The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Characterization of the tumor immune microenvironment (TIME) and somatic landscape in gastrointestinal (GI) malignancies with MTAP deletions (del).

Jun  Gong

Honoraria - Agenus; Bayer; Eisai; Exelixis; Natera; Pfizer; Seagen; Taiho Pharmaceutical

Consulting or Advisory Role - Agenus; Bayer; Eisai; Exelixis; Natera; Pfizer; Seagan; Taiho Pharmaceutical

Kristen  Ciombor

Consulting or Advisory Role - Agenus; ALX Oncology; Bayer; Exelixis; Incyte; Merck; Pfizer; Taiho Oncology; Tempus

Research Funding - Abbvie (Inst); Amgen (Inst); Array BioPharma (Inst); Bayer (Inst); Boehringer Ingelheim (Inst); Boston Biomedical (Inst); Bristol-Myers Squibb (Inst); Bristol-Myers Squibb (Inst); Daiichi Sankyo (Inst); Genentech (Inst); Incyte (Inst); Incyte (Inst); MedImmune (Inst); Merck (Inst); Merck (Inst); Novartis (Inst); Nucana (Inst); Onyx (Inst); Pfizer (Inst); Pfizer/Calithera (Inst); Sanofi (Inst); Seagen (Inst); Syndax (Inst)

Travel, Accommodations, Expenses - Incyte; Tempus

Jennifer  Valerin

Consulting or Advisory Role - AstraZeneca; Myriad Genetics

Speakers' Bureau - AstraZeneca

Minxuan  Huang

Employment - Tempus AI, Inc.

Consulting or Advisory Role - ZS Associates

Edward  Williams

Employment - Tempus AI, Inc.

Stock and Other Ownership Interests  - Tempus AI, Inc.

Travel, Accommodations, Expenses - Tempus AI, Inc.

Melissa  Stoppler

Employment - Gilead Sciences (I); Roche/Genentech (I); Roche/Genentech (I); Tempus

Stock and Other Ownership Interests  - Exact Sciences; Gilead Sciences (I); Roche/Genentech (I); Tempus

Jacob  Mercer

Employment - Helsinn Therapeutics; QED Therapeutics; Tempus AI

Stock and Other Ownership Interests  - Bridgebio

Travel, Accommodations, Expenses - Helsinn Therapeutics; Tempus AI

John  Strickler

Stock and Other Ownership Interests  - Triumvira Immunologics, Inc

Consulting or Advisory Role - Abbvie; Astellas Pharma; AstraZeneca; Bayer; Beigene; Bristol Myers Squibb Foundation; Daiichi Sankyo/Astra Zeneca; GE Healthcare; GlaxoSmithKline; Ipsen; Jazz Pharmaceuticals; Johnson & Johnson/Janssen; Lilly; Merck; Natera (Inst); Pfizer; Regeneron; Roche/Genentech; Sanofi; Seagen; Taiho Oncology; Takeda

Research Funding - A*STAR (Inst); Abbvie (Inst); Amgen (Inst); Apollo Therapeutics; AstraZeneca/MedImmune (Inst); Bayer (Inst); BeiGene (Inst); Curegenix (Inst); Daiichi Sankyo/Lilly (Inst); Erasca, Inc (Inst); GlaxoSmithKline (Inst); Leap Therapeutics (Inst); Lilly (Inst); Novartis; Pfizer; Quanta Therapeutics (Inst); Revolution Medicines (Inst); Roche/Genentech (Inst)

Expert Testimony - Seagen