I-SPY2 Endocrine Optimization Pilot (EOP): Neoadjuvant amcenestrant +/- abemaciclib +/- letrozole in molecularly selected patients (pts) with HR+ HER2- stage 2/3 breast cancer (BC).

Amy Jo  Chien

Research Funding - Amgen (Inst); Merck (Inst); Pfizer (Inst); Puma Biotechnology (Inst); Seagen (Inst)

Patents, Royalties, Other Intellectual Property - Pending Patent Application for “COMBINATION INCLUDING A CPG-C TYPE OLIGONUCLEOTIDE AND A PD-1 ANTAGONIST FOR TREATING BREAST CANCER”

Rita A.  Mukhtar

No Relationships to Disclose

Karthik  Giridhar

Consulting or Advisory Role - AstraZeneca/Daiichi Sankyo (Inst); Exact Sciences (Inst); Gilead Sciences (Inst); Lilly (Inst); MJH Live Events (Inst); MJH Live Events (Inst); NeoGenomics Laboratories (Inst); Puma Biotechnology (Inst); Tersera (Inst)

Research Funding - Guardant Health (Inst); Pfizer (Inst)

Travel, Accommodations, Expenses - GRAIL; QuantumLeap Health

Olufunmilayo I.  Olopade

Employment - CancerIQ (I)

Leadership - CancerIQ

Stock and Other Ownership Interests  - 54gene; CancerIQ; HealthWell Solutions; Tempus

Consulting or Advisory Role - Tempus

Research Funding - Color Genomics (Inst); Roche/Genentech (Inst)

(OPTIONAL) Uncompensated Relationships - ACS; Susan G. Komen for the Cure

Kevin  Kalinsky

Employment - EQRx (I); GRAIL (I)

Stock and Other Ownership Interests  - EQRx (I); GRAIL (I)

Consulting or Advisory Role - 4D Pharma; AstraZeneca; Cullinan Oncology; Cullinan Oncology; Daiichi Sankyo/Astra Zeneca; eFFECTOR Therapeutics; Genentech/Roche; immunomedics; Lilly; Menarini Silicon Biosystems; Merck; mersana; Myovant Sciences; Novartis; Oncosec; Prelude Therapeutics; Puma Biotechnology; RayzeBio; RayzeBio; Seagen; Takeda

Research Funding - Ascentage Pharma (Inst); AstraZeneca (Inst); Daichi Sankyo (Inst); Genentech/Roche (Inst); Lilly (Inst); Novartis (Inst); Seagen (Inst)

Other Relationship - Genentech; Immunomedics

Christos  Vaklavas

Employment - Flatiron Health (I)

Honoraria - Cardinal Health; Daiichi Sankyo/Astra Zeneca; Daiichi Sankyo/Astra Zeneca; Gilead Sciences; Guidepoint Global; Novartis; Pfizer; Pfizer; Seagen

Consulting or Advisory Role - AstraZeneca; Daiichi Sankyo; Gilead Sciences

Research Funding - AstraZeneca (Inst); AstraZeneca/Daiichi Sankyo (Inst); Genentech (Inst); H3 Biomedicine (Inst); Incyte (Inst); Innocrin Pharma (Inst); Novartis (Inst); Pfizer (Inst); Pharmacyclics (Inst); Roche (Inst); Seagen (Inst); TRACON Pharma (Inst); Zymeworks (Inst)

Other Relationship - Daiichi Sankyo; Puma Biotechnology; Takeda

(OPTIONAL) Uncompensated Relationships - Genentech

Anthony D.  Elias

Stock and Other Ownership Interests  - Abbott Laboratories; Abbvie; Agilent; Alexion Pharmaceuticals; Align Oncology; Allergan; Amgen; Biogenerix; Bristol-Myers Squibb; Cigna; Exact Sciences; Gilead Sciences; Illumina; Lilly; Merck; Pfizer; United Health Group

Research Funding - Astellas Pharma (Inst); ImmuneOnco Biopharmaceuticals (Inst); Scorpion Therapeutics (Inst); Zenshine (Inst)

Mei  Wei

Consulting or Advisory Role - bioTheranostics; Gilead Sciences; Gilead Sciences

Patents, Royalties, Other Intellectual Property - From Ambry Genetics for a software (I)

Matthew P.  Goetz

Consulting or Advisory Role - ARC Therapeutics (Inst); AstraZeneca (Inst); BioTheryX; Blueprint Medicines (Inst); Engage Health Media (Inst); Genzyme (Inst); Laekna Therapeutics; Lilly (Inst); Novartis (Inst); Rna Diagnostics (Inst); Seagen (Inst); Sermonix Pharmaceuticals (Inst); Tersera

Research Funding - AstraZeneca (Inst); Atossa Genetics (Inst); Lilly (Inst); Loxo (Inst); Pfizer (Inst); Sermonix Pharmaceuticals (Inst)

Patents, Royalties, Other Intellectual Property - Development of Human Tumor Xenografts from Women with Breast Cancer Treated with Neoadjuvant Chemotherapy (Inst); Methods and Materials for Assessing Chemotherapy Responsiveness and Treating Cancer; METHODS AND MATERIALS FOR USING BUTYRYLCHOLINESTERASES TO TREAT CANCER

Travel, Accommodations, Expenses - Lilly (Inst)

Laura  van 't Veer

Employment - Agendia

Stock and Other Ownership Interests  - Agendia; Exai Bio

Silver  Alkhafaji

No Relationships to Disclose

Hope S.  Rugo

Consulting or Advisory Role - Daiichi Sankyo; Eisai; Mylan; Napo Pharmaceuticals; Puma Biotechnology

Research Funding - Astellas Pharma (Inst); AstraZeneca (Inst); Daiichi Sankyo (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); Hoffmann-La Roche AG/Genentech, Inc (Inst); Lilly (Inst); Merck (Inst); Novartis (Inst); OBI Pharma (Inst); Pfizer (Inst); Stemline Therapeutics (Inst); Taiho Oncology (Inst); Veru (Inst)

Nan  Chen

Employment - GlaxoSmithKline (I)

Consulting or Advisory Role - AstraZeneca; GE Healthcare; Gilead Sciences; Guardant Health; Seagen; Stemline Therapeutics

W. Fraser Fraser  Symmans

Stock and Other Ownership Interests  - Delphi Diagnostics; Eiger BioPharmaceuticals; ISIS Pharmaceuticals

Consulting or Advisory Role - AstraZeneca; Merck

Patents, Royalties, Other Intellectual Property - Intellectual property; Intellectual Property (expired)

(OPTIONAL) Uncompensated Relationships - Delphi Diagnostics

Alexander D.  Borowsky

Leadership - Histolix

Stock and Other Ownership Interests  - Histolix

Consulting or Advisory Role - Tempus

Research Funding - Danaher (Inst)

Lamorna  Brown Swigart

No Relationships to Disclose

Natsuko  Onishi

Employment - Artera (I)

Stock and Other Ownership Interests  - Artera (I)

Douglas  Yee

Honoraria - Boehringer Ingelheim

Consulting or Advisory Role - Martell diagnostic

Research Funding - Boehringer Ingelheim

Nola  Hylton

Research Funding - Siemens Healthineers (Inst)

Laura  Esserman

Consulting or Advisory Role - Blue Cross Blue Shield Association

Research Funding - Moderna Therapeutics (Inst)

Travel, Accommodations, Expenses - Blue Cross Blue Shield Association

(OPTIONAL) Uncompensated Relationships - Quantum Leap Healthcare Collaborative