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| Complete evaluation of resistance mechanisms to first-line osimertinib requires tissue biopsy. | 
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| Consulting or Advisory Role - Blueprint Medicines; C4 Therapeutics; Cullinan Oncology; Daiichi Sankyo Europe GmbH; Janssen; Jazz Pharmaceuticals; Takeda | 
| Research Funding - Abbvie (Inst); ARIAD/Takeda (Inst); AstraZeneca (Inst); Blueprint Medicines (Inst); Cullinan Oncology (Inst); Daiichi Sankyo Europe GmbH (Inst); GlaxoSmithKline/Tesaro (Inst); Janssen Oncology (Inst); Novartis (Inst); Spectrum Pharmaceuticals (Inst) | 
| (OPTIONAL) Uncompensated Relationships - AstraZeneca/MedImmune | 
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| Consulting or Advisory Role - Genzyme | 
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| No Relationships to Disclose | 
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| No Relationships to Disclose | 
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| No Relationships to Disclose | 
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| No Relationships to Disclose | 
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| No Relationships to Disclose | 
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| Consulting or Advisory Role - Engine Biosciences; Nuvalent, Inc.; TigaTx; Tolremo | 
| Research Funding - Amgen (Inst); Blueprint Medicines (Inst); BridgeBio Pharma (Inst); Bristol-Myers Squibb (Inst); Lilly (Inst); Nuvalent, Inc. (Inst); Pfizer (Inst); Roche/Genentech (Inst); Scorpion Therapeutics (Inst) | 
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| Consulting or Advisory Role - AstraZeneca; Genentech/Roche; Janssen Oncology; Takeda | 
| Research Funding - AstraZeneca (Inst); Boehringer Ingelheim (Inst); Cullinan Oncology (Inst); Daiichi Sankyo/Astra Zeneca (Inst); Delfi Diagnostics (Inst); Genentech (Inst); Johnson & Johnson (Inst); Merck (Inst); Novartis (Inst); Pfizer (Inst) |