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Longitudinal circulating tumor DNA (ctDNA) whole-exome sequencing (WES) in the phase Ib/II trial of palbociclib and bazedoxifene reveals genomic dynamics and clonal evolution with the acquisition of treatment resistance in hormone receptor-positive, HER2-negative (HR+ HER2-), advanced breast cancer (ABC). |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Ennov1 |
Consulting or Advisory Role - Ennov1; Kojin Therapeutics (I); PACT Pharma |
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No Relationships to Disclose |
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Consulting or Advisory Role - AstraZeneca |
Research Funding - AstraZeneca (Inst) |
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Employment - Freeline Therapeutics (I); PureTech (I) |
Leadership - Freeline Therapeutics (I); PureTech (I) |
Stock and Other Ownership Interests - Freeline Therapeutics (I); PureTech (I) |
Honoraria - AstraZeneca; Genentech/Roche |
Consulting or Advisory Role - AstraZeneca; Bristol-Myers Squibb; Daiichi Sankyo; Genentech/Roche; Macrogenics; Merck; Novartis; Seagen |
Research Funding - Genentech (Inst); Macrogenics (Inst); Pfizer (Inst) |
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Consulting or Advisory Role - Jazz Pharmaceuticals; Novartis; Pfizer; Takeda |
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Consulting or Advisory Role - 4D Pharma; AstraZeneca; Athenex; BeyondSpring Pharmaceuticals; Blueprint Medicines; Bristol-Myers Squibb; Certara Inc; Chugai Pharma; CytomX Therapeutics; Daiichi Sankyo; Eisai; Ellipses Pharma; G1 Therapeutics; Genentech; Immunomedics/Gilead; Infinity Pharmaceuticals; Kyowa Hakko Kirin; Lilly; Merck; Mersana; NanoString Technologies; Nektar; Novartis; Odonate Therapeutics; OncoPep; OncoSec; OncXerna Therapeutics; Paxman; Pfizer; Puma Biotechnology; Reveal Genomics; Samsung Bioepis; Sanofi; Seagen; Zentalis; Zymeworks |
Research Funding - AstraZeneca (Inst); Bristol-Myers Squibb (Inst); Cyclacel (Inst); Eisai (Inst); Exelixis (Inst); Genentech/Roche (Inst); Immunomedics (Inst); Lilly (Inst); Merck (Inst); NanoString Technologies (Inst); Nektar (Inst); Novartis (Inst); Odonate Therapeutics (Inst); Pfizer (Inst); Sanofi (Inst); Seagen (Inst) |
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Leadership - Scorpion Therapeutics |
Stock and Other Ownership Interests - Scorpion Therapeutics |
Consulting or Advisory Role - Scorpion Therapeutics |
Research Funding - IBM; Pharmacyclics |
Patents, Royalties, Other Intellectual Property - Multiple bioinformatics patents |
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No Relationships to Disclose |