The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Safety and efficacy of first-in-class CXCR1/2 inhibitor SX-682 in combination with pembrolizumab (pem) in patients (pts) with metastatic melanoma (mMEL) with disease progression on anti–PD-1 therapy.
 
Sapna Pradyuman Patel
Honoraria - Emory University
Consulting or Advisory Role - Bristol Myers Squibb; Cardinal Health; Castle Biosciences; Delcath Systems; IDEAYA Biosciences; immatics; Immunocore; MSD; Novartis; OncoSec; Pfizer; Replimune; TriSalus Life Sciences
Speakers' Bureau - BMS GmbH & Co. KG; MSD
Research Funding - Bristol-Myers Squibb (Inst); Foghorn Therapeutics (Inst); IDEAYA Biosciences (Inst); InxMed (Inst); Lyvgen Biopharma (Inst); Novartis (Inst); Provectus (Inst); Seagen (Inst); Syntrix Biosystems (Inst); TriSalus Life Sciences (Inst)
Travel, Accommodations, Expenses - BMS GmbH & Co. KG; Castle Biosciences; InxMed; TriSalus Life Sciences
 
Anastasios Dimou
Honoraria - Intellisphere; Intellisphere (Inst); Intellisphere (Inst); Roche/Genentech
Consulting or Advisory Role - Anheart Therapeutics; ChromaCode; Guardant Health (Inst); TP Therapeutics (Inst)
Research Funding - Anheart Therapeutics (Inst); AstraZeneca (Inst); Guardant Health; Merck; Novartis (Inst); Sorrento Therapeutics (Inst); Syntrix Biosystems (Inst)
Travel, Accommodations, Expenses - Guardant Health
Other Relationship - Rising Tide Foundation (Inst)
 
Adrienne I. Victor
Honoraria - Rosenthal Research
Consulting or Advisory Role - Atheneum; Foundation Medicine; Genzyme
Research Funding - Bristol-Myers Squibb
Travel, Accommodations, Expenses - Foundation Medicine
 
Meghan Mooradian
Consulting or Advisory Role - AstraZeneca; Bristol Myers Squibb Foundation; Istari Oncology; Regeneron; Xilio Therapeutics
Other Relationship - Aptitude Health; Curio Science; Dava Oncology; OncLive/MJH Life Sciences
 
Elizabeth Iannotti Buchbinder
Employment - Alexion Pharmaceuticals (I); Takeda (I)
Consulting or Advisory Role - Instil Bio; Iovance Biotherapeutics; Merck; Nektar; Novartis; Pfizer; Sanofi; Werewolf Pharma; Xilio Therapeutics
Research Funding - Bristol-Myers Squibb; Checkmate Pharmaceuticals; Genentech/Roche; Lilly; Novartis
 
Leonel Fernando Hernandez-Aya
Consulting or Advisory Role - Bristol-Myers Squibb; Castle Biosciences; Massive Bio; Replimune; Replimune
Speakers' Bureau - Sanofi/Regeneron
Research Funding - Amgen (Inst); Bristol-Myers Squibb (Inst); Corvus Pharmaceuticals (Inst); Foghorn Therapeutics (Inst); immatics (Inst); immatics (Inst); Immunocore (Inst); MedImmune (Inst); Merck (Inst); Merck Serono (Inst); Moderna Therapeutics (Inst); Polynoma (Inst); Regeneron (Inst); Replimune (Inst); Roche/Genentech (Inst); Takeda (Inst)
Travel, Accommodations, Expenses - Bristol-Myers Squibb; Castle Biosciences; Sanofi/Regeneron
 
Peter A. Prieto
Employment - Iovance Biotherapeutics; University of Rochester
Stock and Other Ownership Interests - Castle Biosciences; Iovance Biotherapeutics
Honoraria - Castle Biosciences
Consulting or Advisory Role - Castle Biosciences
Speakers' Bureau - Castle Biosciences
Travel, Accommodations, Expenses - Castle Biosciences
 
Justine Vanessa Cohen
Consulting or Advisory Role - Bristol Myers Squibb; Incyte; Incyte; Regeneron; Replimune
 
Keith Flaherty
Leadership - Clovis Oncology; Kinnate Biopharma; Scorpion Therapeutics; Strata Oncology
Stock and Other Ownership Interests - Alterome Therapeutics; ALX Oncology; Apricity Health; Checkmate Pharmaceuticals; Clovis Oncology; FOGPharma; Kinnate Biopharma; Loxo; Monopteros Therapeutics; Nextech Invest; Oncoceutics; PIC Therapeutics; PreDICTA; Scorpion Therapeutics; Soley Therapeutics; Strata Oncology; Transcode Therapeutics; Tvardi Therapeutics; Vibliome Therapeutics; X4 Pharma; xCures
Consulting or Advisory Role - Debiopharm Group; Immagene; Karkinos Healthcare; Lilly; Novartis; OmRx Oncology; Oncoceutics; Quanta Therapeutics; Takeda; Tvardi Therapeutics
 
Stuart Kahn
Employment - Syntrix Biosystems
Consulting or Advisory Role - Syntrix Biosystems
 
Aaron Schuler
Employment - Syntrix Biosystems
Stock and Other Ownership Interests - Abbott Laboratories; Abbvie; AstraZeneca; Becton Dickinson; Boston Scientific; CVS Health; Intuitive Surgical; Johnson & Johnson/Janssen; Lilly; Medtronic; Merck; Thermo Fisher Scientific; United Health Group
Research Funding - Bristol-Myers Squibb; Syntrix Biosystems
 
Dean Maeda
Employment - Syntrix Biosystems
Patents, Royalties, Other Intellectual Property - I am a co-inventor on patents regarding intellectual property developed during my employment at Syntrix Pharmaceuticals. (Inst)
 
John Zebala
Employment - Syntrix Biosystems
Leadership - Syntrix Biosystems
Stock and Other Ownership Interests - Syntrix Biosystems
Research Funding - Syntrix Biosystems
Patents, Royalties, Other Intellectual Property - As an employee of Syntrix Pharmaceuticals, I am an inventor on numerous healthcare- and drug-related patents assigned to Syntrix Pharmaceuticals.
Travel, Accommodations, Expenses - Syntrix Biosystems