The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Results from a phase 1a/1b study of botensilimab (BOT), a novel innate/adaptive immune activator, plus balstilimab (BAL; anti-PD-1 antibody) in metastatic heavily pretreated microsatellite stable colorectal cancer (MSS CRC).
 
Anthony B. El-Khoueiry
Honoraria - ABL bio; Agenus; AstraZeneca/MedImmune; Bayer; Bristol-Myers Squibb; Eisai; EMD Serono; Exelixis; Gilead Sciences; Merck; QED Therapeutics; Qurient; Roche/Genentech; Senti Biosciences; SERVIER; Tallac Therapeutics
Consulting or Advisory Role - ABL Bio; Agenus; AstraZeneca/MedImmune; Bayer; Bristol-Myers Squibb; Eisai; Exelixis; Gilead Sciences; Merck; Pieris Pharmaceuticals; QED Therapeutics; Qurient; Roche; Senti Biosciences; SERVIER; Tallac Therapeutics
Research Funding - Astex Pharmaceuticals; AstraZeneca; Fulgent Genetics
 
Marwan Fakih
Honoraria - Amgen
Consulting or Advisory Role - Amgen; Bayer; GlaxoSmithKline; Incyte; Mirati Therapeutics; Nouscom; Pfizer; Roche/Genentech; Seagen; Taiho Pharmaceutical
Speakers' Bureau - Guardant Health
Research Funding - Amgen (Inst); Verastem (Inst)
 
Michael S. Gordon
Stock and Other Ownership Interests - BeckonCall; Caremission; WCCT Global
Consulting or Advisory Role - Imaging Endpoints; Morphic Therapeutic; Qualigen Therapeutics; Viracta Therapeutics
Research Funding - AADi (Inst); Abbvie (Inst); Advaxis (Inst); Agenus (Inst); Alpine Immune Sciences (Inst); Amal Therapeutics (Inst); Amgen (Inst); Arcus Biosciences (Inst); Athenex (Inst); Ayala Pharmaceuticals (Inst); Beigene (Inst); BeiGene (Inst); BioEclipse Therapeutics (Inst); BiolineRx (Inst); BiolineRx (Inst); BioNTech (Inst); BioXCel therapeutics (Inst); Black Diamond Therapeutics (Inst); Blueprint Medicines (Inst); Caris Centers of Excellence (Inst); Celgene (Inst); Celldex (Inst); Codiak Biosciences (Inst); Coordination Therapeutics (Inst); Corcept Therapeutics (Inst); Deciphera (Inst); Dracen (Inst); Driver Group (Inst); DynamiCure Biotechnology (Inst); Elevation Oncology (Inst); Endocyte (Inst); Faeth Therapeutics (Inst); FibroGen (Inst); Fore Biotherapeutics (Inst); FORMA Therapeutics (Inst); Fujifilm (Inst); Fujifilm (Inst); Fujifilm (Inst); Fujifilm (Inst); Genentech/Roche (Inst); Genzada Pharmaceuticals (Inst); Genzada Pharmaceuticals (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); HCW Biologics (Inst); Helix BioPharma (Inst); Helix BioPharma (Inst); HiberCell (Inst); I-Mab (Inst); IDEAYA Biosciences (Inst); IgM Biosciences (Inst); IgM Biosciences (Inst); ImaginAb (Inst); ImaginAb (Inst); ImmuneSensor Therapeutics (Inst); ImmuneSensor Therapeutics (Inst); Inanovate (Inst); Incyte (Inst); Inhibrx (Inst); InhibRx (Inst); Intra ImmuSG (Inst); Istari Oncology (Inst); Jubilant Therapeutics (Inst); Lilly/ImClone (Inst); MabVax (Inst); MabVax (Inst); MedImmune (Inst); Merck (Inst); Merck Serono (Inst); Minneamrita Therapeutics (Inst); Molecular Partners (Inst); Nektar (Inst); Nektar (Inst); Nektar (Inst); NiKang Therapeutics (Inst); Nimbus Therapeutics (Inst); Novartis (Inst); Novita Pharmaceuticals (Inst); OncoResponse (Inst); PEEL Therapeutics (Inst); Pfizer (Inst); Pionyr (Inst); Pionyr (Inst); Plexxikon (Inst); Revolution Medicines (Inst); Revolution Medicines (Inst); Riboscience (Inst); Rubius Therapeutics (Inst); Salarius Pharmaceuticals (Inst); Salarius Pharmaceuticals (Inst); Samumed (Inst); Seagen (Inst); Seattle Genetics/Astellas (Inst); Senhwa Biosciences (Inst); Simcha Therapeutics (Inst); Sirnaomics (Inst); Sirnaomics (Inst); Syndax (Inst); Syndax (Inst); Synthorx (Inst); Theseus Pharmaceuticals (Inst); Tolero Pharmaceuticals (Inst); Tolero Pharmaceuticals (Inst); Toray Industries (Inst); TRACON Pharma (Inst); Trishula Therapeutics (Inst); TTC Oncology (Inst); TTC Oncology (Inst); Vedanta Biosciences (Inst); Veru (Inst); Y-mAbs Therapeutics (Inst); Zai Lab (Inst)
Patents, Royalties, Other Intellectual Property - Patient on patient selection for Clinical Trials
 
Apostolia Maria Tsimberidou
Consulting or Advisory Role - Diaccurate; Vincerx Pharma
Research Funding - Agenus (Inst); IMMATICS (Inst); Karus Therapeutics (Inst); Novocure (Inst); OBI Pharma (Inst); Parker Institute for Cancer Immunotherapy (Inst); Tempus (Inst); Tvardi Therapeutics (Inst)
 
Andrea J. Bullock
Consulting or Advisory Role - Exelixis; Geistlich Pharma
 
Breelyn A. Wilky
Consulting or Advisory Role - Adaptimmune; Adcendo; Boehringer Ingelheim; Daiichi Sankyo; Deciphera; Epizyme; Polaris; SpringWorks Therapeutics
Research Funding - Agenus; Exelixis
Travel, Accommodations, Expenses - Adaptimmune; Daiichi Sankyo; Deciphera
 
Jonathan C. Trent
Consulting or Advisory Role - AADi; Agios; Bayer; Blueprint Medicines; Boehringer Ingelheim; C4 Therapeutics; Cogent Medicine; Daiichi Sankyo; Deciphera; Epizyme; Foghorn Therapeutics; SERVIER
 
Kim Allyson Margolin
Honoraria - Lilly
Consulting or Advisory Role - Checkmate Pharmaceuticals; ImaginAb; Iovance Biotherapeutics; Natera; Tentarix Biotherapeutics; Werewolf Therapeutics; Xilio Therapeutics
 
Daruka Mahadevan
Speakers' Bureau - Caris Centers of Excellence; Guardant Health
Other Relationship - Janssen
 
Ani Sarkis Balmanoukian
Speakers' Bureau - AstraZeneca; Bristol-Myers Squibb; Genentech
 
Rachel E. Sanborn
Honoraria - Amgen; AstraZeneca
Consulting or Advisory Role - AstraZeneca; Blueprint Medicines; Daiichi Sankyo/Lilly; EMD Serono; Genentech/Roche; GlaxoSmithKline; Janssen Oncology; Macrogenics; Mirati Therapeutics; Regeneron; Sanofi/Aventis
Research Funding - AstraZeneca; Bristol-Myers Squibb (Inst); MedImmune (Inst); Merck
Travel, Accommodations, Expenses - AstraZeneca
 
Gary K. Schwartz
Stock and Other Ownership Interests - Bionaut Labs; GenCirq; January Therapeutics
Consulting or Advisory Role - AADi; Apexigen; Array BioPharma; Astex Pharmaceuticals; Bionaut Labs; Concarlo; Ellipses Pharma; Epizyme; Gencirq; January Therapeutics; Kirilys Therapeutics; Oncogenuity; OnCusp Therapeutics; PureTech; Sellas Life Sciences; Shanghai Pharma
Research Funding - Adaptimmune (Inst); Astex Pharmaceuticals; Astex Pharmaceuticals (Inst); Calithera Biosciences (Inst); Daiichi Sankyo (Inst); Fortress Biotech (Inst); Incyte (Inst); Karyopharm Therapeutics (Inst); Lilly (Inst); Oxford BioTherapeutics (Inst); SpringWorks Therapeutics (Inst); TopAlliance BioSciences Inc (Inst); TRACON Pharma (Inst)
Patents, Royalties, Other Intellectual Property - Companion diagnostics for CD4 inhibitors (Inst); patent granted to develop a new technology called PNAs for cancer therapy
Travel, Accommodations, Expenses - Array BioPharma; Epizyme; Epizyme; Epizyme
 
Bruno Bockorny
Consulting or Advisory Role - Blueprint Medicines
Research Funding - Nanoview Diagnostics
Travel, Accommodations, Expenses - ERYTECH Pharma
 
Justin C Moser
Honoraria - Caris Life Sciences; Daiichi Sankyo/Lilly; TGen
Consulting or Advisory Role - Adagene; Amunix; Bristol Myers Squibb Foundation; Imaging Endpoints; Thirona Biosciences
Speakers' Bureau - Caris Life Sciences
Research Funding - Alpine Immune Sciences (Inst); Amgen (Inst); BioEclipse Therapeutics (Inst); Fujifilm (Inst); Genentech (Inst); IDEAYA Biosciences (Inst); ImmuneSensor Therapeutics (Inst); Istari Oncology (Inst); Nektar (Inst); Novocure (Inst); Repertoire Immune Medicines (Inst); Rubius Therapeutics (Inst); Simcha Therapeutics (Inst); Synthorx (Inst); Trishula Therapeutics (Inst); University of Arizona (Inst)
Other Relationship - Caris Life Sciences
 
Joseph Elan Grossman
Employment - Agenus
Stock and Other Ownership Interests - Agenus
 
Waldo Ignacio Ortuzar Feliu
Employment - Agenus
Stock and Other Ownership Interests - Agenus
 
Katherine Rosenthal
Employment - Agenus
Stock and Other Ownership Interests - Agenus
 
Steven O'Day
No Relationships to Disclose
 
Heinz-Josef Lenz
Honoraria - Bayer; Boehringer Ingelheim; Fulgent Genetics; G1 THerapeutics; GlaxoSmithKline; Isofol Medical; Jazz Pharmaceuticals; Merck Serono; Oncocyte; Roche
Consulting or Advisory Role - Bayer; BMS; GlaxoSmithKline; Merck Serono; Roche
Travel, Accommodations, Expenses - Bayer; BMS; Merck Serono
 
Benjamin L. Schlechter
No Relationships to Disclose