The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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CD4 effector T cell expansion to identify objective responses to the CD40 agonist mitazalimab in combination with modified FOLFIRINOX (mFFX) as first-line therapy for metastatic pancreatic ductal adenocarcinoma (mPDAC) in the OPTIMIZE-1 study.

Max Miller  Wattenberg

Consulting or Advisory Role - NanOlogy

Research Funding - HiberCell; Lilly

Karin  Enell Smith

Employment - Alligator Bioscience

Stock and Other Ownership Interests  - Alligator Bioscience

Patents, Royalties, Other Intellectual Property - Inventor "Novel Combination Therapies and Uses Thereof" Inventor "Anti-Cd40 Human Antibodies" Inventor "Novel Anti-Cd137 Antibodies and Uses Thereof"

Yago  Pico de Coaña

Employment - Alligator Bioscience

Stock and Other Ownership Interests  - Alligator Bioscience

Patents, Royalties, Other Intellectual Property - Inventor on patents assigned to Alligator Bioscience

Travel, Accommodations, Expenses - Alligator Bioscience

David  Gomez Jimenez

Employment - Alligator Bioscience

Stock and Other Ownership Interests  - Pfizer

Research Funding - Alligator Bioscience; Asgard therapeutics

Patents, Royalties, Other Intellectual Property - Title: Combination therapy PCT application number: PCT/EP2023/066889 (Inst)

Travel, Accommodations, Expenses - Alligator Bioscience

Sumeet Vijay  Ambarkhane

Employment - Alligator Bioscience; MorphoSys

Leadership - Alligator Bioscience

Stock and Other Ownership Interests  - Alligator Bioscience; MorphoSys

Patents, Royalties, Other Intellectual Property - Patent under review

Travel, Accommodations, Expenses - Alligator Bioscience; MorphoSys

Peter  Ellmark

Employment - Alligator Bioscience

Leadership - Alligator Bioscience

Stock and Other Ownership Interests  - Alligator Bioscience

Patents, Royalties, Other Intellectual Property - Inventor on patents assigned to Alligator Bioscience

Gregory Lawrence  Beatty

Stock and Other Ownership Interests  - Johnson & Johnson

Honoraria - Incyte; Janssen

Consulting or Advisory Role - Adicet Bio; Aduro Biotech; AstraZeneca; BiolineRx; Biomarin; Boehringer Ingelheim; Bristol-Myers Squibb; Cantargia AB; Cour Pharmaceuticals; Genmab; Hibercell; Hotspot Therapeutics; Incyte; Janssen; Legend Biotech; Merck; Molecular Partners; Monopteros Therapeutics; NanoGhost; Pancreatic Cancer Action Network; Seagen; Shattuck Labs; Verastem

Research Funding - Alligator Bioscience; Arcus Biosciences; Biothera; Bristol-Myers Squibb; Genmab; Gilead Sciences; Halozyme; HiberCell; Incyte; Janssen; Monopteros Therapeutics; Newlink Genetics; Verastem

Patents, Royalties, Other Intellectual Property - Inventor of intellectual property related to mesothelin CAR T cells that is licensed by the University of Pennsylvania to Novartis.; Inventor of intellectual property related to mesothelin CAR T cells that is licensed by the University of Pennsylvania to Tmnuity.