The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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A first-in-human phase 1, multicenter, open-label study of CB-012, a next-generation CRISPR-edited allogeneic anti-CLL-1 CAR-T cell therapy for adults with relapsed/refractory acute myeloid leukemia (AMpLify).
 
Naval Guastad Daver
Consulting or Advisory Role - Abbvie; Agios; Amgen; Arog; Astellas Pharma; Bristol-Myers Squibb; Celgene; Daiichi Sankyo; Genentech; Gilead Sciences; Immunogen; Jazz Pharmaceuticals; Kite, a Gilead company; Novartis; Pfizer; SERVIER; Shattuck Labs; Stemline/Menarini; Syndax; Trillium Therapeutics
Research Funding - Abbvie (Inst); Amgen (Inst); Astellas Pharma (Inst); Bristol-Myers Squibb (Inst); Daiichi Sankyo (Inst); FATE Therapeutics (Inst); Genentech (Inst); Gilead Sciences (Inst); Glycomimetics (Inst); Hanmi (Inst); Immunogen (Inst); Kite, a Gilead company (Inst); Novimmune (Inst); Pfizer (Inst); Servier (Inst); Trillium Therapeutics (Inst); Trovagene (Inst)
 
Abhishek Maiti
Research Funding - Celgene (Inst); Lin BioScience (Inst)
 
David Andrew Sallman
Consulting or Advisory Role - Abbvie; Agios; AvenCell; Bristol-Myers Squibb; Dark Blue Therapeutics; Gilead Sciences; Janssen; Jasper Therapeutics; Kite, a Gilead company; Molecular Partners; Nkarta; Novartis; Orbital Therapeutics; Servier; Syndax; Syndax; Syros Pharmaceuticals; Takeda; Zentalis
Speakers' Bureau - Incyte
Research Funding - Aprea Therapeutics (Inst); Jazz Pharmaceuticals
 
Gail J. Roboz
Stock and Other Ownership Interests - OncoPrecision
Consulting or Advisory Role - Abbvie; Amgen; AstraZeneca; Bristol-Myers Squibb; Caribou Biosciences; Celgene; Daiichi Sankyo; Ellipses Pharma; Genoptix; Geron; GlaxoSmithKline; Janssen; Jasper Pharmaceuticals; Jazz Pharmaceuticals; Molecular Partners; Novartis; OncoPrecision; OncoVerity; Pfizer; Rigel; Rochaze; Syndax; Takeda; Telix Pharmaceuticals
Research Funding - Abbvie; Actinium Pharmaceuticals; Aprea Therapeutics; Astex Pharmaceuticals; Bio-Path Holdings, Inc; Bristol-Myers Squibb; Caribou Biosciences; Celgene; Cellectis; Immune-Onc Therapeutics; ImmunoGen; Janssen; Kura Oncology; Novartis
 
Melhem M. Solh
Speakers' Bureau - Amgen; Bristol-Myers Squibb; GlaxoSmithKline; Seagen
Research Funding - Partner therapeutics
 
Filippo Milano
Honoraria - Caribou Biosciences
Consulting or Advisory Role - Medexus Pharmaceuticals
Research Funding - ExCellThera
 
Stephen Anthony Strickland
Consulting or Advisory Role - Abbvie; BerGenBio; Ellipses Pharma; Genentech; Kura Oncology; Nkarta; Novartis; Senti Biosciences; SOBI; Syros Pharmaceuticals
Research Funding - Beam Therapeutics; Caribou Biosciences; Cellectis; Janssen; Kura Oncology; Novartis; Oryzon Genomics; Schrodinger; Sumitomo Pharma Oncology; Syros Pharmaceuticals; Takeda; Vincerx Pharma
 
Alireza Eghtedar
No Relationships to Disclose
 
Steven Brian Kanner
Employment - Caribou Biosciences
Leadership - Caribou Biosciences
Stock and Other Ownership Interests - Caribou Biosciences
Consulting or Advisory Role - Nosis Bio; Specific Biologics
Patents, Royalties, Other Intellectual Property - Arrowhead Pharmaceuticals; Caribou Biosciences; University of Virginia
 
Guy Ledergor
Employment - Caribou Biosciences
Stock and Other Ownership Interests - Caribou Biosciences
 
Donna Marcy
Employment - Caribou Biosciences
Stock and Other Ownership Interests - Caribou Biosciences
Patents, Royalties, Other Intellectual Property - Caribou Biosciences (Inst)
 
Elizabeth Garner
Employment - Caribou Biosciences
Stock and Other Ownership Interests - Caribou Biosciences
Research Funding - Caribou Biosciences
Patents, Royalties, Other Intellectual Property - Caribou Biosciences
Travel, Accommodations, Expenses - Caribou Biosciences
 
Brian J. Francica
Employment - Caribou Biosciences
Stock and Other Ownership Interests - Caribou Biosciences
Research Funding - Caribou Biosciences
 
McKay Shaw
Employment - Caribou Biosciences
Patents, Royalties, Other Intellectual Property - Caribou Biosciences (Inst)
 
Kalin Bird
Employment - Caribou Biosciences; Gamida Cell
Stock and Other Ownership Interests - Caribou Biosciences; Gamida Cell
 
Jennifer Rattan
Employment - Caribou Biosciences; Fate Therapeutics
Stock and Other Ownership Interests - Amgen; Caribou Biosciences; Fate Therapeutics
 
Enrique Zudaire
Employment - Caribou Biosciences
Stock and Other Ownership Interests - Caribou Biosciences
Patents, Royalties, Other Intellectual Property - Caribou Biosciences
 
Socorro Portella
Employment - Caribou Biosciences, Inc
Stock and Other Ownership Interests - Caribou BioSciences, Inc; Novartis
 
Pankit Vachhani
Honoraria - Abbvie; Amgen; Blueprint Medicines; Cogent Biosciences; CTI BioPharma Corp; Daiichi Sankyo; Genentech; GlaxoSmithKline; Incyte; Karyopharm Therapeutics; Lava Therapeutics; MorphoSys; Novartis; Pfizer; SERVIER; SOBI; Stemline Therapeutics
Consulting or Advisory Role - Abbvie; Amgen; Blueprint Medicines; Cogent Biosciences; CTI BioPharma Corp; Daiichi Sankyo; Genentech; GlaxoSmithKline; Incyte; Karyopharm Therapeutics; Lava Therapeutics; MorphoSys; Novartis; Pfizer; SERVIER; SOBI; Stemline Therapeutics
Speakers' Bureau - Blueprint Medicines; CTI BioPharma Corp; Incyte
Research Funding - Abbvie; Amgen; Blueprint Medicines; Cogent Biosciences; CTI BioPharma Corp; Daiichi Sankyo; Genentech; GlaxoSmithKline; Incyte; Karyopharm Therapeutics; Lava Therapeutics; MorphoSys; Novartis; Pfizer; SERVIER; SOBI; Stemline Therapeutics
 
Jae H. Park
Stock and Other Ownership Interests - Curocel
Honoraria - OncLive
Consulting or Advisory Role - AffyImmune Therapeutics; Allogene Therapeutics; Amgen; Artiva; Autolus; Be Biopharma; BeiGene; Bright Pharmaceutical Services; Caribou Biosciences; Galapagos NV; In8Bio; Kite, a Gilead Company; Medpace; Minerva Biotechnologies; Pfizer; SERVIER; SOBI; Takeda
Research Funding - Autolus (Inst); Fate Therapeutics (Inst); Genentech (Inst); Incyte (Inst); SERVIER (Inst); Takeda (Inst)