The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Avutometinib/defactinib and gemcitabine/nab-paclitaxel combination in first-line metastatic pancreatic ductal adenocarcinoma: Initial safety and efficacy of phase 1b/2 study (RAMP 205).
 
Kian-Huat Lim
Honoraria - CURIS
Patents, Royalties, Other Intellectual Property - Hold patent for targeting MK2 as a therapeutic strategy in pancreatic cancer.
 
Kristen Renee Spencer
Honoraria - American Cancer Society
Consulting or Advisory Role - AstraZeneca; AstraZeneca; Caris Life Sciences; Exelixis; TriSalus Life Sciences
Research Funding - Winn CDA
Travel, Accommodations, Expenses - ASCO; Cholangiocarcinoma Foundation
 
Rachael A Safyan
Honoraria - Curio Science; Guardant Health
Consulting or Advisory Role - Guardant Health
Research Funding - Exelixis (Inst); Replimune (Inst); Verastem (Inst)
 
Vincent J. Picozzi
Stock and Other Ownership Interests - Amgen; Cigna; Iovance Biotherapeutics; Johnson & Johnson; McKesson; Thermo Fisher Scientific
Consulting or Advisory Role - TriSalus Life Sciences
Research Funding - Abbvie; Amal Therapeutics; Astellas Pharma; FibroGen; Ipsen; NovoCure
 
Anna M. Varghese
Consulting or Advisory Role - AstraZeneca (I); Lilly (I); PAIGE (I); Roche (I)
Research Funding - BioMed Valley Discoveries; Bristol-Myers Squibb; Illumina (I); Lilly; Silenseed; Verastem
Travel, Accommodations, Expenses - Roche (I)
 
Despina Siolas
Consulting or Advisory Role - Ciox Health; Zephyr AI
Speakers' Bureau - Natera
 
Kimberly Perez
Consulting or Advisory Role - Celgene; Eisai; Helsinn Therapeutics/QED Therapeutics; Lantheus Medical Imaging
 
Sheena Clift
Employment - Verastem
Stock and Other Ownership Interests - Verastem
 
Louis J. Denis
Employment - Verastem
Leadership - Verastem
Stock and Other Ownership Interests - Verastem
Honoraria - Verastem
Consulting or Advisory Role - Verastem
Travel, Accommodations, Expenses - Verastem
 
Vijeta Bhambhani
Employment - Sirtex Medical; Verastem
Stock and Other Ownership Interests - Fractyl
Travel, Accommodations, Expenses - Sirtex Medical; Verastem
 
Jonathan A. Pachter
Employment - Verastem
Leadership - Verastem
Stock and Other Ownership Interests - Verastem
Travel, Accommodations, Expenses - Verastem
 
Philippe Pultar
Employment - Verastem; Zentalis
Stock and Other Ownership Interests - Biomarin; Vertex; Zentalis
Consulting or Advisory Role - Verastem; Z-Alpha
Patents, Royalties, Other Intellectual Property - Zentalis
 
Manuel Hidalgo
Leadership - BMS
Stock and Other Ownership Interests - Champions Oncology; InxMed; Nelum Corp.
Honoraria - Champions Oncology; InxMed; MiNK Therapeutics; Oncomatrix
Consulting or Advisory Role - Fibrogen; InxMed; KAHR Medical; MiNK Therapeutics; Oncomatrix
Research Funding - Ranok Therapeutics; TopAl
Patents, Royalties, Other Intellectual Property - Royalties from Khar Medical for IP in cell therapy; Royalties from Myriad for PALB2 patent
Travel, Accommodations, Expenses - Agenus