The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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A phase Ia/Ib study of talazoparib in combination with tazemetostat in metastatic castration-resistant prostate cancer (mCRPC).
 
Atish Choudhury
Employment - LeMaitre Vascular (I)
Honoraria - Aptitude Health; Color Genomics; DAVA Oncology; Great Debates and Updates; Lantheus Medical Imaging; Medscape; OncLive; Outcomes4Me; Pfizer; Physicans' Education Resource; Springer; Targeted Oncology; Wiley
Consulting or Advisory Role - Astellas Pharma; Bayer; Boundless Bio; Daiichi Sankyo; Janssen Oncology; Johnson & Johnson/Janssen; Pfizer; Pfizer; Sanofi/Aventis; Tolmar; Tolmar
Research Funding - Bayer (Inst); Lilly (Inst); Pfizer (Inst); Pfizer (Inst); Sumitomo Pharma Oncology (Inst)
Travel, Accommodations, Expenses - Astellas Pharma; Bayer
 
Caiwei Zhong
No Relationships to Disclose
 
Wanling Xie
Consulting or Advisory Role - Convergent Therapeutics; Prostate Cancer Clinical Trial Consortium
 
Alok Tewari
Stock and Other Ownership Interests - B.A.I. Biosciences; Inflammatix; Moderna Therapeutics; Teladoc
 
David Miyamoto
No Relationships to Disclose
 
Bose Kochupurakkal
Employment - Amgen (I)
Stock and Other Ownership Interests - Amgen (I)
Research Funding - Lilly
 
Luke Arsenault
No Relationships to Disclose
 
Claire Leisner
No Relationships to Disclose
 
Geoffrey Shapiro
Consulting or Advisory Role - Bicycle Therapeutics; Merck Serono; Xinthera
Research Funding - Bristol-Myers Squibb/Medarex (Inst); Lilly (Inst); Merck (Inst); Merck Serono (Inst); Pfizer (Inst); Tango Therapeutics (Inst)
Patents, Royalties, Other Intellectual Property - Patent # 10,934,593 B2 Compositions and methods for predicting response and resistance to CDK4/6 inhibition; Patent #: 9872874 Title: Dosage regimen for sapacitabine and seliciclib Issue Date: 1/23/2018
 
Alan D'Andrea
Stock and Other Ownership Interests - Cyteir; IMPAC Medical Systems; PrimeFour Therapeutics
Consulting or Advisory Role - Blacksmith/Lightstone Ventures; Bristol Myers Squibb; Covant Therapeutics/Roivant; cyteir; Deerfield Management Company; Faze Medicines; IMPAC Medical Systems; Pfizer; PrimeFour Therapeutics; Servier Bio-Innovation LLC; Tango Therapeutics; Zentalis Pharmaceuticals/Zeno Management
Research Funding - Bristol Myers Squibb; Merck Serono; Moderna Therapeutics; Tango Therapeutics
Travel, Accommodations, Expenses - IDEAYA Biosciences
 
Eliezer Van Allen
Stock and Other Ownership Interests - ervaxx; Genome Medical; Genomic Life; Manifold Bio; Microsoft; Monte Rosa Therapeutics; Riva Therapeutics; Serinus Bio; Syapse; Tango Therapeutics
Consulting or Advisory Role - ervaxx; Genome Medical; Genomic Life; Illumina; Janssen; Manifold Bio; Monte Rosa Therapeutics; Novartis; Riva Therapeutics; Serinus Bio; Syapse; Tango Therapeutics; Tracer Bio
Speakers' Bureau - Illumina; TD Cowen
Research Funding - Bristol-Myers Squibb; Nextpoint (Inst); Novartis; Sanofi (Inst)
Patents, Royalties, Other Intellectual Property - Patent on clinical interpretation algorithms using cancer molecular data (Inst); Patent on discovery of chromatin regulators as biomarkers of response to cancer immunotherapy (Inst); Patent on discovery of retained intron as source of cancer neoantigens (Inst)
Travel, Accommodations, Expenses - Roche/Genentech
 
Matthew Freedman
Stock and Other Ownership Interests - Precede Bio
Consulting or Advisory Role - Precede Bio
Patents, Royalties, Other Intellectual Property - A pending patent has been filed for detecting neuroendocrine prostate cancer using DNA methylation
 
Myles Brown
Stock and Other Ownership Interests - GV20 Therapeutics; Kronos Bio
Consulting or Advisory Role - FibroGen; GV20 Therapeutics; Kronos Bio; Novartis
Research Funding - Novartis
 
Mary-Ellen Taplin
Honoraria - Astellas Pharma; AstraZeneca; Blue Earth Diagnostics; Carden Jennings; Clovis Oncology; DAVA Pharmaceuticals; Flare Therapeutics; Interpublic GIS; Janssen-Ortho; MJH Healthcare Holdings, LLC; Novartis; Pfizer; Physicans' Education Resource; Propella Therapeutics; Research to Practice; UpToDate
Consulting or Advisory Role - Astellas Pharma; AstraZeneca; Blue Earth Diagnostics; Flare Therapeutics; Geode Therapeutics; Janssen-Ortho; Laekena; Novartis; Pfizer; Propella Therapeutics; UpToDate
Research Funding - Janssen-Ortho (Inst)
Travel, Accommodations, Expenses - Advanced Prostate Cancer Society; Prostate Cancer Foundation; South West Prostate Cancer Symposium
 
Himisha Beltran
Consulting or Advisory Role - AstraZeneca; Bayer; Daicchi Sankyo; Merck; Novartis; Pfizer; Sanofi
Research Funding - Bristol Myers Squibb Foundation (Inst); Circle Pharma (Inst); Daiichi Sankyo (Inst); Novartis (Inst)
Travel, Accommodations, Expenses - Janssen Oncology