The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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First-in-human phase 1 study of CC-94676, a first-in-class androgen receptor (AR) ligand-directed degrader (LDD), in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

Dana E.  Rathkopf

Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Bayer; Bristol-Myers Squibb/Celgene; Genentech; Janssen; Myovant Sciences; Novartis; Promontory

Research Funding - AstraZeneca (Inst); Bristol-Myers Squibb/Celgene (Inst); Genentech/Roche (Inst); Janssen Oncology (Inst); Novartis (Inst); Promontory Therapeutics (Inst)

Manish R.  Patel

Leadership - ION Pharma

Honoraria - Janssen Oncology

Consulting or Advisory Role - Accutar Biotech; Daiichi Sankyo/UCB Japan; Olema Pharmaceuticals

Research Funding - Accutar Biotech (Inst); Accutar Biotech (Inst); Acerta Pharma (Inst); Adagene (Inst); ADC Therapeutics (Inst); Agenus (Inst); Aileron Therapeutics (Inst); Allorion Therapeutics (Inst); Artios (Inst); Artios (Inst); Artios (Inst); Artios (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Bayer (Inst); Bicycle Therapeutics (Inst); BioNTech (Inst); BioTheryX (Inst); BioTheryX (Inst); Black Diamond Therapeutics (Inst); Black Diamond Therapeutics (Inst); Blueprint Medicines (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb/Celgene (Inst); Celgene (Inst); CicloMed (Inst); Clovis Oncology (Inst); Compugen (Inst); Compugen (Inst); Conjupro Biotherapeutics (Inst); Cullinan Oncology (Inst); cyteir (Inst); Daiichi Sankyo (Inst); Erasca, Inc (Inst); Evelo Therapeutics (Inst); Genentech/Roche (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); H3 Biomedicine (Inst); Hengrui Therapeutics (Inst); Hotspot Therapeutics (Inst); Hutchison MediPharma (Inst); IgM Biosciences (Inst); IgM Biosciences (Inst); Immune-Onc Therapeutics (Inst); Immunitas (Inst); Immunogen (Inst); Incyte (Inst); Jacobio (Inst); Janssen (Inst); Jazz Pharmaceuticals (Inst); Kineta (Inst); Klus Pharma (Inst); Kymab (Inst); Lilly (Inst); Loxo (Inst); LSK BioPharma (Inst); Lycera (Inst); MabSpace Biosciences (Inst); MabSpace Biosciences (Inst); Macrogenics (Inst); Merck (Inst); Millennium (Inst); Mirati Therapeutics (Inst); Moderna Therapeutics (Inst); NGM Biopharmaceuticals (Inst); NGM Biopharmaceuticals (Inst); NGM Biopharmaceuticals (Inst); Novartis (Inst); Novartis (Inst); Novartis (Inst); nurix (Inst); Nurix (Inst); Olema Oncology (Inst); ORIC Pharmaceuticals (Inst); ORIC Pharmaceuticals (Inst); Pfizer (Inst); Pionyr (Inst); Prelude Therapeutics (Inst); Puretech (Inst); PureTech (Inst); PureTech (Inst); Relay Therapeutics (Inst); Relay Therapeutics (Inst); Revolution Medicines (Inst); Ribon Therapeutics (Inst); Ribon Therapeutics (Inst); Samumed (Inst); Seven and Eight Biopharmaceuticals (Inst); Silicon Therapeutics (Inst); Step Pharma (Inst); Syndax (Inst); Syndax (Inst); Synthorx (Inst); Taiho Pharmaceutical (Inst); TeneoBio (Inst); Tesaro (Inst); TopAlliance BioSciences Inc (Inst); Treadwell Therapeutics (Inst); Treadwell Therapeutics (Inst); Treadwell Therapeutics (Inst); Vigeo Therapeutics (Inst); Xencor (Inst); Zymeworks (Inst)

Atish Dipankar  Choudhury

Employment - LeMaitre Vascular (I)

Honoraria - Aptitude Health; Bayer; Cancer Network; Clinical Care Options; Color Genomics; Great Debates and Updates; Journal of Clinical Pathways/Oncology Learning Network; Lantheus Medical Imaging; OncLive; Pfizer; Physicans' Education Resource; Springer; Targeted Oncology; Wiley

Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Bayer; Bayer; Blackstone; Blue Earth Diagnostics; Janssen Oncology; Lilly; Pfizer; Sanofi/Aventis; Tolmar

Research Funding - Bayer; Janssen (Inst); Pfizer (Inst)

Drew W.  Rasco

Research Funding - 23andMe (Inst); Abbvie (Inst); Adcentrx Therapeutics (Inst); Arcus Biosciences (Inst); Ascentage Pharma (Inst); Astex Pharmaceuticals (Inst); AstraZeneca (Inst); Aulos Bioscience (Inst); Boehringer Ingelheim (Inst); Bolt Biotherapeutics (Inst); Bristol-Myers Squibb/Celgene (Inst); Compugen (Inst); Constellation Pharmaceuticals (Inst); Cullinan Oncology (Inst); Flare Therapeutics (Inst); GlaxoSmithKline (Inst); Kronos (Inst); Merck (Inst); Molecular Templates (Inst); PureTech (Inst); Seven and Eight Biopharmaceuticals (Inst); Surface Oncology (Inst); Takeda (Inst); TD2 (Inst)

Nehal J.  Lakhani

Consulting or Advisory Role - Ikena Oncology; SK Life Sciences

Research Funding - Alexo Therapeutics (Inst); Alkermes (Inst); Alpine Immune Sciences (Inst); Alpine Immune Sciences (Inst); Apexian Pharmaceuticals (Inst); Ascentage Pharma (Inst); Astellas Pharma (Inst); BeiGene (Inst); Biosplice (Inst); Celgene (Inst); Celgene (Inst); Constellation Pharmaceuticals (Inst); Coordination Therapeutics (Inst); CytomX Therapeutics (Inst); Epizyme (Inst); Forty Seven (Inst); Genmab (Inst); Genmab (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); Helsinn Therapeutics (Inst); Ikena Oncology (Inst); Ikena Oncology (Inst); Incyte (Inst); InhibRx (Inst); Innovent Biologics (Inst); Jounce Therapeutics (Inst); KSQ Therapeutics (Inst); LAM Therapeutics (Inst); Lilly (Inst); Livzon (Inst); Loxo (Inst); Macrogenics (Inst); Merck (Inst); Mersana (Inst); Northern Biologics (Inst); Odonate Therapeutics (Inst); Pfizer (Inst); Regeneron (Inst); Repare Therapeutics (Inst); Sapience Therapeutics (Inst); Sapience Therapeutics (Inst); Seagen (Inst); Servier (Inst); Shattuck Labs (Inst); SK Life Sciences (Inst); Symphogen (Inst); Tesaro (Inst); Tizona Therapeutics, Inc. (Inst)

Jessica E.  Hawley

Consulting or Advisory Role - Daiichi Sankyo/Lilly; ImmunityBio

Research Funding - AstraZeneca (Inst); Bristol-Myers Squibb/Celgene (Inst); Crescendo Biologics (Inst); Macrogenics (Inst); Vaccitech (Inst)

Ana  Aparicio

Honoraria - American Cancer Society; Amgen; Astellas Pharma; AstraZeneca; Biosense Webster (I); Boston Scientific (I); Daiichi Sankyo Inc; Janssen Research & Development

Consulting or Advisory Role - American Cancer Society; Amgen; Astellas Pharma; AstraZeneca; Biosense Webster (I); Boston Scientific (I); Daiichi Sankyo Inc.; Janssen Research & Development

Speakers' Bureau - Biosense Webster (I); Boston Scientific (I)

Research Funding - BioSense Webster (I); Boston Scientific (I); Bristol-Myers Squibb (Inst); Hansen Medical (I); Janssen (Inst); Sanofi (Inst)

Patents, Royalties, Other Intellectual Property - Two (I)

Travel, Accommodations, Expenses - Biosense WEbster (I)

Vivek  Narayan

Honoraria - Pfizer

Consulting or Advisory Role - Amgen; AstraZeneca; Exelixis; Janssen Oncology; Merck; Myovant Sciences; Pfizer/EMD Serono; Regeneron

Research Funding - Bristol-Myers Squibb (Inst); Janssen (Inst); Merck (Inst); Pfizer (Inst); Regeneron (Inst); Tmunity Therapeutics, Inc. (Inst)

Sandy  Srinivas

Consulting or Advisory Role - AstraZeneca; Bayer; Bristol-Myers Squibb; Eisai; Janssen Oncology; Merck; Novartis; Seagen

Research Funding - AstraZeneca (Inst); Bayer (Inst); Bristol-Myers Squibb (Inst); Eisai (Inst); Exelixis (Inst); Genentech (Inst); Merck (Inst); Seattle Genetics/Astellas (Inst)

Other Relationship - Pfizer

Karie  Runcie

Consulting or Advisory Role - Johnson & Johnson/Janssen

Hamid  Emamekhoo

Consulting or Advisory Role - AVEO; Cardinal Health; Cardinal Health; Exelixis; Janssen Biotech; Seagen; Seagen

Zachery R  Reichert

Consulting or Advisory Role - AstraZeneca

Research Funding - AstraZeneca (Inst)

Michael Anthony  Carducci

Consulting or Advisory Role - Acrivon Therapeutics; AstraZeneca; Pfizer; Sanofi

Speakers' Bureau - Remedica

Research Funding - Arcus Biosciences (Inst); Celgene/Bristol-Myers Squibb (Inst); Merck (Inst); pfizer (Inst)

Amber L.  Wells

Employment - Bristol Myers Squibb

Stock and Other Ownership Interests  - Bristol-Myers Squibb/Celgene

Can  Liu

Employment - Bristol-Myers Squibb

Stock and Other Ownership Interests  - Amgen; Biogen; Bristol-Myers Squibb; Pfizer

Travel, Accommodations, Expenses - Bristol-Myers Squibb

Raju  Kandimalla

Employment - Bristol-Myers Squibb

Stock and Other Ownership Interests  - Bristol-Myers Squibb

Jiaju  Wu

Employment - Bristol-Myers Squibb

Stock and Other Ownership Interests  - Bristol-Myers Squibb

Marie Huong  Nguyen

Employment - Bristol-Myers Squibb

Stock and Other Ownership Interests  - Bristol-Myers Squibb

Michael  Pourdehnad

Employment - Bristol-Myers Squibb

Stock and Other Ownership Interests  - Bristol-Myers Squibb

Andrew J.  Armstrong

Consulting or Advisory Role - Astellas Scientific and Medical Affairs Inc; AstraZeneca; Bayer; Bristol-Myers Squibb; Epic Sciences; Exelixis; GoodRx; Janssen; Merck; Myovant Sciences; Novartis; Pfizer; ZAlpha

Research Funding - Amgen (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Bayer (Inst); BeiGene (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Constellation Pharmaceuticals (Inst); FORMA Therapeutics (Inst); Gilead Sciences (Inst); Janssen Oncology (Inst); Merck (Inst); Novartis (Inst); Pfizer (Inst); Roche/Genentech (Inst)

Patents, Royalties, Other Intellectual Property - Circulating tumor cell novel capture technology (Inst)

Travel, Accommodations, Expenses - Astellas Scientific and Medical Affairs Inc