The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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A phase I/II dose escalation and expansion trial to evaluate safety and preliminary efficacy of BNT141 in patients with claudin-18.2-positive solid tumors.
 
Kyriakos P. Papadopoulos
Consulting or Advisory Role - Basilea; Bicycle Therapeutics; Turning Point Therapeutics
Research Funding - 3D Medicines (Inst); Abbvie (Inst); ADC Therapeutics (Inst); Amgen (Inst); Anheart Therapeutics (Inst); Bayer (Inst); Bicycle Therapeutics (Inst); Biontech (Inst); Calithera Biosciences (Inst); Daiichi Sankyo (Inst); EMD Serono (Inst); F-star (Inst); Incyte (Inst); Jounce Therapeutics (Inst); Kezar Life Sciences (Inst); Lilly (Inst); Linnaeus Therapeutics (Inst); MabSpace Biosciences (Inst); MedImmune (Inst); Merck (Inst); Mersana (Inst); Mirati Therapeutics (Inst); Peloton Therapeutics (Inst); Pfizer (Inst); Regeneron (Inst); Syros Pharmaceuticals (Inst); Tempest Therapeutics (Inst); Treadwell Therapeutics (Inst)
 
Mustapha Tehfe
Honoraria - Bristol-Myers Squibb; Merck; Pfizer; Taiho Pharmaceutical
Consulting or Advisory Role - Bristol-Myers Squibb; Taiho Pharmaceutical
 
Albiruni Ryan Abdul Razak
Consulting or Advisory Role - Adaptimmune; Bayer; GlaxoSmithKline; Inhibrx; Medison
Research Funding - 23 and Me; Abbvie; Adaptimmune; Amgen; Blueprint Medicines; Boehringer Ingelheim; Bristol-Myers Squibb; Daiichi Sankyo; Deciphera; Frontier Therapeutics; GlaxoSmithKline; Iterion Therapeutics; Karyopharm Therapeutics; MedImmune; Merck; Neoleukin Therapeutics; Pfizer; Rain Therapeutics; Roche/Genentech; Symphogen
Expert Testimony - Medison
 
Shubham Pant
Consulting or Advisory Role - Ipsen; Janssen; Novartis; Zymeworks
Research Funding - 4D Pharma (Inst); Arcus Biosciences (Inst); Astellas Pharma (Inst); bionte (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Elicio Therapeutics (Inst); Ipsen (Inst); Janssen (Inst); Lilly (Inst); Mirati Therapeutics (Inst); NGM Biopharmaceuticals (Inst); Novartis (Inst); Pfizer (Inst); Purple Biotech (Inst); Rgenix (Inst); Xencor (Inst); Zymeworks (Inst)
 
Vincent Chung
Consulting or Advisory Role - Perthera
Speakers' Bureau - AstraZeneca; Coherus Biosciences; Ipsen
Research Funding - Merck (Inst)
 
Drew W. Rasco
Research Funding - 23andMe (Inst); Abbvie (Inst); Arcus Biosciences (Inst); Ascentage Pharma (Inst); Astex Pharmaceuticals (Inst); Boehringer Ingelheim (Inst); Bolt Biotherapeutics (Inst); Celgene (Inst); Compugen (Inst); Constellation Pharmaceuticals (Inst); Coordination Therapeutics (Inst); Cullinan Oncology (Inst); Eisai (Inst); GlaxoSmithKline (Inst); Gossamer Bio (Inst); Kronos; Merck (Inst); Molecular Templates; PureTech (Inst); Seven and Eight Biopharmaceuticals (Inst); Surface Oncology (Inst); Takeda (Inst); TD2 (Inst)
 
Rahima Jamal
Consulting or Advisory Role - BMS
Research Funding - alkermes (Inst); Astellas Pharma (Inst); BioNTech SE (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); Iovance Biotherapeutics (Inst); Merck Sharp & Dohme (Inst); Novartis (Inst); Pacylex (Inst); Pfizer (Inst); Surface Oncology (Inst); VelosBio/Merck (Inst)
 
Jason Willis
Honoraria - Cor2Ed
 
Jesús Fuentes Antrás
No Relationships to Disclose
 
Kerstin Brettschneider
Employment - BioNTech SE
Stock and Other Ownership Interests - BioNTech SE
Patents, Royalties, Other Intellectual Property - BioNTech SE (Inst)
 
Alexandra Zamorski
Employment - BioNTech
 
Hayat Bähr-Mahmud
Employment - BioNTech SE
Stock and Other Ownership Interests - BioNTech SE
Patents, Royalties, Other Intellectual Property - BioNTech SE
 
Secil Koseoglu
Employment - BioNTech
Stock and Other Ownership Interests - BioNTech SE; Surface Oncology
Patents, Royalties, Other Intellectual Property - Platelet Diagnostics LLC
Travel, Accommodations, Expenses - BioNTech SE
 
Philip K Chang
Employment - BioNTech
Stock and Other Ownership Interests - BioNTech SE
Travel, Accommodations, Expenses - BioNTech
 
Claudia Lindemann
Employment - BioNTech SE; Hengrui Pharmaceutical (I)
Stock and Other Ownership Interests - BioNTech SE
Patents, Royalties, Other Intellectual Property - BioNTech SE
Travel, Accommodations, Expenses - BioNTech SE
 
Anna Melissa Schlitter
Employment - BioNTech SE
Stock and Other Ownership Interests - Abbvie; Abbvie (I); AstraZeneca; AstraZeneca (I); BioNTech SE; BioNTech SE (I); Merck; Merck (I); Novartis; Novartis (I); Pfizer; Pfizer (I); Roche; Roche (I)
 
Rita Magenheim
Employment - BioNTech SE
 
Leticia De Mattos-Arruda
Employment - BioNTech SE
Stock and Other Ownership Interests - BioNTech SE
 
Özlem Türeci
Employment - BioNTech SE
Leadership - BioNTech SE
Stock and Other Ownership Interests - BioNTech SE
Research Funding - BioNTech SE
Patents, Royalties, Other Intellectual Property - I am inventor of many patents that are exploited by the industry
Travel, Accommodations, Expenses - BioNTech SE
 
Ugur Sahin
Employment - BioNTech SE
Leadership - BioNTech SE
Stock and Other Ownership Interests - BioNTech SE
Research Funding - BioNTech SE
Patents, Royalties, Other Intellectual Property - I am inventor of many patents that are exploited by the industry
Travel, Accommodations, Expenses - BioNTech SE