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Results from a phase 2 study of triplet blockade of the IL-27, PD-(L)1, and VEGF pathways with casdozokitug (casdozo, CHS-388) in combination with atezolizumab and bevacizumab in patients with unresectable, locally advanced or metastatic hepatocellular carcinoma (uHCC). |
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Consulting or Advisory Role - Abbvie; AstraZeneca; Coherus Biosciences; Eisai; Exelixis; Genentech; Jazz Pharmaceuticals; Merck; Sumitomo Pharma Oncology; TransThera Biosciences; TriSalus Life Sciences |
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Research Funding - AstraZeneca (Inst) |
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No Relationships to Disclose |
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Honoraria - Abbvie, BMS, Eisai, Gilead, Roche and Roche diagnostics |
Consulting or Advisory Role - Abbvie, BMS, Gilead, Roche and Roche diagnostics |
Speakers' Bureau - Abbvie, BMS, Eisai, Gilead, Roche and Roche diagnostics |
Research Funding - Abbvie, BMS, Gilead, Merck and Roche diagnostics. (Inst) |
Travel, Accommodations, Expenses - Abbott Laboratories |
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Consulting or Advisory Role - AstraZeneca; Bayer; BeiGene; BMS; Eisai; MSD Oncology; Ono Pharmaceutical; Roche; Sanofi; SERVIER |
Speakers' Bureau - AstraZeneca; Bayer; BMS; Dong-A ST; Eisai; Roche; Sanofi; SERVIER |
Research Funding - BeiGene; Boryung (Inst); Dong-A ST (Inst); Hanmi; inno-n; Roche (Inst) |
Travel, Accommodations, Expenses - Medivir (Inst) |
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Honoraria - Castle Biosciences (I) |
Consulting or Advisory Role - Arcus Biosciences (Inst); AstraZeneca (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); Elevation Oncology (Inst); EMD Serono (Inst); Ipsen (Inst); Jazz Pharmaceuticals (Inst); Pfizer (Inst); Seagen (Inst); Stemline Therapeutics (Inst); Takeda (Inst) |
Research Funding - 1200 Pharma (Inst); Abbvie (Inst); Actuate Therapeutics (Inst); Affini-T Therapeutics (Inst); Agenus (Inst); Arcus Biosciences (Inst); Astellas Pharma (Inst); BeiGene (Inst); BioNTech (Inst); Bristol-Myers Squibb (Inst); Codiak Biosciences (Inst); Compass Therapeutics (Inst); CytomX Therapeutics (Inst); CytomX Therapeutics (Inst); Eisai (Inst); Elevation Oncology (Inst); Elicio Therapeutics (Inst); Exelixis (Inst); Fate Therapeutics (Inst); Fog Pharmaceuticals (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); HiberCell (Inst); Immune-Onc Therapeutics (Inst); IMPAC Medical Systems (Inst); Jazz Pharmaceuticals (Inst); Kura Oncology (Inst); Leap Therapeutics (Inst); Neogene (Inst); Novartis (Inst); OncXerna Therapeutics (Inst); Panbela Therapeutics (Inst); Revolution Medicines (Inst); Roche (Inst); Seagen (Inst); SQZ Biotechnology (Inst); Surface Oncology (Inst); Tachyon Therapeutics (Inst); Takeda (Inst); Translational Genomics Research Institute (Inst); TransThera Sciences (Nanjing), Inc. (Inst); ZielBio (Inst) |
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Consulting or Advisory Role - AstraZeneca; Roche |
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Research Funding - ACCRU (Inst); AstraZeneca/MedImmune (Inst); Bristol-Myers Squibb (Inst); MedImmune (Inst) |
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Consulting or Advisory Role - AstraZeneca; GlaxoSmithKline; Incyte |
Speakers' Bureau - Incyte |
Research Funding - Amgen (Inst); Arcus Biosciences (Inst); Array BioPharma (Inst); Astellas Pharma (Inst); AstraZeneca/MedImmune (Inst); BeiGene (Inst); Bexion (Inst); Bristol-Myers Squibb (Inst); Celgene (Inst); EMD Serono (Inst); GlaxoSmithKline (Inst); Incyte (Inst); Merck Sharp & Dohme (Inst); Pfizer (Inst); seagen (Inst); Surface Oncology (Inst); Taiho Oncology (Inst); TransThera Biosciences (Inst); XBiotech (Inst) |
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Honoraria - AstraZeneca/MedImmune; Boostimmune; Boryung Pharmaceuticals; Bristol Myers Squibb; Daiichi Sankyo; MSD; Ono Pharmaceutical |
Consulting or Advisory Role - Mustbio |
Research Funding - Roche/Genentech/Foundation Medicine |
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No Relationships to Disclose |
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Stock and Other Ownership Interests - Coherus Biosciences |
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Employment - Coherus BioSciences |
Stock and Other Ownership Interests - Coherus BioSciences |
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Employment - Coherus BioSciences |
Stock and Other Ownership Interests - Coherus BioSciences |
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Honoraria - Bristol-Myers Squibb; Eisai; Merck Sharp & Dohme; Ono Pharmaceutical; Roche |
Consulting or Advisory Role - AstraZeneca; Bristol-Myers Squibb; Daiichi Sankyo; Merck Serono; Ono Pharmaceutical; Roche/Genentech |
Research Funding - AstraZeneca (Inst); BeiGene (Inst); Bristol-Myers Squibb (Inst); Eucure Biopharma (Inst); Ipsen (Inst); Johnson & Johnson (Inst); Merck Serono (Inst); MSD (Inst); NGM Biopharmaceuticals (Inst); Nucana (Inst); Ono Pharmaceutical (Inst); Roche/Genentech (Inst); Surface Oncology (Inst); Taiho Pharmaceutical (Inst) |
Travel, Accommodations, Expenses - Daiichi Sankyo; Roche |
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Consulting or Advisory Role - DAEHWA Pharmaceutical; HLB |