The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Preliminary results from a first-in-human, phase I/II study of VLS-1488, an oral KIF18A inhibitor, in patients with advanced solid tumors.
 
Ecaterina Dumbrava
Consulting or Advisory Role - Bolt Biotherapeutics; Fate Therapeutics; Mersana; PMV Pharma; Summit Therapeutics
Speakers' Bureau - PMV Pharma
Research Funding - A2A Pharmaceuticals (Inst); Aileron Therapeutics (Inst); Amgen (Inst); Aprea Therapeutics (Inst); Astex Pharmaceuticals (Inst); AstraZeneca (Inst); Bayer (Inst); Bellicum Pharmaceuticals (Inst); Boehringer Ingelheim (Inst); Bolt Biotherapeutics (Inst); Compugen (Inst); Dragonfly Therapeutics (Inst); Fate Therapeutics (Inst); Genentech (Inst); Immunocore (Inst); Immunomedics/Gilead (Inst); Mereo BioPharma 5 (Inst); Mersana (Inst); ModeX Therapeutics (Inst); Pfizer (Inst); PMV Pharma (Inst); Poseida (Inst); Rain Therapeutics (Inst); Sanofi (Inst); Sotio (Inst); Triumvira Immunologics, Inc (Inst); Volastra Therapeutics (Inst)
Travel, Accommodations, Expenses - Boehringer Ingelheim; Rain Oncology; Triumvira Immunologics, Inc
 
Cara Mathews
Research Funding - AADI (Inst); Artios (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); avenge bio (Inst); Deciphera (Inst); Elucida Oncology (Inst); EMD Serono (Inst); Genmab (Inst); Immunogen (Inst); Laekna Therapeutics (Inst); Merck (Inst); Moderna Therapeutics (Inst); Pfizer (Inst); Regeneron (Inst); Repare Therapeutics (Inst); Roche/Genentech (Inst); Seagen (Inst); Tesaro/GSK (Inst); Volastra Therapeutics (Inst); Zentalis (Inst)
 
Bert O'Neil
Consulting or Advisory Role - Amgen
Speakers' Bureau - AstraZeneca
 
Paul Swiecicki
Honoraria - CDR-Life; Elevar Therapeutics; Elevar Therapeutics; Geovax Labs; Prelude Therapeutics; Remix Therapeutics; Seagen
Research Funding - Ascentage Pharma Group (Inst)
 
Stephanie Gaillard
Consulting or Advisory Role - AstraZeneca; Compugen; Verastem
Research Funding - AstraZeneca (Inst); Beigene (Inst); Blueprint Pharmaceutic (Inst); Compugen (Inst); Genentech/Roche (Inst); Immunogen (Inst); Pharma& (Inst); Tempest Therapeutics (Inst); Verastem (Inst); Volastra Therapeutics (Inst)
Patents, Royalties, Other Intellectual Property - United States Patent Nos 10,258,604 & 10,905,659, licensed by Duke University to Sermonix (Inst)
 
Alexander Starodub
No Relationships to Disclose
 
Patricia LoRusso
Honoraria - Five Prime Therapeutics
Consulting or Advisory Role - Abbvie; ABL Bio; Actuate Therapeutics; Agenus; Amgen; AstraZeneca; Atreca; BAKX Therapeutics; Boehringer Ingelheim; Compass Therapeutics; Cullinan Oncology; DAAN Biotherapeutics; EMD Serono; GlaxoSmithKline; I-Mab; ImCheck therapeutics; IQvia; Kineta; Kyowa Kirin International; Mekanistic Therapeutics; Mersana; Molecular Templates; Neurotrials Research; Pfizer; QED Therapeutics; Qualigen Therapeutics; Quanta Therapeutics; Relay Therapeutics; Roche/Genentech; Roivant; Scenic Biotech; Schrodinger; Seagen; Sotio; ST Cube; Stemline Therapeutics; Takeda; Zentalis
Research Funding - Genentech (Inst)
Travel, Accommodations, Expenses - Genentech
 
Marisa Moroney
No Relationships to Disclose
 
Jacob Thomas
Consulting or Advisory Role - Conjupro Biotherapeutics; Kura Oncology
 
Nehal Lakhani
Research Funding - Alexo Therapeutics (Inst); Alkermes (Inst); Alkermes/Mural Oncology (Inst); Alpine Immune Sciences (Inst); Alpine Immune Sciences (Inst); Apexian Pharmaceuticals (Inst); Arcus Ventures (Inst); Artios (Inst); Ascentage Pharma (Inst); Astellas Pharma (Inst); BeiGene (Inst); BioNTech SE (Inst); Biosplice (Inst); Celgene (Inst); Celgene (Inst); Constellation Pharmaceuticals (Inst); Coordination Therapeutics (Inst); CytomX Therapeutics (Inst); Epizyme (Inst); Forty Seven (Inst); Genmab (Inst); Genmab (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); Helsinn Therapeutics (Inst); Ikena Oncology (Inst); Ikena Oncology (Inst); Incyte (Inst); InhibRx (Inst); Innovent Biologics (Inst); Janssen (Inst); Jounce Therapeutics (Inst); KSQ Therapeutics (Inst); LAM Therapeutics (Inst); Lilly (Inst); Livzon (Inst); Loxo (Inst); Macrogenics (Inst); Merck (Inst); Mersana (Inst); Northern Biologics (Inst); Odonate Therapeutics (Inst); Pfizer (Inst); Quanta Therapeutics (Inst); Regeneron (Inst); Repare Therapeutics (Inst); Sapience Therapeutics (Inst); Sapience Therapeutics (Inst); Seagen (Inst); Servier (Inst); Shattuck Labs (Inst); SK Life Sciences (Inst); Symphogen (Inst); Tesaro (Inst); Tizona Therapeutics, Inc. (Inst)
 
Cindy Oh
Employment - Volastra Therapeutics
 
Celia Andreu
Employment - Volastra Therapeutics
Stock and Other Ownership Interests - Inspirna
Travel, Accommodations, Expenses - Volastra Therapeutics
 
Linda Lee
Employment - Volastra Therapeutics
 
Jacqueline Campbell
Employment - Volastra Therapeautics; Volatra
Stock and Other Ownership Interests - Replimune
Research Funding - Replimune; Volastra Therapeutics
Travel, Accommodations, Expenses - Replimune
 
Timothy Bowler
Employment - Dyno Therapeutics (I); Ivericbio (I); Pfizer; Regenxbio (I); Volastra Therapeutics
Stock and Other Ownership Interests - Regenxbio (I)
Travel, Accommodations, Expenses - Regeneron
 
Andrea Ozuna
Employment - Volastra Therapeutics
 
Jae Lee
Employment - Volastra Therapeutics
Stock and Other Ownership Interests - Volastra Therapeutics
 
Scott Drutman
Employment - Pfizer (I); Volastra Therapeutics
Leadership - Volastra Therapeutics
Stock and Other Ownership Interests - Pfizer (I); Volastra Therapeutics
 
Claire Friedman
Honoraria - GlaxoSmithKline; MJH Healthcare Holdings, LLC
Consulting or Advisory Role - AADi; Arch Oncology; Bristol Myers Squibb; Loxo/Lilly
Research Funding - AstraZeneca (Inst); Bristol-Myers Squibb (Inst); Daiichi Sankyo/UCB Japan (Inst); Genentech (Inst); Hotspot Therapeutics (Inst); Immunocore (Inst); Loxo/Lilly (Inst); Marengo Therapeutics (Inst); Merck (Inst); Seagen (Inst); Volastra Therapeutics (Inst)
Travel, Accommodations, Expenses - Puma Biotechnology
(OPTIONAL) Uncompensated Relationships - Genentech; Marengo Therapeutics; Merck