The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Phase 1 trial of mevrometostat (PF-06821497), a potent and selective inhibitor of enhancer of zeste homolog 2 (EZH2), in castration-resistant prostate cancer (CRPC).
 
Michael Thomas Schweizer
Consulting or Advisory Role - AstraZeneca; FibroGen; Janssen; Pfizer; Sanofi
Research Funding - Ambrx (Inst); AstraZeneca (Inst); Bristol-Myers Squibb (Inst); Epigenetix (Inst); Immunomedics (Inst); Incyte (Inst); Janssen (Inst); Lilly (Inst); Merck (Inst); Novartis (Inst); Pfizer (Inst); Roche (Inst); SignalOne Bio (Inst); Tmunity Therapeutics, Inc. (Inst); Xencor (Inst); Zenith Epigenetics (Inst)
 
Konstantin Penkov
Consulting or Advisory Role - Nektar
Research Funding - AstraZeneca/MedImmune (Inst); Merck Sharp & Dohme (Inst); Nektar (Inst); Pfizer (Inst); Regeneron (Inst); Roche (Inst)
 
Atish Dipankar Choudhury
Employment - LeMaitre Vascular (I)
Honoraria - Aptitude Health; Bayer; Cancer Network; Clinical Care Options; Color Genomics; Great Debates and Updates; Journal of Clinical Pathways/Oncology Learning Network; Lantheus Medical Imaging; OncLive; Pfizer; Physicans' Education Resource; Springer; Targeted Oncology; Wiley
Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Bayer; Bayer; Blackstone; Blue Earth Diagnostics; Janssen Oncology; Lilly; Pfizer; Sanofi/Aventis; Tolmar
Research Funding - Bayer; Janssen (Inst); Lilly (Inst); Pfizer (Inst)
 
Emiliano Calvo
Employment - HM Hospitales; START
Leadership - BeiGene; European Organisation for Research and Treatment of Cancer (EORTC); Merus NV; Novartis; PharmaMar; Sanofi; START
Stock and Other Ownership Interests - Oncoart Associated; START
Honoraria - HM Hospitales
Consulting or Advisory Role - Adcendo; Amunix; Anaveon; AstraZeneca/MedImmune; Bristol-Myers Squibb; Chugai Pharma; Diaccurate; Elevation Oncology; Ellipses Pharma; Genmab; Janssen-Cilag; MonTa Biosciences; MSD Oncology; Nanobiotix; Nouscom; Novartis; OncoDNA; PharmaMar; Roche/Genentech; Servier; Syneos Health; T-Knife; TargImmune Therapeutics
Research Funding - START
Other Relationship - CRIS Cancer Foundation; Foundation PharmaMar; Investigational Therapeutics in Oncological Sciences
 
Richard C. Frank
No Relationships to Disclose
 
Li Liu
Employment - Pfizer
Stock and Other Ownership Interests - Bayer; Pfizer
Patents, Royalties, Other Intellectual Property - patent pending; Pfizer patent pending
Travel, Accommodations, Expenses - Pfizer
 
Rajendar K. Mittapalli
Employment - Pfizer
Stock and Other Ownership Interests - Pfizer
 
Jessica Tougias
Employment - Pfizer; Syneos Health
Stock and Other Ownership Interests - Pfizer
Consulting or Advisory Role - Endo Health Solutions; Pfizer
Research Funding - Pfizer; Syneos Health
Travel, Accommodations, Expenses - Pfizer
 
Claudia Andreu-Vieyra
Employment - Pfizer
Stock and Other Ownership Interests - JJ Innovative Medicine; Pfizer
Travel, Accommodations, Expenses - JJ Innovative Medicine; Pfizer
 
Timothy Geoffrey Bowler
Employment - Dyno Therapeutics (I); Ivericbio (I); Pfizer; Regenxbio (I); Volastra Therapeutics
Stock and Other Ownership Interests - Regenxbio (I)
Travel, Accommodations, Expenses - Regeneron
 
Neelesh Soman
Employment - Pfizer
Stock and Other Ownership Interests - Pfizer
Travel, Accommodations, Expenses - Pfizer
 
Benjamin Garmezy
Research Funding - Abbvie (Inst); Abbvie (Inst); Accutar Biotech (Inst); Arcus Biosciences (Inst); Arcus Biosciences (Inst); Arcus Biosciences (Inst); AstraZeneca (Inst); AVEO (Inst); crispr therapeutics (Inst); Envision Pharma Group (Inst); Exelixis (Inst); Genentech (Inst); Harbour BioMed (Inst); IDEAYA Biosciences (Inst); Janssen Oncology (Inst); Janux Therapeutics (Inst); Jubilant Therapeutics (Inst); Kineta (Inst); Kineta (Inst); Kinnate Biopharma (Inst); Loxo (Inst); Loxo/Lilly (Inst); MiNK Therapeutics (Inst); Nuvation Bio (Inst); ProfoundBio (Inst); Roche/Genentech (Inst); Teon Therapeutics (Inst); Tmunity Therapeutics, Inc. (Inst); Xencor (Inst); Xencor (Inst); Zenshine (Inst); Zenshine (Inst)
(OPTIONAL) Uncompensated Relationships - Abbvie (Inst); Amgen (Inst); Arcus Biosciences (Inst); Arvinas (Inst); AVEO (Inst); Bayer (Inst); Eisai (Inst); Exelixis (Inst); Janssen (Inst); Merck (Inst); Novartis (Inst); Pfizer (Inst); Sanofi (Inst); Seagen (Inst)