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First-in-human (FIH) phase I study of the highly selective phosphoinositide 3-kinase inhibitor delta (PI3Kδ) inhibitor IOA-244 in patients with advanced cancer: Safety, activity, pharmacokinetic (PK), and pharmacodynamic (PD) results. |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Incyte; iOnctura |
Consulting or Advisory Role - Nouscom; Step Pharma |
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Stock and Other Ownership Interests - iOnctura |
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Stock and Other Ownership Interests - iOnctura |
Research Funding - iOnctura |
Patents, Royalties, Other Intellectual Property - I am a named inventor on several patents wholly owned by my employer, iOnctura, as declared in my COI |
Travel, Accommodations, Expenses - iOnctura |
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Stock and Other Ownership Interests - iOnctura |
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Stock and Other Ownership Interests - LabCorp |
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Consulting or Advisory Role - LabCorp |
Speakers' Bureau - LabCorp |
Research Funding - LabCorp |
Travel, Accommodations, Expenses - LabCorp |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Cytodelics |
Consulting or Advisory Role - Health Advances |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Radiomics |
Consulting or Advisory Role - Radiomics |
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No Relationships to Disclose |
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Honoraria - AstraZeneca; Bristol-Myers Squibb; Celgene/Bristol-Myers Squibb; Gilead Sciences; GlaxoSmithKline; Incyte; Janssen Oncology; Merck Sharp & Dohme; Novartis |
Consulting or Advisory Role - ADC Therapeutics; Celgene/Bristol-Myers Squibb; Karyopharm Therapeutics; Novartis; Roche; Sanofi |
Research Funding - ADC Therapeutics (Inst); Roche (Inst); Sanofi (Inst) |
Travel, Accommodations, Expenses - ADC Therapeutics; Janssen; Roche; Takeda |
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Consulting or Advisory Role - ARQULE; Bayer; Bristol-Myers Squibb; Eisai; Gilead Sciences; Incyte; MSD; Pfizer; Sanofi; SERVIER |
Speakers' Bureau - Abbvie; Amgen; ArQule; AstraZeneca; Bayer; BMS; Celgene; Eisai; Gilead Sciences; Lilly; MSD; Novartis; Pfizer; Roche; Sandoz; Servier; Takeda |
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No Relationships to Disclose |
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Honoraria - Ascelia (Inst); AstraZeneca (Inst); Bicycle Therapeutics (Inst); Bristol Myers Squibb (Inst); Eisai (Inst); Medivir (Inst); Merck Sharp & Dohme (Inst); Nucana (Inst); Roche/Genentech (Inst) |
Consulting or Advisory Role - Karus Therapeutics (Inst) |
Speakers' Bureau - AstraZeneca (Inst); Bristol Myers Squibb (Inst); Eisai (Inst); Medivir (Inst); Merck Sharp & Dohme (Inst); Nucana (Inst); Roche/Genentech (Inst); United Medical (Inst) |
Research Funding - Adaptimmune (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Athenex (Inst); Basilea (Inst); Beigene (Inst); Berg Pharma (Inst); Bicycle Therapeutics (Inst); BiolineRx (Inst); Boehringer Ingelheim (Inst); Bristol Myers Squibb (Inst); Celgene (Inst); Clovis Oncology (Inst); CytomX Therapeutics (Inst); Eisai (Inst); GlaxoSmithKline (Inst); Halozyme (Inst); Immunocore (Inst); iOnctura (Inst); Iovance Biotherapeutics (Inst); Janssen (Inst); Johnson & Johnson (Inst); Lilly (Inst); Medivir (Inst); Merck Serono (Inst); Merck Sharp & Dohme (Inst); MiNA Therapeutics (Inst); Modulate Pharma (Inst); Novartis (Inst); Nucana (Inst); Plexxikon (Inst); Roche/Genentech (Inst); Sanofi/Aventis (Inst); Sapience Therapeutics (Inst); Seagen (Inst); Sierra Pharma (Inst); Starpharma (Inst); UCB (Inst); Verastem (Inst); Vertex (Inst) |
Expert Testimony - Medivir (Inst) |
Travel, Accommodations, Expenses - Bristol Myers Squibb; Eisai; Merck Sharp & Dohme; Nucana; Pierre Fabre |
Other Relationship - Genmab (Inst) |
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Stock and Other Ownership Interests - Epigen Therapeutics; Theravance |
Honoraria - Alfasigma; Amgen; AstraZeneca; Bristol-Myers Squibb; Lilly; Merck; MSD; Pierre Fabre; Roche; Sanofi |
Consulting or Advisory Role - Alfasigma; AstraZeneca; Bristol-Myers Squibb; Merck; MSD; Pierre Fabre; Roche |
Patents, Royalties, Other Intellectual Property - DNA Hypomethylating agents for cancer therapy |
Travel, Accommodations, Expenses - Alfasigma; Amgen; AstraZeneca; Bristol-Myers Squibb; Merck; MSD; Pierre Fabre; Roche |