The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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First-in-human study (FIH) of FS222, a next-generation tetravalent PD-L1/CD137 bispecific antibody: Safety, pharmacodynamics (PD), and antitumor activity in patients (pts) with advanced solid tumors including PD-1 refractory melanoma.
 
Elena Garralda
Employment - Next Oncology
Stock and Other Ownership Interests - 1TRIALSP
Consulting or Advisory Role - Anaveon; Boehringer Ingelheim; Ellipses Pharma; F-Star Therapeutics; Hengrui Therapeutics; Incyte; Janssen; MAB Discovery; Medscape; Roche; Sanofi; Seagen; Thermo Fisher Scientific
Speakers' Bureau - MSD; Novartis; Roche; Seagen; Thermo Fisher Scientific
Research Funding - AstraZeneca/MedImmune (Inst); BeiGene (Inst); Janssen (Inst); Novartis (Inst); Roche (Inst); Taiho Oncology (Inst); Thermo Fisher Scientific (Inst)
Other Relationship - Adaptimmune (Inst); Affimed Therapeutics (Inst); Amgen (Inst); Anaveon (Inst); AstraZeneca (Inst); Bicycle Therapeutics (Inst); Bioinvent (Inst); BioNTech (Inst); Boehringer Ingelheim (Inst); Catalym (Inst); Cyclacel (Inst); CytomX Therapeutics (Inst); Cytovation (Inst); F-Star Beta Limited (Inst); F. Hoffmann LaRoche (Inst); Genentech (Inst); Genmab (Inst); HiFiBiO Therapeutics (Inst); Hutchison MediPharma (Inst); Imcheck Therapeutics (Inst); Immunocore (Inst); Incyte (Inst); Janssen-Cilag SA (Inst); MedImmune (Inst); Merck KGaA (Inst); Novartis (Inst); Peptomyc (Inst); Pfizer (Inst); Relay Therapeutics (Inst); Replimune (Inst); Ribon Therapeutics (Inst); Roche (Inst); Ryvu Therapeutics (Inst); Seagen (Inst); SERVIER (Inst); Sotio (Inst); SQZ Biotech (Inst); Symphogen (Inst); T-Knife (Inst); Taiho Pharmaceutical (Inst)
 
Arjun Oberoi
No Relationships to Disclose
 
Guillermo de Velasco
Honoraria - Astellas Pharma; BMS; Ipsen; Pfizer
Consulting or Advisory Role - Astellas Medivation; Bayer; Bristol-Myers Squibb; Ipsen; Merck; MSD; Novartis; Pfizer; Pierre Fabre; Pierre Fabre; Roche
Research Funding - Ipsen
Travel, Accommodations, Expenses - BMS; BMS; Roche
 
Iván Victoria
No Relationships to Disclose
 
David Pesantez
No Relationships to Disclose
 
Inaki Eguren Santamaría
No Relationships to Disclose
 
Victor Moreno
Employment - START
Consulting or Advisory Role - Abbvie; Affimed Therapeutics; AstraZeneca; Basilea; Bayer; BMS; Janssen Oncology; Merck; Roche
Speakers' Bureau - Bayer; Pierre Fabre
Research Funding - Abbvie (Inst); ACEA Biosciences (Inst); Adaptimmune (Inst); ADC Therapeutics (Inst); Amgen (Inst); Ascendis Pharma (Inst); AstraZeneca (Inst); Bayer (Inst); BeiGene (Inst); Bicycle Therapeutics (Inst); Bioinvent (Inst); Biomea Fusion (Inst); Boehringer Ingelheim (Inst); Bristol-Myers Squibb (Inst); C4 Therapeutics (Inst); Celgene (Inst); Constellation Pharmaceuticals (Inst); Crescendo Bioscience (Inst); Cullinan Oncology (Inst); E-therapeutics (Inst); Eisai (Inst); F-Star Biotechnology (Inst); Genmab (Inst); GlaxoSmithKline (Inst); Grey Wolf Therapeutics (Inst); hemavant (Inst); HiFiBiO Therapeutics (Inst); Janssen (Inst); Kinnate Biopharma (Inst); Menarini (Inst); Merck (Inst); MonTa Biosciences (Inst); Nanobiotix (Inst); Novartis (Inst); Pfizer (Inst); PharmaMar (Inst); PsiOxus Therapeutics (Inst); Puma Biotechnology (Inst); Regeneron (Inst); Revolution Medicines (Inst); RigonTEC (Inst); Roche (Inst); Sanofi (Inst); Sierra Oncology (Inst); Synthon (Inst); Taiho Pharmaceutical (Inst); Takeda (Inst); Tesaro (Inst); Transgene (Inst)
Expert Testimony - Medscape/Bayer; Nanobiotix
Travel, Accommodations, Expenses - Sanofi/Regeneron
Other Relationship - BMS
 
Valentina Boni
Employment - Hospical Quiron Salud; Next Oncology
Leadership - Next Oncology (Inst)
Stock and Other Ownership Interests - 1TRIALSP
Honoraria - Loxo, IDEAYA Biosciences, Puma Biotechnology, Amunix, Guidepoint Global, MSD, Janssen, EMD Serono
Consulting or Advisory Role - OnoArt, Guidepoint Global, Janssen, Lilly, Nanobiotix, Novartis, EMD Serono,
Speakers' Bureau - Solti, Lilly, Tactics, MSD
Research Funding - Array BioPharma, Boehringer, Biontech, Boston Biomedical (Inst); Incyte, Abbvie, Zenith Epigenetics, Genmab, Astrazeneca, Seagen, Adaptaimmune, Alkermes, Amgen (Inst); Roche Genentech, BMS, Menarini, Synthon, Janssen, Merck, Lilly, Merus, Pfizer, Bayer (Inst); SAnofi, Seagen, Loxo, Novartis, CytomX Therapeutics, Puma Biotechnology, Kura Oncology, Tesaro (Inst)
Travel, Accommodations, Expenses - START, Bayer
 
Andres Cervantes
Consulting or Advisory Role - Amgen (Inst); Foundation Medicine (Inst); Merck Serono (Inst); Roche (Inst); Transgene (Inst)
Research Funding - Actuate Therapeutics (Inst); Adaptimmune (Inst); Amcure (Inst); Amgen (Inst); Astellas Pharma (Inst); AstraZeneca Spain (Inst); Bayer (Inst); BeiGene (Inst); BMSi (Inst); FibroGen (Inst); Genentech (Inst); Lilly (Inst); MedImmune (Inst); Merck Serono (Inst); MSD (Inst); Natera (Inst); Novartis (Inst); SERVIER (Inst); Sierra Oncology (Inst); Takeda (Inst)
Other Relationship - Annals of Oncology; Cancer Treatment Reviews; ESMO Open
 
Valentina Gambardella
Consulting or Advisory Role - Boehringer Ingelheim
Research Funding - Amcure (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Bayer (Inst); BeiGene (Inst); Bristol-Myers Squibb (Inst); FibroGen (Inst); Genentech (Inst); Lilly (Inst); MedImmune (Inst); Merck Serono (Inst); MSD (Inst); Natera (Inst); Novartis (Inst); Roche (Inst); SERVIER (Inst); Sierra Oncology (Inst); Takeda (Inst)
Travel, Accommodations, Expenses - Boehringer Ingelheim
 
Tudor-Eliade Ciuleanu
Consulting or Advisory Role - A&D Pharma; Amgen; Astellas Pharma; AstraZeneca; Boehringer Ingelheim; Bristol-Myers Squibb; Janssen; Lilly; Merck Serono; Merck Sharp & Dohme; Novartis; Pfizer; Roche; Sanofi; SERVIER
Travel, Accommodations, Expenses - A&D Pharma; Amgen; Astellas Pharma; AstraZeneca; Boehringer Ingelheim; Bristol-Myers Squibb; Ipsen; Janssen; Lilly; Merck; MSD; Novartis; Pfizer; Roche/Genentech; Sanofi; Servier
 
Milana Bergamino Sirvén
Consulting or Advisory Role - AstraZeneca; Pfizer
Speakers' Bureau - AstraZeneca; Eisai; Novartis; Novartis
Patents, Royalties, Other Intellectual Property - Patent filled with the Institute of Cancer Research on the discrovery of new molecular subgroups in ER+/HER2+ Breast Cancer
 
Delvys Rodriguez-Abreu
Consulting or Advisory Role - AstraZeneca Spain; Bristol-Myers Squibb; MSD; Novartis; Roche
Speakers' Bureau - Bristol-Myers Squibb; MSD; Roche
Travel, Accommodations, Expenses - MSD; Roche
 
Guzman Alonso
No Relationships to Disclose
 
Laurentia Minea Gales
Honoraria - Actavis, Angelini, Amgen, AstraZeneca, Astellas, BMS, Boehringer, Bayer, Ipsen, Johnson and Johnson, MagnaPharma, Merck, MSD, Novartis, Pfizer, Roche, Sanofi, Sandoz, Servier
Consulting or Advisory Role - Actavis, Angelini, Amgen, AstraZeneca, Astellas, BMS, Boehringer, Bayer, Ipsen, Johnson and Johnson, MagnaPharma, Merck, MSD, Novartis, Pfizer, Roche, Sanofi, Sandoz, Servier
Speakers' Bureau - Actavis, Angelini, Amgen, AstraZeneca, Astellas, BMS, Boehringer, Bayer, Ipsen, Johnson and Johnson, MagnaPharma, Merck, MSD, Novartis, Pfizer, Roche, Sanofi, Sandoz, Servier
Travel, Accommodations, Expenses - MSD, Sanofi, AstraZeneca
 
Daniel Jones
No Relationships to Disclose
 
Abhay Patki
No Relationships to Disclose
 
Ignacio Melero
Honoraria - PharmaMar
Consulting or Advisory Role - Alligator Bioscience; Amunix; AstraZeneca/MedImmune; BiolineRx; Boston Pharmaceuticals; Bright Peak Therapeutics; Bristol-Myers Squibb; Catalym; Curon Biopharmaceutical; Dompé farmaceutici; EMD Serono; F-star; Genmab; Genmab; GlaxoSmithKline; Gossamer Bio; Hookipa Pharma; ImmuneSensor Therapeutics; Merus; Moderna Therapeutics; Monopteros Therapeutics; MSD; Noxxon Pharma; Numab; Pieris Pharmaceuticals; Roche/Genentech; Sanofi; SERVIER; Shattuck Labs
Research Funding - Alligator Bioscience; AstraZeneca; Bioncotech; Bristol-Myers Squibb; Roche/Genentech
Travel, Accommodations, Expenses - Bristol-Myers Squibb; Incyte; MSD; Roche/Genentech