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An open-label, phase 1, multicenter study to evaluate the safety and preliminary anti-tumor activity of NT-112 in human leukocyte antigen-C*08:02–positive adult patients with unresectable, advanced, and/or metastatic solid tumors that are positive for the KRAS G12D mutation. |
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Research Funding - Astellas Pharma (Inst); Constellation Pharmaceuticals (Inst); NCI (Inst); Prelude Therapeutics (Inst); Revolution Medicines (Inst); Simcere (Inst); Tango Therapeutics (Inst); VITRAC Therapeutics (Inst) |
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Honoraria - Castle Biosciences (I) |
Consulting or Advisory Role - Arcus Biosciences (Inst); AstraZeneca (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); Elevation Oncology (Inst); EMD Serono (Inst); Ipsen (Inst); Jazz Pharmaceuticals (Inst); Pfizer (Inst); Seagen (Inst) |
Research Funding - 1200 Pharma (Inst); Actuate Therapeutics (Inst); Agenus (Inst); Arcus Biosciences (Inst); Astellas Pharma (Inst); BeiGene (Inst); BioNTech (Inst); Bristol-Myers Squibb (Inst); Codiak Biosciences (Inst); Compass Therapeutics (Inst); CytomX Therapeutics (Inst); Eisai (Inst); Elevation Oncology (Inst); Exelixis (Inst); Gilead Sciences (Inst); HiberCell (Inst); Immune-Onc Therapeutics (Inst); IMPAC Medical Systems (Inst); Leap Therapeutics (Inst); Novartis (Inst); OncXerna Therapeutics (Inst); Panbela Therapeutics (Inst); Revolution Medicines (Inst); SQZ Biotechnology (Inst); Surface Oncology (Inst); Tachyon Therapeutics (Inst); Translational Genomics Research Institute (Inst); TransThera Sciences (Nanjing), Inc. (Inst); ZielBio (Inst) |
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Consulting or Advisory Role - Ipsen; Legend Biotech |
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Stock and Other Ownership Interests - Actym Therapeutics; Rafael Pharmaceuticals |
Consulting or Advisory Role - Astellas Pharma; Corcept Therapeutics; Exelixis; Gilead Sciences; Istari; Notch Therapeutics; Regenacy Pharmaceuticals; Tempus |
Research Funding - A2 Biotherapeutics (Inst); Amgen (Inst); ARMO BioSciences (Inst); Astellas Pharma (Inst); Bold Therapeutics (Inst); Camurus (Inst); CG Pharmaceuticals (Inst); Crinetics Pharmaceuticals (Inst); Exelixis (Inst); Gilead Sciences (Inst); Gritstone Bio (Inst); Lilly (Inst); Lyell Immunopharma (Inst); Merck (Inst); Mirati Therapeutics (Inst); NGM Biopharmaceuticals (Inst); Tesaro/GSK (Inst); Tizona Therapeutics, Inc. (Inst); Tizona Therapeutics, Inc. (Inst) |
Travel, Accommodations, Expenses - Amgen |
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Employment - Day One Biopharmaceuticals (I) |
Stock and Other Ownership Interests - Actinium Pharmaceuticals |
Honoraria - Array BioPharma; Cardinal Health; Curio Science |
Consulting or Advisory Role - AADi; Advanced Accelerator Applications; Amgen; Array BioPharma; Astellas Pharma; AstraZeneca; Bayer; Bristol Myers Squibb; Eisai; EMD Serono; EMD Serono; Exelixis; Exelixis; Exelixis; Hutchison MediPharma; Incyte; Ipsen; Jazz Pharmaceuticals; Lilly; Mirati Therapeutics; Novartis; Pfizer; QED Therapeutics; Seagen; SERVIER; Stromatis Pharma; Takeda |
Speakers' Bureau - Ideo Oncology |
Research Funding - AstraZeneca (Inst); Bayer (Inst); BioNTech SE (Inst); bristol myers squibb (Inst); Buzzard Pharmaceuticals; Camurus (Inst); Camurus (Inst); Deciphera (Inst); Exelixis (Inst); G1 Therapeutics (Inst); Gilead Sciences (Inst); Gritstone Bio (Inst); Hutchison MediPharma (Inst); incyte (Inst); Innovative Cellular Therapeutics Co (Inst); Inspirna (Inst); Ipsen (Inst); ITM Oncologics (Inst); Lilly (Inst); Merck (Inst); Novartis (Inst); Nucana (Inst); Regenxbio (Inst); Relay Therapeutics (Inst); Seagen (Inst); Sotio (Inst); Taiho Pharmaceutical (Inst); Tempus (Inst); TransThera Biosciences (Inst); Zentalis (Inst) |
Travel, Accommodations, Expenses - AADi; Camurus; Mirati Therapeutics; Nucana; Pfizer |
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Employment - Walgreens (I) |
Patents, Royalties, Other Intellectual Property - Compositions and Methods for the Treatment of Pancreatic Cancer |
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No Relationships to Disclose |
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Consulting or Advisory Role - AstraZeneca; Bristol-Myers Squibb; CDR-Life; Merck; VIR Biotechnology |
Research Funding - AstraZeneca; Bristol-Myers Squibb; Incyte |
Travel, Accommodations, Expenses - Bristol-Myers Squibb |
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Research Funding - Cornerstone Pharmaceuticals (Inst); OneCell Diagnostics India (Inst) |
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Stock and Other Ownership Interests - Aprea Therapeutics; Merus NV; Moderna Therapeutics; Zymeworks |
Research Funding - Astellas Pharma (Inst); Chungchun Intellicrown (Inst); Exelixis (Inst); IMPAC Medical Systems (Inst); Merck (Inst); Poseida (Inst); Sanofi (Inst); Synermore (Inst); Xencor (Inst) |
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Stock and Other Ownership Interests - Johnson & Johnson/Janssen |
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Honoraria - ASCO; Cholangiocarcinoma Foundation; cholangiocarcinoma summit; Colon Cancer Alliance; Curio Science; oklahoma society of clinical oncology; OncLive/MJH Life Sciences; saint joseph hospital Chicago |
Consulting or Advisory Role - Catalyst Pharmaceuticals; Guardant Health; KLJ Associates; Pfizer; Pfizer; Triptych Health Partners |
Research Funding - Astellas Pharma (Inst); BMS (Inst); Clovis Oncology (Inst); Daiichi Sankyo (Inst); Gossamer Bio (Inst); Gritstone Bio (Inst); Hutchison MediPharma (Inst); Macrogenics (Inst); Merck (Inst); Oncologie (Inst); Pfizer (Inst); Seattle Genetics/Astellas (Inst); Takeda (Inst); TP Therapeutics (Inst); verastem (Inst) |
Travel, Accommodations, Expenses - colon cancer alliance; Takeda |
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Stock and Other Ownership Interests - Artiva |
Consulting or Advisory Role - Artiva |
Travel, Accommodations, Expenses - Artiva; Artiva |
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Employment - Neogene Therapeutics |
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Employment - Neogene Therapeutics, Inc. – An AstraZeneca Group company; Sorrento Therapeutics |
Stock and Other Ownership Interests - Sorrento Therapeutics |
Travel, Accommodations, Expenses - Neogene Therapeutics, Inc. – An AstraZeneca Group company; Sorrento Therapeutics |
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Employment - Neogene Therapeutics |
Stock and Other Ownership Interests - Neogene Therapeutics |
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No Relationships to Disclose |
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Employment - Neogene Therapeutics |
Leadership - Neogene Therapeutics |
Stock and Other Ownership Interests - Allogene Therapeutics; Cellectis; Century Therapeutics; Kite, a Gilead company; Neogene Therapeutics |
Patents, Royalties, Other Intellectual Property - Patents resulting from work at Kite Pharma and Kite, a Gilead company |
Travel, Accommodations, Expenses - Neogene Therapeutics |
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Employment - Crispr Therapeutics; Neogene Therapeutics |
Stock and Other Ownership Interests - Crispr Therapeutics; Neogene Therapeutics |
Patents, Royalties, Other Intellectual Property - Crispr Therapeutics |
Travel, Accommodations, Expenses - Crispr Therapeutics; Neogene Therapeutics |
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Consulting or Advisory Role - Bayer; BMS; Eisai; Merck; Mirati Therapeutics; Pfizer; Roche/Genentech; Taiho Pharmaceutical |
Research Funding - Agenus (Inst); Roche/Genentech (Inst); Verastem (Inst) |