The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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TACTIVE-U: Phase 1b/2 umbrella study of ARV-471, a proteolysis targeting chimera (PROTAC) estrogen receptor (ER) degrader, combined with other anticancer treatments in ER+ advanced or metastatic breast cancer.
 
Rachel M. Layman
Consulting or Advisory Role - Celcuity; GE Healthcare (I); Lilly; Novartis; Siemens (I)
Research Funding - Accutar Biotech; Celcuity; GlaxoSmithKline (Inst); Lilly (Inst); Novartis (Inst); Pfizer (Inst); Puma Biotechnology (Inst); Zentalis (Inst)
(OPTIONAL) Uncompensated Relationships - Lilly
 
Katarzyna Joanna Jerzak
Honoraria - Amgen; Apobiologix; AstraZeneca; Eisai; Genomic Health; Gilead Sciences; Knight Therapeutics; Lilly; Merck; Myriad Genetics; Novartis; Pfizer; Roche; Seagen
Consulting or Advisory Role - Amgen; Apobiologix; AstraZeneca; Eisai; Genomic Health; Gilead Sciences; Knight Therapeutics; Lilly; Merck; Myriad Genetics; Novartis; Pfizer; Roche; Seagen; Seagen
Research Funding - AstraZeneca; Lilly; Seagen
Patents, Royalties, Other Intellectual Property - I am the lead inventor on a patent for the use of dronedarone and its structural derivatives as cancer therapies.
Other Relationship - Roche
 
John Frederick Hilton
Consulting or Advisory Role - Arvinas; AstraZeneca; Bristol Myers Squibb Foundation; Lilly O.; Merck; Novartis
Research Funding - GlaxoSmithKline; Lilly O.
 
Katherine Clifton
Employment - Zing Health (I)
Stock and Other Ownership Interests - Centene (I); WellCare (I)
Consulting or Advisory Role - bioTheranostics; Pfizer
 
Baha Alkuzweny
Employment - Pfizer
Consulting or Advisory Role - Pfizer
 
Gary Mo
Employment - Metrum Research Group; Pfizer
Stock and Other Ownership Interests - Pfizer
Consulting or Advisory Role - Metrum Research Group
 
Olga Valota
Employment - Pfizer
Stock and Other Ownership Interests - Pfizer
 
Julia Perkins Smith
Employment - Pfizer
Stock and Other Ownership Interests - Pfizer
Patents, Royalties, Other Intellectual Property - Pfizer
 
Sibyl Anderson
Employment - Arvinas
Stock and Other Ownership Interests - Arvinas
 
Cynthia X. Ma
Honoraria - Guardant Health; PlusOne Health
Consulting or Advisory Role - Agendia; AstraZeneca; Athenex; Bayer; Biovica; Gilead Sciences; Lilly; Novartis; Olaris; Pfizer; Sanofi; Seagen; Tempus
Research Funding - Pfizer (Inst); Puma Biotechnology (Inst)
Patents, Royalties, Other Intellectual Property - UpToDate: Authorship - served as a co-author on the subject of endocrine therapy for metastatic breast cancer and receive compensation as an author, less than a few hundred dollars a year. It does not affect my patient care or research.
Travel, Accommodations, Expenses - SABCS; Total Health Conferencing