interests - IGEM Therapeutics
Consulting or Advisory Role - Apobec Discovery (Inst); Avacta Life Sciences (Inst); Bristol-Myers Squibb (Inst); Lilly (Inst); Roche (Inst)
Research Funding - Achilles Therapeutics (Inst); BerGenBio (Inst); BluPrint Oncology (Inst); BluPrint Oncology (Inst); Bristol-Myers Squibb (Inst); Genmab (Inst); IO Biotech (Inst); MSD (Inst); Roche (Inst); Starpharma (Inst); Trizell (Inst)
Travel, Accommodations, Expenses - Amgen; Bristol-Myers Squibb; Janssen
 
Udai Banerji
Employment - Institute of Cancer Research
Consulting or Advisory Role - Boehringer Ingelheim; Janssen; PEGASCY
Research Funding - AstraZeneca (Inst); BTG (Inst); Carrick Therapeutics (Inst); Chugai Pharma (Inst); Onyx (Inst); Verastem (Inst)
Travel, Accommodations, Expenses - Bayer; Sierra Oncology