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pionERA Breast Cancer (BC): Phase III study of first-line (1L) giredestrant vs. fulvestrant, both combined with a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i), in patients (pts) with estrogen receptor-positive (ER+), HER2– locally advanced/metastatic BC (LA/mBC) with resistance to prior adjuvant (adj) endocrine therapy (ET). |
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Employment - EQRx (I); GRAIL (I) |
Stock and Other Ownership Interests - EQRx (I); GRAIL (I) |
Consulting or Advisory Role - 4D Pharma; AstraZeneca; Cullinan Oncology; Cullinan Oncology; Daiichi Sankyo/Astra Zeneca; eFFECTOR Therapeutics; Genentech/Roche; immunomedics; Lilly; Menarini Silicon Biosystems; Merck; mersana; Myovant Sciences; Novartis; Oncosec; Prelude Therapeutics; Puma Biotechnology; RayzeBio; RayzeBio; Seagen; Takeda |
Research Funding - Ascentage Pharma (Inst); AstraZeneca (Inst); Daichi Sankyo (Inst); Genentech/Roche (Inst); Lilly (Inst); Novartis (Inst); Seagen (Inst) |
Other Relationship - Genentech; Immunomedics |
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Consulting or Advisory Role - AstraZeneca; Carrick Therapeutics; Lilly; Novartis; Pfizer |
Research Funding - Lilly; Pfizer |
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Consulting or Advisory Role - Lilly; Novartis; Pfizer |
Speakers' Bureau - Lilly; Novartis; Pfizer |
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Honoraria - Agendia; AstraZeneca; BionTech (Inst); Cepheid (Inst); Daiichi Sankyo; Eisai; Gilead Sciences; Hexal; Lilly; Merck Sharp & Dohme; Novartis; Pfizer; Pierre Fabre; Roche; Seagen |
Consulting or Advisory Role - Agendia; AstraZeneca; Daiichi Sankyo; Eisai; Gilead Sciences; Hexal; Lilly; Merck Sharp & Dohme; Novartis; Pfizer; Pierre Fabre; Roche; Seagen |
Research Funding - BioNTech (Inst); Cepheid (Inst); Novartis (Inst); Roche |
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Consulting or Advisory Role - AstraZeneca; Lilly; MSD Oncology; Novartis; Pfizer; Roche |
Speakers' Bureau - AstraZeneca; GlaxoSmithKline; MSD Oncology; Novartis |
Research Funding - AstraZeneca; BMS GmbH & Co. KG; Janssen Oncology; Lilly; MSD Oncology; Novartis; Roche |
Travel, Accommodations, Expenses - AstraZeneca; Gador; GlaxoSmithKline; Novartis; Raffo |
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Consulting or Advisory Role - AstraZeneca; AstraZeneca; Bixink; Celgene; Daiichi Sankyo/Astra Zeneca; Eisai; Eisai; Everest Medicine; Merck; MSD; Novartis; Novartis; Pfizer; Roche; Takeda |
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Other Relationship - Support for third-party writing assistance for this abstract, furnished by Kalina Boytcheva, MSc, of Nucleus Global, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland. |
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Stock and Other Ownership Interests - Roche |
Other Relationship - Support for third-party writing assistance for this abstract, furnished by Kalina Boytcheva, MSc, of Nucleus Global, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland. |
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Honoraria - AstraZeneca; Daiichi Sankyo/UCB Japan; Eisai; EuroPharma; Lilly; Merck Sharp & Dohme; Novartis; Pfizer; Roche |
Consulting or Advisory Role - Lilly; Novartis; Pfizer; Roche |
Research Funding - AstraZeneca (Inst); Merck Sharp & Dohme (Inst); Novartis (Inst) |
Travel, Accommodations, Expenses - Novartis |
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Employment - Genentech/Roche |
Stock and Other Ownership Interests - Biosplice (I) |
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Consulting or Advisory Role - AstraZeneca; Bristol Myers Squibb; Eli Lilly & Co.; Merck Sharp & Dohme; Novartis; Pfizer; Repare Therapeutics; F. Hoffmann-La Roche; Taiho Pharmaceutical; Zeno Pharmaceuticals |
Research Funding - AstraZeneca (Inst); Bio-Rad (Inst); Clovis Oncology (Inst); Guardant Health (Inst); Inivata (Inst); InVitae (Inst); Natera, Inc. (Inst); Personalis (Inst); Pfizer (Inst); F. Hoffmann-La Roche (Inst) (Inst) |
Other Relationship - Support for third-party writing assistance for this abstract, furnished by Kalina Boytcheva, MSc, of Nucleus Global, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland |
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Stock and Other Ownership Interests - Roche |
Other Relationship - Support for third-party writing assistance for this abstract, furnished by Kalina Boytcheva, MSc, of Nucleus Global, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland. |
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No Relationships to Disclose |
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Consulting or Advisory Role - Advisory board (self): Lilly; Advisory board or speaker (compensated to the hospital): AstraZeneca, Daiichi Sankyo, Roche, Lilly, Pfizer, Owkin, Novartis, Guardant Health, N-Power Medicine, Servier, Gilead, Boston Pharmaceutics (Inst) |
Research Funding - AstraZeneca, Daiichi Sankyo, Roche, Lilly, Pfizer, Owkin, Novartis, Guardant Health (Inst) |
Other Relationship - Support for third-party writing assistance for this abstract, furnished by Kalina Boytcheva, MSc, of Nucleus Global, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland. |